A5044609034- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Ginseng Biological Effects and Applications
- Autoimmune Bullous Skin Diseases
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Ear and Head Tumors
- Helicobacter pylori-related gastroenterology studies
- Chemokine receptors and signaling
- Cancer Risks and Factors
- Toxoplasma gondii Research Studies
- DNA and Nucleic Acid Chemistry
- Sphingolipid Metabolism and Signaling
- Neurofibromatosis and Schwannoma Cases
- Nanoplatforms for cancer theranostics
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Calcium signaling and nucleotide metabolism
- Platelet Disorders and Treatments
University of Oklahoma Health Sciences Center
2018-2024
Osaka University
2016-2022
Niigata University
2019
University at Buffalo, State University of New York
2019
Roswell Park Comprehensive Cancer Center
2019
Safingol, L- threo-dihydrosphingosine, induces cell death in human oral squamous carcinoma (SCC) cells through an endonuclease G (endoG) -mediated pathway. We herein determined whether safingol induced apoptosis and autophagy SCC cells. Safingol apoptotic a dose-dependent manner. In safingol-treated cells, microtubule-associated protein 1 light chain 3 (LC3)-I was changed to LC3-II the cytoplasmic expression of LC3, amount acidic vesicular organelles (AVOs) stained by acridine orange...
Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined. proportion viable after PF-543 treatment decreased time- dose-dependent manner, death occurred SphK1-expressing cells. Flow cytometry analysis revealed that induced both necrosis apoptosis. also granular accumulation LC3 conversion from LC3-I to LC3-II, which was blocked by autophagy inhibitors,...
Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses early-stage BC patients reveal emergence significantly rising when biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology post-biopsy tumors shows prolonged retention metastasis-permissive wound stroma dominated M2-like macrophages capable promoting cell...
Abstract Background Time to surgery (TTS) has been suggested have an association with mortality in early-stage breast cancer. Objective This study aims determine the between TTS and preoperative disease progression tumor size or nodal status among women diagnosed clinical T1N0M0 ductal Methods Women cancer who had breast-conserving as their first definitive treatment 2010 2016 ( n = 90,405) were analyzed using National Cancer Database. Separate multivariable logistic regression models for...
Neurofibromatosis type 1 (NF1) was first described in 1882 as a hamartomatous disorder of neural crest derivation. We present the imaging 65-year-old woman with NF1. Computed tomography revealed that there were three major findings presented: skeletal deformity, an area fat (probably related to mesodermal dysplasia), and benign neoplasm within masticator space. Moreover, masticatory muscles hypoplastic.
Chemotherapy is a mainstay of treatment for solid tumors. However, little known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast While CD45 level was significantly elevated DOX-treated wildtype mice, it remained unchanged tumors from null mice. Similarly, intravenous administration anti-E-selectin aptamer (ESTA) resulted...
Introduction: Needle biopsy is essential for definitive diagnosis of breast malignancy. Significant histologic changes due to tissue damage have been reported in solid tumors. This study investigated the association between time from needle and inflammation Methods: A total 73 stage I–II invasive cancer cases diagnosed by image-guided who had surgery as their first treatment were retrospectively analyzed. Time surgical excision ranged 8 252 days. Histological sections surgically resected...
Abstract Breast cancer is the most commonly diagnosed malignancy in U.S. and over two-thirds of invasive breast cases are early stage. However, 15-year survival rates for early-stage remain range 70-77%. Mounting evidence showed an increased risk disease progression mortality among patients whose surgery was delayed 60 days after diagnostic biopsy. Yet, mechanism(s) underlying rapidly due to delay diagnosis remains unknown. Our cohort analyses reveal emergence a significantly rising when...
Abstract Purpose We have previously reported that protracted Cyclooxygenase-2 (COX-2) activity in bone marrow-derived cells (BMDCs) infiltrating into biopsy wounds adjacent to the cavity of breast tumors mice promotes M2-shift macrophages and pro-metastatic changes cancer cells, effects which were suppressed by oral administration COX-2 inhibitors. Thus, local control wound may mitigate biopsy-induced changes. Methods A combinatorial delivery system—thermosensitive biodegradable poly(lactic...
Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by isolated cryptogenic thrombocytopenia due to a transient or persistent reduction in platelet count. Many patients with ITP have shown improved count after Helicobacter pylori eradication therapy. However, there been no studies regarding H. the oral cavity of ITP. Here, we describe patient whose samples exhibited pylori. A 64-year-old woman came our hospital chief complaints that required surgery, including tooth...
Abstract Background: Tumor-associated macrophages (TAMs) are considered to be one of the key players in tumor microenvironment, which regulates cancer invasion and metastases. TAMs can divided into two phenotypes with opposite functions. While M1 known exert anti-tumor activity by promoting pro-inflammatory effects immune responses such as intereukin-6 (IL-6) necrosis factor-α (TNF-α), M2 influence an anti-inflammatory response, wound healing, pro-tumorigenic properties. A bioactive lipid...