A5101678956- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Renal Diseases and Glomerulopathies
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Pharmaceutical and Antibiotic Environmental Impacts
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- HER2/EGFR in Cancer Research
- Corporate Finance and Governance
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Extracellular vesicles in disease
- Vasculitis and related conditions
- Economic and Technological Innovation
- DNA and Nucleic Acid Chemistry
- Auditing, Earnings Management, Governance
- Ferroptosis and cancer prognosis
- Private Equity and Venture Capital
- Protease and Inhibitor Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
Wannan Medical College
2023
Zhejiang Wanli University
2023
Wuxi People's Hospital
2020-2023
Nantong University
2023
Institute of Philosophy
2023
Guangzhou University of Chinese Medicine
2023
University of South Florida
2022
Nanjing Medical University
2020-2022
Jiangsu Province Hospital
2022
Kaiping Central Hospital
2013
Abstract Osteosarcoma (OS) commonly metastasizes to the lung, yet underlying molecular mechanisms remain poorly understood. Exosomes play a crucial role in tumor migration, including OS lung migration. However, mechanism by which exosome-derived long non-coding RNAs (lncRNAs) contribute migration osteosarcoma remains unclear. This study presents newly discovered lncRNA, linc00881, derived from exosomes. Our shows that linc00881 promotes of cells and induces conversion normal fibroblasts into...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDNA cleavage by oxygen radicals produced in the absence of metal ions or lightKatsuyuki Nagai, Barbara J. Carter, Jinwen Xu, and Sidney M. HechtCite this: Am. Chem. Soc. 1991, 113, 13, 5099–5100Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ja00013a077https://doi.org/10.1021/ja00013a077research-articleACS PublicationsRequest reuse permissionsArticle...
In malignancies, cellular senescence is critical for carcinogenesis, development, and immunological regulation. Patients with acute myeloid leukemia (AML) have not investigated a reliable senescence-associated profile its significance in outcomes therapeutic response. Cellular senescence-related genes were acquired from the CellAge database, while AML data obtained GEO TCGA databases. The TCGA-AML group served as training set to construct prognostic risk score signature, GSE71014 was used...
Ferroptosis has emerged as a significant factor in the development of bronchopulmonary dysplasia (BPD). Nevertheless, our understanding potential involvement ferroptosis-related genes (FRGs) BPD remains incomplete. In this study, we leveraged Gene Expression Omnibus (GEO) database to investigate aspect. We identified 20 differentially expressed FRGs that are associated with BPD, shedding light on their role condition.LASSO along SVM-RFE algorithms found 12 genes: MEG3, ACSL1, DPP4, GALNT14,...
Long noncoding RNAs (lncRNAs) are critically involved in the occurrence and development of breast cancer (BC). In this study, we performed RNA sequencing, results revealed an increase expression level novel lncRNA ENST00000370438 tissues patients with BC. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) showed 23 pairs BC tissues. Next, determined effect on cell proliferation, that promotes proliferation The proteomic analysis a decrease DHCR24 cells transfected small...
Costimulatory molecules have been found to play significant roles in anti-tumor immune responses, and are deemed serve as promising targets for adjunctive cancer immunotherapies. However, the of costimulatory molecule-related genes (CMRGs) tumor microenvironment (TME) acute myeloid leukemia (AML) remain unclear. In this study, we described CMRG alterations genetic transcriptional fields AML samples chosen from two datasets. We next evaluated their expression identified distinct molecule...
BACKGROUND:Nephrotic syndrome (NS) is a common chronic kidney disease in children characterized by group of clinical symptoms such as massive proteinuria, hypoproteinemia, high edema, and hyperlipidemia. Despite the tremendous efforts already made, diagnosis for nephrotic still remains poor children. MATERIAL AND METHODS:The blood samples from 30 healthy with were collected. The expression H19 ADCK4 (which are genes recently identified to play key roles development syndrome) peripheral...
Fibroblast activation protein-alpha (FAP) is a transmembrane serine protease involving in tissue remodeling. Previous studies report that FAP highly expressed certain tumors and participated oncogenesis. However, there still lack of systematic in-depth analysis based on clinical big data. Here, we comprehensively map the expression profile, prognostic outcome, genetic alteration, immune infiltration across over 30 types human cancers through multiple datasets including TCGA, CPTAC,...
Media companies in various countries are transforming and upgrading to improve their competitiveness the digital economy. However, existing research only focuses on issue of how media transform while ignoring whether internal governance mechanisms such as compensation incentives can promote corporate value during transformation process. According principal-agent theory, we examined incentive effects executive system terms monetary compensation, equity perks a sample Chinese process...
Krüppel-like zinc-finger transcription factor 5 (KLF5) is a vital regulator of breast cancer (BC) onset and progression. The mechanism by which KLF5 regulates BC still not clearly known. In this study, bioinformatics analysis shows that BC-affected individuals with elevated expression levels have poor clinical outcomes. We further verify miR-145-5p regulated to promote cell apoptosis inhibit proliferation in via dual-luciferase reporter assay, western blot analysis, qRT-PCR, CCK-8 assay...