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Shimin Wang

ORCID: 0009-0000-8744-2810
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About
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A5040847989
Research Areas
  • Sperm and Testicular Function
  • Reproductive Biology and Fertility
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Renal and related cancers
  • Cancer Immunotherapy and Biomarkers
  • Pregnancy and preeclampsia studies
  • Reproductive System and Pregnancy
  • Reproductive biology and impacts on aquatic species
  • RNA Interference and Gene Delivery
  • Maternal and fetal healthcare
  • Immunotherapy and Immune Responses

Sun Yat-sen University
 2024-2025

Shanghai Ninth People's Hospital
 2024-2025

Shanghai Jiao Tong University
 2024-2025

Ruijin Hospital
 2025

 ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia
OPENALEX - Publications 
Shimin Wang Hongxian Wang Bicheng Jin Hongli Yan Qingliang Zheng and 1 more Dong Zhao

Non-obstructive azoospermia (NOA) belongs to male infertility due spermatogenesis failure. However, evidence for cell type-specific abnormalities of disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and assay transposase-accessible chromatin (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) NOA. HE staining confirmed the structural seminiferous tubules patients. identified 12 germ subtypes (spermatogonial stem cell-0 (SSC0),...

10.7554/elife.97958.2 preprint EN 2025-01-31
 PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development
OPENALEX - Publications 
Xiuping Zhang Shimin Wang Lixia Liang Fen Hu Xueluo Zhang and 3 more Xiangrong Cui Zhiping Zhang Xueqing Wu

10.1007/s10735-025-10364-z article EN Journal of Molecular Histology 2025-02-17
 PD-L1 siRNA incorporation into a cationic liposomal tumor mRNA vaccine enhances cytotoxic T cell activation and prevents immune evasion
OPENALEX - Publications 
Jingsheng Zhou Yuanyuan Li Xianghe Jiang Zhongyuan Xin Wenshang Liu and 12 more Xinyi Zhang Yonghua Zhai Zhuanzhuan Zhang Te Shi Minghao Xue Mengya Zhang Yan Wu Yanhui Chu Shimin Wang Xin Jin Weiping Zhu Jie Gao

10.1016/j.mtbio.2025.101603 article EN cc-by Materials Today Bio 2025-02-22
 ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia
OPENALEX - Publications 
Shimin Wang Hongxian Wang Bicheng Jin Hongli Yan Qingliang Zheng and 1 more Dong Zhao

Non-obstructive azoospermia (NOA) belongs to male infertility due spermatogenesis failure. However, evidence for cell type-specific abnormalities of disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and assay transposase-accessible chromatin (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) NOA. HE staining confirmed the structural seminiferous tubules patients. identified 12 germ subtypes (spermatogonial stem cell-0 (SSC0),...

10.7554/elife.97958.1 preprint EN 2024-06-17
 ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia
OPENALEX - Publications 
Shimin Wang Hongxian Wang Bicheng Jin Hongli Yan Qingliang Zheng and 1 more Dong Zhao

Abstract Non-obstructive azoospermia (NOA) belongs to male infertility due spermatogenesis failure. However, evidence for cell type-specific abnormalities of disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and assay transposase-accessible chromatin (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) NOA. HE staining confirmed the structural seminiferous tubules patients. identified 12 germ subtypes (spermatogonial stem...

10.1101/2024.04.09.588807 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-04-13
 ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia
OPENALEX - Publications 
Shimin Wang Hongxian Wang Bicheng Jin Hongli Yan Qingliang Zheng and 1 more Dong Zhao

Non-obstructive azoospermia (NOA) belongs to male infertility due spermatogenesis failure. However, evidence for cell type-specific abnormalities of disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and assay transposase-accessible chromatin (scATAC-seq) on testicular tissues from patients with obstructive azoospermia(OA) NOA. HE staining confirmed the structural seminiferous tubules patients. identified 12 germ subtypes (spermatogonial stem cell-0 (SSC0),...

10.7554/elife.97958 preprint EN 2024-06-17
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