A5101607857- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Adolescent and Pediatric Healthcare
- Retinal Diseases and Treatments
- Olfactory and Sensory Function Studies
- Food Security and Health in Diverse Populations
- Advanced MRI Techniques and Applications
- Tea Polyphenols and Effects
- Nutrition, Health and Food Behavior
- Lysosomal Storage Disorders Research
- Antioxidant Activity and Oxidative Stress
- Gut microbiota and health
- Neurological Disorders and Treatments
- Eating Disorders and Behaviors
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Biochemical Analysis and Sensing Techniques
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
Xuzhou Medical College
2013-2025
Affiliated Hospital of Xuzhou Medical College
2013
Neuroinflammation plays a crucial part in the initial onset and progression of Alzheimer's disease (AD). NLRP3 inflammasome was demonstrated to get involved amyloid-β (Aβ)-induced neuroinflammation. However, mechanism Aβ-triggered activation remains poorly understood.
Studies have shown that rapid eye movement (REM) sleep behavior disorder (RBD) is a subtype of Parkinson's disease (PD) characterized by severe cognitive impairment and progression. However, reliable biological markers are lacking presently. Neurofilament light chain (NFL) glial fibrillary acidic protein (GFAP) been widely studied as biomarkers cognition impairment. This study aimed to find for the RBD PD investigating possible relationship between serum NFL, GFAP levels, subtype. A total...
ABSTRACT Objective Microglial activation plays a crucial role in neuroinflammation following ischemic stroke. This study was conducted to investigate the and potential mechanisms of MK5 within microglial cells inflammatory response stroke mice vivo vitro. Methods Microglia‐specific conditional knockout (MK5 cKO) their control f/f ) were subjected middle cerebral artery occlusion (MCAO). BV2 (a mouse cell line) transfected with small interfering RNA (siRNA) knock down levels subsequently...
Background Freezing of gait (FOG) is a common and disabling phenomenon in patients with Parkinson’s disease (PD), but effective treatment approach remains inconclusive. Dysfunctional emotional factors play key role FOG. Since primary motor cortex (M1) connects prefrontal areas via the frontal longitudinal system, where are responsible for regulation, we hypothesized M1 may be potential neuromodulation target FOG therapy. The purpose this study to explore whether high-frequency rTMS over...
Background: Previous studies have shown that tea consumption may a protective effect against neurodegenerative diseases. However, the exact causal relationship between and precursor stages of certain diseases, namely REM sleep behavior disorder (RBD), remains unclear. To evaluate association RBD, we employed Mendelian randomization study. Methods: We identified genetic instrumental variables are significantly associated with through genome-wide (GWAS) in European populations. Bidirectional...
Background and Objective: Previous genetic studies in Parkinson's disease (PD) have provided conclusive evidence for association of genes with strong biological rationale PD. Recently several different populations found a between idiopathic PD the single-nucleotide polymorphism (SNP) rs2736990, located within an intron α-synuclein (SNCA) gene. In this study, we aimed to verify these findings explore characteristic subset Chinese Han patients. Materials Methods: A total 515 unrelated patients...
Objectives The objective of this study is to investigate the indirect causalities between gut microbiota and sleep disorders. Methods In stage 1, we utilized 196 as exposure factor conducted a two-sample univariable Mendelian randomization (MR) analysis on five disorders: insomnia, excessive daytime sleepiness (EDS), sleep-wake rhythm disorders (SWRD), obstructive apnea (OSA), isolated REM behavior disorder (iRBD). 2, validated MR findings by comparing fecal abundance patients healthy...
To investigate whether glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), and 12 cytokines can serve as serum biomarkers of olfactory identification dysfunction in patients with Parkinson’s disease (PD). GFAP NFL levels were measured 75 PD 36 healthy controls (HCs). The assayed 41 PD. 16-item Sniffin’ Sticks test the Mini-Mental State Examination (MMSE) used to assess ability cognitive function, respectively. Linear regression models applied control for confounding...
Abstract Background Multiple system atrophy (MSA) and Parkinson’s disease (PD) have clinical overlapping symptoms, which makes differential diagnosis difficult. Our research aimed to distinguish MSA from PD using corneal confocal microscopy (CCM), a noninvasive objective test. Methods The study included 63 patients, 30 31 healthy controls (HC). When recruiting MSA, questionnaires were conducted on motor non-motor functions, such as autonomic cognitive functions. Participants underwent CCM...
Ischemic cerebrovascular disease may result in severe neurological deficits, and even death. Rho kinase is an important downstream substrate of protein. It involves multiple biological effects, including vascular smooth muscle Contraction, cell migration, inflammatory infiltration endothelial dysfunction. plays roles the processes occurrence, development expansion infarct volume ischemic disease. inhibitor can effectively relax spasm, reduce local response, protect function, increase blood...
Abstract Background: Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported to be involved in neuroinflammation Alzheimer's disease and traumatic brain injury. The present study was designed investigate the role of Dectin-1 its downstream target spleen tyrosine kinase (Syk) early injury after ischemic stroke using a focal cortex model. Methods: Adult male C57BL/6J mice were subjected cerebral ischemia model stroke. neurological score, adhesive removal test,...