A5029552856- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Connective Tissue Growth Factor Research
- Circular RNAs in diseases
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- PARP inhibition in cancer therapy
- Telomeres, Telomerase, and Senescence
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Pancreatic function and diabetes
- Genomics and Rare Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Machine Learning in Bioinformatics
- Hormonal Regulation and Hypertension
- Nuclear Structure and Function
- Nuclear Receptors and Signaling
University of Oulu
2014-2023
Guangzhou Medical University
2016-2020
University of Arizona
2018-2020
Oulu University Hospital
2019-2020
Guangzhou Women and Children Medical Center
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2013
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2012
Peking Union Medical College Hospital
2012
Chengdu University of Traditional Chinese Medicine
2010
Elucidation of the molecular mechanisms governing human adipose‐derived mesenchymal stem cells (hASCs) osteogenic differentiation is great importance for improving treatment bone‐related diseases. In this study, we examined role microRNA (miR)‐100 on osteogenesis hASCs. Overexpression miR‐100 inhibited hASCs in vitro, whereas downregulation enhanced process. Target prediction analysis and dual luciferase report assay confirmed that bone morphogenetic protein receptor type II (BMPR2) was a...
Myocardial infarction (MI)-induced cardiac fibrosis attenuates contractile function, and predisposes to arrhythmias sudden death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs virtually every fibrotic disorder the diseased human myocardium. Mice were subjected treatment with a CTGF monoclonal antibody (mAb) during infarct repair, post-MI left ventricular (LV) remodeling, or acute ischemia-reperfusion injury. mAb therapy repair improved survival reduced...
Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily secreted factors, are potent negative regulators muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim this study was investigate if activin 2B (ACVR2B) receptor ligands contribute IR injury. Mice were treated with soluble ACVR2B decoy (ACVR2B-Fc) subjected ischemia followed by reperfusion for 6 or 24 h. Systemic blockade ACVR2B-Fc protective against...
Pancreatic progenitor (PP) cells are tissue-committed cells, which can differentiate into all kinds of pancreatic cells. They potential candidates for regeneration tissue. However, it is unfeasible to acquire PP from tissues and expand them in vitro. Generation adipose tissue-derived mesenchymal stem (AD-MSCs) would provide an unlimited source Here we developed a 2-step stepwise protocol, induced AD-MSCs generate FOXA2- or SOX17-positive definitive endoderm (DE) (5 days) duodenal homeobox...
Traumatic brain injury (TBI) is a major cause of neurological disorder and death in civilian military populations. It comprises two components—direct from the traumatic impact secondary ensuing neural inflammatory responses. Blocking tumor necrosis factor-alpha (TNF-α), central regulator inflammation, has been shown to improve functional recovery after TBI. However, mechanisms underlying those therapeutic effects are still poorly understood. Here, we examined 3,6′-dithiothalidomide (dTT),...
Non-coding microRNAs (miRNAs) are powerful regulators of gene expression and critically involved in cardiovascular pathophysiology. The aim the current study was to identify miRNAs regulating cardiac fibrosis. Cardiac samples age-matched control subjects sudden death (SCD) victims with primary myocardial fibrosis (PMF) were subjected miRNA profiling. Old SCD PMF healthy aged human hearts showed increased miR-1468-3p. In vitro studies fibroblasts that augmenting miR-1468-3p levels induces...
BackgroundVascular endothelial zinc finger 1 (Vezf1) is a transcription factor previously shown to regulate vasculogenesis and angiogenesis. We aimed investigate the role of Vezf1 in postnatal heart.MethodsThe regulating cardiac growth contractile function was studied zebrafish primary cardiomyocytes.FindingsWe find that expression decreased diseased human myocardium mouse hearts. Our experimental data shows knockdown reduces results impaired ventricular response β-adrenergic stimuli....
Cardiac fibrosis stiffens the ventricular wall, predisposes to cardiac arrhythmias and contributes development of heart failure. In present study, our aim was identify novel miRNAs that regulate could serve as potential therapeutic targets for myocardial fibrosis.Analysis samples from sudden death victims with extensive primary cause identified dysregulation miR-185-5p. Analysis resident cells mice subjected experimental model showed induction miR-185-5p expression specifically in...
Platelet‐derived growth factor is one of the major factors found in human and mammalian serum tissues. Abnormal activation platelet‐derived signaling pathway through receptors may contribute to development progression pulmonary vascular remodeling obliterative lesions patients with arterial hypertension. In this study, we examined expression receptor isoforms smooth muscle endothelial cells investigated whether secreted from cell or promotes proliferation. Our results showed that protein α β...
Signaling through activin receptors regulates skeletal muscle mass and receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology the heart. In this study, we determined effect of systemic blockade ACVR2B on cardiac function experimental MI, defined its efficacy revert wasting ischemic heart failure (HF). Mice were treated with soluble decoy (ACVR2B-Fc) study post-MI remodeling later HF. Cardiac was echocardiography, myocardium analyzed...
To investigate the clinical and molecular features of congenital generalized lipodystrophy (CGL) in three Chinese patients with various typical manifestations.Data on symptoms, results laboratory analyses, previous treatments were collected by a retrospective review medical records. All coding regions adjacent exon-intron junction AGPAT2 BSCL2 genes amplified polymerase chain reaction sequenced.Generalized lipodystrophy, acanthosis nigricans, muscular hypertrophy, severe...
All coronary artery disease (CAD) patients do not benefit equally of secondary prevention. Individualized intensity drug therapy is currently implemented in guidelines for CAD and diabetes. Novel biomarkers are needed to identify patient subgroups potentially benefitting from individual therapy. This study aimed investigate endothelin-1 (ET-1) as a biomarker increased risk adverse events evaluate if medication could alleviate the risks with high ET-1.
Here we describe the second case of primary microcephaly caused by a novel homozygous splice-site variant at NCAPD2 gene. The proband was born with microcephaly, and developed intellectual disability. Whole exome sequencing identified canonical variant, c.3477+2T>C, Sanger showed that her sibling, symptomatic fetus, carried c.3477+2T>C while unaffected parents were heterozygous younger brother had wild-type alleles. To date, only one pathogenic gene has been reported. Our study two siblings...
Wnt11 regulates early cardiac development and left ventricular compaction in the heart, but it is not known how postnatal maturation response to stress adult heart. We studied cell proliferation/maturation adolescent deficient (Wnt11-/-) heart subjected mice with partial (Wnt11+/-) complete deficiency pressure overload. In addition, we primary cardiomyocytes recombinant Wnt proteins study their effect on cardiomyocyte growth. did affect proliferation or However, led enlarged phenotype that...
Background: Hyperactive cardiac sympathetic signaling characterizes chronic myocardial infarction. Although satellite glial cells (SGCs) regulate neuronal function, their role in mediating hyperactivity following injury remains poorly understood. Research Questions: The aim of the present study was to investigate impact on SGCs and SGC-neuronal communication stellate ganglion. Methods: Glial-specific reporter mice (7-9wks) with Cre-dependent tdTomato expression under fibrillary acidic...
Aim: Sorafenib (Nexavar) is a multitargeted tyrosine kinase inhibitor that used for treatment of hepatocellular carcinoma and renal cell carcinoma. Cancer with sorafenib has been reported to be associated cardiotoxic side effects such as hypertension, myocardial ischemia, thrombosis pulmonary embolism, whereas incidence LV dysfunction rare. Aim the current study was identify mechanism cardiotoxicity. Results: Healthy mice were treated (50 mg/kg/d) 4 weeks. Echocardiography analysis revealed...
Background: Accumulation of extracellular matrix disturbs the electrical conduction and stiffens myocardium, leading to higher risk for arrhythmias diastolic dysfunction. MicroRNAs (miRNAs) function in post-translational gene regulation, aberrant alteration miRNAs level has been implicated cardiac pathologies. Methods Results: RNA sequencing samples sudden death (SCD) victims with idiopathic myocardial fibrosis (IMF) differentially expressed identified miR-1468-3p. qPCR analysis validated...
Platelet‐derived growth factor (PDGF), is one of the major factors found in mammalian serum, which plays an important role cell growth. It has been previously demonstrated that abnormal activation PDGF signaling pathway can contribute to aberrant pulmonary vascular remodeling and hypertension via active receptors. The overall goal this study was examine expression PDGFR isoforms both artery smooth muscle cells (PASMC) endothelial (PAEC) identify whether produced PASMC or PAEC promotes...