A5100441371- Pulmonary Hypertension Research and Treatments
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Genomics, phytochemicals, and oxidative stress
- Cardiovascular and Diving-Related Complications
- dental development and anomalies
- Cardiac tumors and thrombi
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound and Hyperthermia Applications
- interferon and immune responses
- Gastroesophageal reflux and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer therapeutics and mechanisms
- Renal cell carcinoma treatment
- Peroxisome Proliferator-Activated Receptors
- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Xi’an Jiaotong-Liverpool University
2024
East China Normal University
2024
Johns Hopkins University
2024
Sun Yat-sen University
2023
Stomatology Hospital
2023
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
Hunan University of Traditional Chinese Medicine
2023
Shandong Tumor Hospital
2023
Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration is a major contributor to the elevated pulmonary resistance in patients with idiopathic arterial hypertension (IPAH).Here we report that increased hypoxia-inducible factor 2␣ (HIF-2␣) lung endothelial cells (LVECs) under normoxic conditions involved development of (PH) inducing endothelial-to-mesenchymal transition (EndMT), which subsequently results occlusive lesions.We observed...
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated resistance reported in patients with hypertension. We identified a differential role mammalian target rapamycin (mTOR) complex 1 and 2, two functionally distinct mTOR complexes, development hypertension (PH). Inhibition attenuated PH; however, inhibition 2 caused spontaneous PH, potentially up-regulation platelet-derived growth...
The ubiquitin-proteasome system is considered to be the key regulator of protein degradation. Bortezomib (BTZ) first proteasome inhibitor approved by US Food and Drug Administration for treatment relapsed multiple myeloma mantle cell lymphoma. Recently, BTZ was reported inhibit right ventricular hypertrophy vascular remodeling in hypoxia-exposed monocrotaline-injected rats. However, underlying mechanisms remain poorly understood. We previously confirmed that hypoxia-elevated basal...
AIM:To determine whether the positive status of human epidermal growth receptor 2 (HER2) can be regarded as an effective prognostic factor for patients with gastric cancer (GC) undergoing R0 resection. METHODS:A total 1562 GC treated by resection were recruited.HER2 was evaluated in surgically resected samples all
Purpose: Intestinal ischemia/reperfusion (I/R) injury is an unresolved clinical challenge due to its high prevalence, difficulty in diagnosis, and lack of clinically effective therapeutic agents. Ferroptosis a novel form cell-regulated death that has been shown play role various I/R models be immune-related. Further unraveling the molecular mechanisms associated with ferroptosis immunity intestinal may lead discovery potentially drugs. Methods: We obtained differentially expressed mRNAs...
Platelet‐derived growth factor is one of the major factors found in human and mammalian serum tissues. Abnormal activation platelet‐derived signaling pathway through receptors may contribute to development progression pulmonary vascular remodeling obliterative lesions patients with arterial hypertension. In this study, we examined expression receptor isoforms smooth muscle endothelial cells investigated whether secreted from cell or promotes proliferation. Our results showed that protein α β...
Transcription factor hypoxia-inducible 1α (Hif-1α) is known for its crucial role in promoting the pathogenesis of pulmonary hypertension (PH). Previous studies have indicated in-depth mechanisms that Hif-1α increases distal arterial (PA) pressure and vascular remodeling by triggering intracellular calcium homeostasis, especially store-operated entry (SOCE) process. In our recent research paper published Journal Molecular Medicine, we found transcription peroxisome proliferator-activated...
Although studies on the association between number of lymph nodes resected and prognosis in patients with pT2–4N0 stages gastric cancer have reported consistent results, there is no consensus optimal to be examined for pT1N0 stage cancer. The aim this study was evaluate long-term effect removed outcomes after R0 resection. From December 2009 2011, 227 undergoing resection at 4 Chinese centers were enrolled study. Patients assigned 2 groups according dissected (≤15 or > 15). Standard survival...
AIMTo investigate the safety and efficacy of S-1 plus oxaliplatin (SOX) as an adjuvant chemotherapy regimen in gastric cancer (GC) after D2 dissection. METHODS GC Patients who underwent gastrectomy fromSeptember 2009 to December 2011 four Chinese institutions were enrolled.Patients with stage ⅠB-ⅢC GC, received SOX treatment matched by propensity scores those surgery alone conducted capecitabine (XELOX) regimen.Disease-free survival (DFS) overall (OS) compared among groups.In addition,...
The number of elderly gastric cancer (GC) patients has been rapidly increasing worldwide, but inadequate understanding regarding GC led to the paucity appropriate treatment decisions. Our study evaluates clinicopathological characteristics and prognoses after R0 resection. Overall, 1877 consecutive who underwent gastrectomy at four centers were enrolled. We divided into three groups according age: young, middle, elderly. then analyzed prognoses. Compared middle-aged group, group had a higher...
Background: Accurate identification of vascular lumen region founded the base bubble detection and grading, which played a significant role in gas emboli for diagnosis decompression sickness. Objectives: To assist bubbles, it is crucial to develop an automatic algorithm that could identify areas ultrasound videos with interference presence. Methods: This article proposed automated recognition (VLRR) sketch accurate boundary between vessel tissues from dynamic 2D videos. It adopts area as...
The regeneration of the mammalian skeleton's craniofacial bones necessitates action intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically temporally to control differentiation osteogenic progenitors. Single-cell transcriptomics developing mouse calvarial suture recently identified a mesenchymal progenitor population with previously unappreciated tendon- or ligament-associated gene expression profile. Here, we developed Mohawk homeobox (MkxCG;...
The c-ETS-1 (ETS1) expression is high in clear cell renal carcinoma (ccRCC) tissues; however, how it impacts ccRCC currently unknown.
Myxoma is the most common tumor of heart that can cause embolism, obstruction, and cardiac failure, but rarely causes chylothorax. We herein report a case chylothorax caused by left atrial myxoma, which responded to diuretic therapy was subsequently cured resecting myxoma.This 63-year-old male with symptoms insufficiency who diagnosed myxoma. The patient also had massive pleural effusion on right side, as Sudan III staining content triglyceride. disappeared failure were relieved after...
The cyclin-dependent kinase subunit 2 (CKS2) is recognized to have a substantial impact on the pathogenesis and advancement of several malignant neoplasms. Nevertheless, its biological function prognostic significance in oral squamous cell carcinoma (OSCC) yet be thoroughly investigated. Our primary objective was clarify contribution CKS2 progression prognosis OSCC.We first conducted thorough examination online databases investigate expression CKS2, subsequently corroborated our discoveries...
This study aims to investigate the pathogenesis of chronic heart failure based on ferroptosis-mediated oxidative stress and predict targets Shenfu Injection in treating failure. A rat model was established by isoproterenol induction method. According random number table method, modeled rats were assigned into three groups: a group, ferrostatin-1(ferroptosis inhibitor) group. In addition, normal group designed. After 15 days intervention, cardiac mass index left ventricular determined....