A5012584989- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Effects of Environmental Stressors on Livestock
- Herpesvirus Infections and Treatments
- Noise Effects and Management
- Graphene and Nanomaterials Applications
- Allergic Rhinitis and Sensitization
- Facial Trauma and Fracture Management
- Vestibular and auditory disorders
- Thyroid Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Traumatic Ocular and Foreign Body Injuries
- Cancer-related molecular mechanisms research
- Microbial infections and disease research
- Cardiovascular and Diving-Related Complications
- Hydrogen's biological and therapeutic effects
- Pediatric health and respiratory diseases
- Obstructive Sleep Apnea Research
- Carbon and Quantum Dots Applications
- Metabolomics and Mass Spectrometry Studies
- Medical Research and Treatments
- Neurological Disease Mechanisms and Treatments
- Energy and Environment Impacts
- Healthcare Systems and Public Health
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2023
Sun Yat-sen University
2016-2023
State Key Laboratory of Respiratory Disease
2016-2019
Guangzhou Medical University
2016-2019
First Affiliated Hospital of Guangzhou Medical University
2017-2019
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic lung characterized by abnormal inflammation, persistent and progressive function decline. The anti-inflammatory actions of tanshinone IIA, which the most important active component from Chinese herbal medicine Danshen, have been well studied. However, it remains unknown whether sodium IIA sulfonate (STS) protects against development COPD. Here we found that STS inhalation (5 mg/kg, 30 min per session, twice day) significantly...
Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and promotes oxidative stress inflammation in chronic obstructive pulmonary disease (COPD). The present study investigated whether sodium tanshinone IIA sulfonate (STS), a water-soluble derivative IIA, can mediate its effect through inhibiting HIF-1α-induced cigarette smoke (CS)-induced COPD mice. Here, we found that STS improved function, ameliorated emphysema decreased the infiltration inflammatory cells...
Animal model of cigarette smoke (CS) -induced chronic obstructive pulmonary disease (COPD) is the primary testing methodology for drug therapies and studies on pathogenic mechanisms disease. However, researchers have rarely run simultaneous or side-by-side tests whole-body nose-only CS exposure in building their mouse models COPD. We compared evaluated these two different methods exposure, plus airway Lipopolysaccharides (LPS) inhalation, our COPD model. Compared with control group, exposed...
Introduction Although anaplastic thyroid carcinoma (ATC) is rare, it one of the most aggressive human cancers. The optimal multimodal therapy policy ATC still debated, and a standardized treatment strategy remains to be established. This study aimed evaluate management aspect prognosis ATC. Materials Methods data were analyzed retrospectively for 50 patients with clinical characters, factors influencing survival. Survival analysis was performed by Kaplan-Merier method log-rank test,...
One of the main clinical treatments for advanced nasopharyngeal carcinoma is chemotherapy, but systemic administration can cause serious adverse reactions. New type nanomaterial which actively targeting, imaging, and treating at same time to enhance effect meanwhile monitoring intracellular drug release process level single cancer cell was urgently needed. GE11, an EGFR antagonist peptide, used target has positive expression on its nucleus. GE11-modified graphene quantum dots (GQDs@GE11)...
Chronic obstructive pulmonary disease (COPD) is a chronic lung with limited treatment options. Hydrogen (H2) has been shown to be anti-oxidative and anti-inflammatory. This study aimed evaluate the beneficial effects of H2 inhalation on COPD development in mice.A mouse model was established male C57BL mice by cigarette smoke (CS) exposure. The intervention administered atomisation inhalation. Lung functions were assessed using Buxco function measurement system. inflammatory cells counted...
To investigate the clinical efficacy of tiotropium in children with asthma.
Head and neck squamous cell carcinoma (HNSCC) is a highly heterotopic malignant tumor. Alternative splicing (AS) RNA modification have been reported to be involved in tumorigenesis. Therefore, we constructed modification-associated AS (RMA-AS) signature model predict the prognosis of HNSCC. events RNA-modified gene expression information were downloaded from TCGA-HNSCC database. Univariate Cox regression analysis was employed for analyzing prognosis-related events. RMA-AS obtained by...
Many scales are designed to screen for obstructive sleep apnoea-hypopnoea syndrome (OSAHS); however, there is a lack of an efficiently and easily diagnostic tool, especially Chinese. Therefore, we conduct cross-sectional study in China develop validate efficient simple clinical model help patients at risk OSAHS.This based on 782 high-risk (aged >18 years) admitted the Sleep Medicine department Sixth Affiliated Hospital, Sun Yat-sen University from 2015 2021. Totally 34 potential predictors...
Objective To observe the optimal timing of operation and therapeutic effect endoscopic optic nerve decompression for traumatic neuropathy （TON）. Methods The clinical records 90 consecutive patients with TON （93 eyes） after head and/or maxillofacial trauma from April 1998 to March 2007 were reviewed analyzed. All either unresponsive or intolerant medication before they underwent intranasal decompression. time interval between injury ranged one day 97 days （median 5.5 days）. Among 93 eyes,...
Objective To observe the effect of compound anisodine postauricular injection combined with conventional scheme in treatment sudden deafness. Methods 100 patients deafness who underwent initial our department from April 2015 to January 2017 were observed. The control group received routine treatment, and study on basis once per day, 14 days as a course treatment. curative compared between two groups. Results 79 competed whole cure rate was 44.7% (17/38), effective 57.9% (22/38);...
Tonsillitis is the inflammation of tonsils due to infection, many patients ultimately have undergo tonsillectomy. In order improve accuracy diagnosis and even create a new treatment for tonsillitis, we constructed prokaryotic expression single-chain antibody fragment library against Streptococcus pneumoniae with immunoglobulin heavy chain variable region (VH), κ light (Vκ), λ (Vλ) genes by using human tonsil tissue. Plasmid DNA sequencing showed that antibodies were complete correctly. The...
Objective To explore the characteristics of deafness gene carrying preliminary. Methods 69 subjects were enrolled, including patients, health who had deaf family members, and did not have from March 1 to 31 in 2018. 159 genes locus sequencing 22 performed all subjects, hearing status questionnaires recorded. Results The pathogenic detected 69 GJB2, MT-RNR1, SLC26A4. The positive rate patients was 33.3% (16/48), members 53.8% (7/13), 0% (0/8). There statistically significant...