A5101708461- Parkinson's Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Nuclear Receptors and Signaling
- Sleep and related disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Cerebrovascular and genetic disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Diabetic Foot Ulcer Assessment and Management
- Folate and B Vitamins Research
- Autism Spectrum Disorder Research
- Adrenal Hormones and Disorders
- Immune Cell Function and Interaction
- Natural Compounds in Disease Treatment
- Mast cells and histamine
- Saffron Plant Research Studies
- Sodium Intake and Health
- Cardiac Fibrosis and Remodeling
- Cancer Immunotherapy and Biomarkers
- Frailty in Older Adults
Guangzhou University of Chinese Medicine
2025
Nanjing Medical University
2012-2024
Jiangsu Province Hospital
2009-2024
Wuhan University
2023
Hebei Medical University
2015-2023
Fourth Hospital of Hebei Medical University
2015-2023
Zhongnan Hospital of Wuhan University
2023
Gansu University of Traditional Chinese Medicine
2021
Michigan Medicine
2013
VA Ann Arbor Healthcare System
2013
Background The functional aspects of mast cell-microglia interactions are important in neuroinflammation. We have previously found that cell degranulation could directly induce microglia activation. However, the role LPS-induced activation, neuroinflammation and cognitive impairment has not been clarified. Methods studied brain cells interaction by site-directed injection cromolyn rat right hypothalamus using stereotaxic techniques. TFC Y maze were used to assess function. Mast stained...
Recent studies have revealed significant roles of neurotransmitters and gut microbiota along the gut–brain axis in Parkinson's disease (PD); however, potential mechanisms remain poorly understood. In current study, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced characteristic PD neurobehavior changes accompanied by increased α-synuclein, apoptotic protein Bim, cleaved caspase-3 decreased expression tyrosine hydroxylase (TH). Meanwhile, tryptophan (Trp) (Tyr) neurotransmitter...
Abstract Background Parkinson’s disease (PD) is a common central nervous system neurodegenerative disease. Neuroinflammation one of the significant neuropathological hallmarks. As traditional Chinese medicine, Safranal exerts anti-inflammatory effects in various diseases, however, whether it plays similar effect on PD still unclear. The study was to investigate and mechanism PD. Methods mouse model established by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP firstly. Next, degree muscle...
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism has been suggested to be associated with the risk of essential hypertension (EH), however, results remain inconclusive. To investigate this association, present meta‑analysis 27 studies including 5,418 cases and 4,997 controls was performed. pooled odds ratio (OR) its corresponding 95% confidence interval were calculated using random‑effects model. A significant association between MTHFR EH found under allelic (OR, 1.32;...
Leptomeningeal artery abnormalities in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) have not been extensively characterized. We quantified substructure diameter of leptomeningeal arteries CADASIL compared age-matched controls the very old; addition, we characterized intimal thickening using immunohistochemistry.Frontal temporal cortex 6 genetically proven brains (average age, 66 years), without symptoms cerebrovascular disease, old 89...
The goal of this study was to determine if vitamin D receptor (VDR) gene polymorphisms underlie susceptibility dyslipidemia in a Chinese Han population.Three tag single nucleotide (SNPs) (rs11574129, rs2228570, and rs739837) were genotyped using TaqMan assays VDR SNP associations with dyslipidemia. We 877 cases from normotensive, non-diabetes mellitus population 1822 non-dyslipidemia subjects stage I study. In follow-up II study, we included larger sample 3124 controls 1679 Finally, explored...
Aims/Introduction . The present study estimated the cost-effectiveness of bariatric surgery versus medication therapy for management recently diagnosed type 2 diabetes mellitus (T2DM) in obese patients from a Chinese health insurance payer perspective. Materials and Methods A Markov model was established to compare 40-year time costs quality-adjusted life-years (QALYs) between therapy. health-care group, proportion each group with remission diabetes, state transition probabilities were...
Background and Objective: Previous genetic studies in Parkinson's disease (PD) have provided conclusive evidence for association of genes with strong biological rationale PD. Recently several different populations found a between idiopathic PD the single-nucleotide polymorphism (SNP) rs2736990, located within an intron α-synuclein (SNCA) gene. In this study, we aimed to verify these findings explore characteristic subset Chinese Han patients. Materials Methods: A total 515 unrelated patients...
Immune checkpoint inhibitors (ICIs) have made significant breakthroughs in the treatment of a variety malignancies. As its use increases, unique immune-mediated toxicity profile ICls are becoming apparent. We report case immune-related endocrine adverse events (irAE) patient with hepatocellular carcinoma treated anti-programmed cell death protein 1 (PD-1) (tislelizumab). Although many irAEs been reported, few cases severe thyrotoxicosis described after immunotherapy literature. present...
Vitamin D deficiency can lead to high blood pressure. Polymorphisms in the vitamin hydroxylase gene have been associated with serum levels some Western countries. The aim of this study was investigate whether polymorphisms genes metabolic pathway contribute hypertension by affecting status a Han Chinese population. We selected four single nucleotide (SNPs; rs1993116 and rs10741657 CYP2R1; rs4809957 rs6068816 CYP24A1) for genotyping 525 control subjects 324 hypertensive patients, detected...
Restenosis is a major limiting factor for successful outcome in type 2 diabetes (T2D) patients undergoing percutaneous coronary intervention (PCI). The aim of this study to explore the role and regulatory mechanism FOS-like antigen 1 (FOSL1) restenosis T2D. A T2D with mouse model was established by combination high-fat diet streptozotocin injection wire-injury. High glucose (HG)-treated vascular smooth muscle cells (VSMCs) were used mimic vitro. results quantitative real time PCR western...
Abstract Background The high incidence of type 2 diabetes, the low rate compliance, and complex mechanism vascular disease caused by diabetes make its complications increase year year. Our study aimed to investigate clinical characteristics lower extremity diseases in evaluate long‐term efficacy intervention for these diseases. Methods From 2007 2014, 362 patients who underwent our hospital due were followed up 5 years their analyzed this retrospective study. Results Compared with those...