A5101399529- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Microbial Metabolism and Applications
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Metal complexes synthesis and properties
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- Photosynthetic Processes and Mechanisms
- Renal and related cancers
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Production and Characterization
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- Medicinal Plants and Neuroprotection
- Biochemical and Structural Characterization
- Cancer Research and Treatments
- Neuroscience and Neuropharmacology Research
Tzu Chi University
2019-2025
Buddhist Tzu Chi General Hospital
2019-2025
Guangdong Ocean University
2023-2024
Nantong University
2013-2024
Affiliated Hospital of Nantong University
2024
Yancheng Third People's Hospital
2024
Guilin Medical University
2024
Nanjing Normal University
2022-2024
Jilin Agricultural University
2023
National Engineering Research Center for Wheat
2023
Radiotherapy (RT) as one of the most powerful cancer treatment strategies has been greatly restricted by tumor hypoxia. A mounting effort devoted to develop oxygen delivery systems for boosting RT effect. Unluckily, those only supplied modest oxygen, which could not afford more than once and long-time RT. Herein, we describe development a glucose-regulated drug release platform, allowing long-term normoxic microenvironment repeated long time. The cycles resulted in sustained high Endostar...
Rapeseed (Brassica napus) is an important oilseed crop widely planted in the world, providing substantial edible oil and other nutrients for mankind. The composition of fatty acids affects processing quality vegetable oils, among which erucic acid (EA) potentially to cause health problems. Therefore, low (LEA) has always been a breeding trait B. napus. Fatty elongase 1 (FAE1) plays decisive role synthesis EA. There are two functional homologous copies FAE1 on A08 C03 chromosomes In this...
The present study utilized advanced psychometric methods (i.e., Rasch analysis and confirmatory factor [CFA]) to evaluate the structure of Multiple Intelligence Scale (MIS) its validity among Taiwanese older adults. A cross-sectional design using convenience sampling was conducted 200 community-dwelling participants aged 65 years or older. analyses showed that MIS had good unidimensionality. Among various CFA models testing structure, exploratory structural equation modelling performed best...
Background/Aims: MiR-30a-5p, a member of the microRNA-30 family (miR-30), is known to function as tumor suppressor in several different cancers. However, expression levels, biological function, and underlying mechanisms miR-30a-5p renal cell carcinoma (RCC) remain unclear. Glucose-regulated protein78 (GRP78) common cancer biomarker promotes growth survival cells. The GRP78 has been reported be modulated by miR-30a neurons. In this study, profile clear (ccRCC) its effect on ccRCC through...
Clear cell renal carcinoma (ccRCC) has been associated with one of the highest mortality rates among all cancers. Fatty acid binding proteins (FABPs) are 14‑15 kDa that highly abundant in cytosol most tissues. FABP5, a member FABP family, observed to promote tumor growth numerous cancer types. In order investigate function FABP5 ccRCC cells present study, RNA sequencing data from The Cancer Genome Atlas were analyzed determine expression levels patient samples. Survival and Cox regression...
The structure-activity relationship between digestion of walnut peptide (<3 kDa) and antioxidant activity were explored, the inhibitory effect DPP-IV on KGHLFPN (Lys-Gly-His-Leu-Phe-Pro-Asn) was selected. After simulated gastrointestinal digestion, peptides' capacities enhanced, tertiary structures weaker, secondary random coiled. C–H phylyl bonds broken macromolecular proteins hydrolyzed. Antioxidant a good inhibitor. And 4–8 h may be optimal time for oral absorption in vivo. Therefore,...
Our previous studies indicated that transcription factor Brn-4 is upregulated in the surgically denervated hippocampus vivo, promoting neuronal differentiation of hippocampal neural stem cells (NSCs) vitro. The molecules mediating upregulation remain unknown. In this study we examined levels insulin-like growth factor-1 (IGF-1) following denervation. Surgical denervation led to a significant increase IGF-1 expression vivo. We also report treatment on NSCs vitro marked acceleration and cell...
Purpose: Circular RNAs (circRNAs), are a large class of that from covalently closed continuous loop and have recently showed huge capabilities as gene regulators in mammals.Although Hsa_circ_0001451 has been investigated colorectal cancer, it remains unclear about the relationship between clear cell renal carcinoma (ccRCC).Our research aims to reveal function proliferation development ccRCC cells.Methods: The expression 52 pairs tissues paraneoplastic was detected by quantitative real-time...
Abstract Spinal cord injury (SCI) is associated with a dismal prognosis including severe voluntary motor and sensory deficits in the presence of current therapies, thus new efficient treatment strategies are desperately required. Along several advantages, such as easy accessibility, high-yield, potential enormous proliferation, menstrual blood-derived mesenchymal stem cells (MenSCs) have been proposed promising strategy regeneration medicine. In this study, MenSCs were transplanted into...
Focal and diffuse neuronal loss happened after traumatic brain injury (TBI). With little in the way of effective repair, recent interest has focused on endogenic neural progenitor cells (NPCs) as a potential method for regeneration. Whether regeneration cortex adult rat TBI remains to be determined. In this study, rats were divided into sham group group, model medium was induced by controlled cortical impact. Rats injected with BrdU at 1 7 days post-injury (dpi) allow identification...
Background: Circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, are involved in variety diseases, including several types cancers. We hypothesized that circRNAs the tumorigenesis and development clear cell renal carcinoma (ccRCC). Methods: To verify our hypothesis, we explored circRNA expression profiles 4 pairs ccRCC tissues their adjacent non-carcinoma via microarray analysis. Selected were further validated by qPCR. Moreover, hsa_circ_0005875 was selected for study...
The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands lncRNAs were identified, only few that regulate neurogenesis in are reported. present study aimed to perform microarray expression profiling identify long noncoding RNAs (lncRNAs) might participate hippocampal neurogenesis, investigate potential roles identified neurogenesis. In this study, suggested 74 activated 29 repressed (|log...
Background: This study investigated the biological function of gene MAN1C1 α-mannosidase in renal cell carcinoma. It has been reported that is probably a potential tumor suppressor Wilms. However, role human clear carcinoma (ccRCC) not reported. Methods: In this study, over-expression was used to transfect cancer lines 786-O and OS-RC-2 apoptosis underlying mechanisms which influence epithelial-mesenchymal transition. Results: down-regulated ccRCC related clinicopathological factors...
Abstract Neural stem cells (NSCs) possess self‐renewal and multilineage differentiation ability, thus are considered to be a potential source for cell replacement therapy of many nervous system diseases, such as neurodegenerative diseases. Valproate (VPA), member histone deacetylase inhibitor family, is an epigenetic regulator can promote NSCs differentiate into neurons, nevertheless, the underlying mechanisms process remain unclear. MicroRNAs (miRNAs) exert crucial part in...
Fucoxanthin and fatty acids are active substances that beneficial to the growth immunity of humans aquatic animals. However, relatively few species have been exploited for fucoxanthin in industry. At same time, due its low extract content, poor stability, high production cost, serious seasonal regional limitations, industry cannot normally meet greater demand international market. Therefore, this experiment seeks improve acid content C. weissflogii by adjusting nitrogen concentration culture...
Long noncoding RNAs (lncRNAs) have been identified as important factors in cancer biology and are deregulated many cancers. The present study aimed to determine the expression roles of lncRNA
Growth arrest-specific 5 (GAS5) is an anti-oncogene that has been extensively studied in tumors. However, research on GAS5 the context of nervous system disease rare at present. This study aimed to investigate role long non-coding RNA rat pheochromocytoma cells (PC12 cells). GAS5-overexpressing lentivirus was transfected into PC12 cells, and expression levels C-myc were detected by real-time PCR. Ratios S phase 5-ethynyl-2′-deoxyuridine. Immunohistochemical staining used detect...