A5017104358- Pain Mechanisms and Treatments
- Reproductive System and Pregnancy
- Epilepsy research and treatment
- Endometriosis Research and Treatment
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Ginseng Biological Effects and Applications
- Pain Management and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Neurobiology and Insect Physiology Research
- Pain Management and Placebo Effect
- Pregnancy-related medical research
- Natural product bioactivities and synthesis
- Gynecological conditions and treatments
- Neural dynamics and brain function
- Ovarian function and disorders
- Olfactory and Sensory Function Studies
- Pharmacological Effects and Toxicity Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced Drug Delivery Systems
- Maternal and fetal healthcare
Zhejiang Chinese Medical University
2022-2025
Taiyuan Maternity and Child Care Hospital
2024
Neuropathic pain involves complex cortical mechanisms, yet the role of medial secondary visual cortex (V2M) remains poorly understood. We hypothesized that glutamatergic neurons in V2M (V2MGlu) contribute to modulation and explored their functional involvement both normal neuropathic states. Here, we found V2MGlu could be activated by peripheral stimulation under conditions. Optical inhibition or activation unilateral respectively decreased increased bilateral nociceptive sensitivity, with...
Approximately 50% of cases with recurrent spontaneous abortion (RSA) have unexplained etiology. Aberrant expression transmembrane and ubiquitin-like domain containing 1 (TMUB1) is closely related to a series diseases, including RSA. However, the function underlying mechanism TMUB1 in occurrence RSA has not been described.
Phototherapy is an emerging non-pharmacological treatment for depression, circadian rhythm disruptions, and neurodegeneration, as well pain conditions including migraine fibromyalgia. However, the mechanism of phototherapy-induced antinociception not understood. Here, using fiber photometry recordings population-level neural activity combined with chemogenetics, we found that phototherapy elicits via regulation ventral lateral geniculate body (vLGN) located in visual system. Specifically,...
Objective: This study aimed to evaluate the therapeutic efficacy and safety of Dan'e Fukang soft extracts in moderate ovarian hyperstimulation syndrome (OHSS) for simultaneous treatment blood fluid, guided by traditional Chinese medicine principle "triple prevention". Methods: conducted a retrospective analysis clinical data from outpatients who underwent vitro fertilization (IVF)/intracytoplasmic sperm injection embryo transfer (ICSI-ET). A total 2245 cases were included divided into group...
Abstract Background Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, management pain is unsatisfactory. Here, we investigated analgesic effect and mechanism natural flavonoid naringenin (NAR) in collagen-induced (CIA) Methods NAR was injected (i.p.) once per day for 42 days after initial immunization, rats were sacrificed on 28th (the 21st final PID 21) 42nd (PID 35). The...
Widespread neuropathic pain usually affects a wide range of body areas and inflicts huge suffering on patients. However, little is known about how it happens effective therapeutic interventions are lacking. was induced by partial infraorbital nerve transection (p-IONX) evaluated measuring nociceptive thresholds. In vivo/vitro electrophysiology were used to evaluate neuronal activity. Virus tracing strategies, combined with optogenetics chemogenetics, clarify the role remodeling circuit in...
Early pregnancy loss (EPL) is a common adverse outcome with an incidence of approximately 10-30%. There are many factors that cause EPL, among which the lack proliferation and invasive properties trophoblast cells can lead to embryonic development. Therefore, in this study, molecular biology was investigated.Placental villous tissues from EPL patients were collected explore ELF1 PRR11 gene expression. The migration assessed by MTT, crystalline violet staining, traswell assays, respectively....
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and not well controlled by current therapeutics. Currently, how epileptic seizure affects cognitive performance still largely unclear, leading to situation that lacks precise treatment. Here, we used an activity-dependent labeling technique tag seizure-activated neurons the subiculum (SUB), region plays pivotal role cognition TLE. Combined with chemogenetics, Ca2+ fiber photometry approaches, sought reveal of these...