A5101427260- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Ferroptosis and cancer prognosis
- Fungal Biology and Applications
- Circular RNAs in diseases
- Microbial Natural Products and Biosynthesis
- Renal and related cancers
- Plant Pathogens and Fungal Diseases
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Genomics and Rare Diseases
- CAR-T cell therapy research
- Acne and Rosacea Treatments and Effects
- Histone Deacetylase Inhibitors Research
- Autonomous Vehicle Technology and Safety
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
Nanjing University
2025
Shandong First Medical University
2022-2025
Academy of Medical Sciences
2024-2025
Nanjing General Hospital of Nanjing Military Command
2025
First People's Hospital of Chongqing
2025
Guangdong Academy of Sciences
2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
GenomiCare (China)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2022-2024
A NIR fluorescent probe for monitoring senescence was developed with SA-β-gal and HClO as targets under high lysosomal pH conditions. The precise tracking of cellular/ in vivo achieved a ratiometric sensing pattern.
Abstract Ovarian cancer is the most lethal malignancy among gynecologic cancers, and primary secondary chemotherapy resistance one of important reasons for poor prognosis ovarian patients. However, specifics to in remain unclear. Herein, we find that expression level cellular retinoic acid binding protein 2 (CRABP2) up-regulated drug-resistant tissues cell lines, levels CRABP2 epithelial are closely related tumor clinical stage patients’ prognosis, suggesting plays an role progression...
In this report, we demonstrated that inorganic arsenic (iAs) induces generation of the cancer stem-like cells (CSCs) through Nrf2-dependent HIF1α activation, and subsequent metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis in epithelial cells.Methods: Genome-wide ChIP-seq analysis was performed investigate global binding Nrf2 and/or on genome treated with iAs.Both untargeted metabolomics UDP-13 C-glucose flux were applied determine iAs-induced CSCs.The role...
Since the approval of chimeric antigen receptor (CAR) T cell therapy targeting CD19 by FDA, CAR-T has received increasing attention as a new method for tumors. Although good effect against hematological malignancies, it been less effective solid In present study, we selected mesothelin (MSLN/MESO) target cells because is highly expressed tumors but only at low levels normal tissues. We engineered third generation MSLN-CAR comprising single-chain variable fragment (scFv) MSLN (MSLN-scFv), CD8...
Identification of mechanisms that program early effector T cells to either terminal (T eff ) or memory m has important implications for protective immunity against infections and cancers. Here, we show the cytosolic transcription factor aryl hydrocarbon receptor (AhR) is used by fate. Upon antigen engagement, AhR rapidly up-regulated via reactive oxygen species signaling in CD8 + cells, which does not affect response, but required formation. Mechanistically, activated up-regulate HIF-1α...
Abstract The removal of hydrogen peroxide (H 2 O ) by antioxidants has been proven to be beneficial patients with vitiligo. Aspirin (acetylsalicylic acid, ASA antioxidant activity and great preventive therapeutical effect in many oxidative stress‐relevant diseases. Whether can protect human melanocytes against stress needs further studied. Here, we investigated the potential protective mechanisms H ‐induced injury melanocytes. Human were pre‐treated different concentrations , followed...
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated resistance reported in patients with hypertension. We identified a differential role mammalian target rapamycin (mTOR) complex 1 and 2, two functionally distinct mTOR complexes, development hypertension (PH). Inhibition attenuated PH; however, inhibition 2 caused spontaneous PH, potentially up-regulation platelet-derived growth...
The tumor-suppressive role of p53, a transcription factor that regulates the expression many genes, has been linked to cell cycle arrest, apoptosis, and senescence. noncanonical function or pathogenic p53 more recently implicated in pulmonary vascular disease. We previously reported rapid nuclear accumulation hypoxia-inducible (HIF)-1α arterial smooth muscle cells (PASMCs) upregulates transient receptor potential channels enhances Ca2+ entry increase cytosolic concentration ([Ca2+]cyt)....
The diffuse large B-cell lymphoma (DLBCL) has the highest incidence of all lymphomas worldwide. To investigate functions lymphocyte activation gene 3 (LAG-3) and programmed cell death 1 (PD-1) in tissues peripheral blood patients with DLBCL, expression LAG-3 PD-1 genes DLBCL-TCGA were analyzed.
Background: Multiple myeloma (MM), a malignant proliferative disease of plasma cells, poses serious threat to the health middle-aged and elderly populations. To better understand global trends in MM provide scientific basis for targeted prevention treatment strategies, this study aims use burden (GBD) 2021 data an updated assessment prevalence, incidence, mortality disability-adjusted life years (DALYs) at global, regional national levels from 1990 2021. The analysis is further stratified by...
Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes protein posttranslational modifications. However, the role of palmitoylation oocyte has not been investigated. In present study, new association between redox oocytes was found. We found that level palmitoyl-protein thioesterase 1 (PPT1), depalmitoylation enzyme, maternally aged mice follicular fluid (age >35 years) patients with decreased ovarian reserve...
Objective Epilepsy, a prevalent neurological disorder, has multifaceted etiologies. Next-generation sequencing (NGS) emerged as robust diagnostic tool for this condition. This study aims to evaluate the detection efficiencies of different exome-based techniques. Methods Exome-based epilepsy panel tests, clinical exome (CES), and whole (WES) were conducted on 259 pediatric patients diagnosed with epilepsy. Single-nucleotide variants (SNVs) copy number (CNVs) interpreted based each patient’s...
To evaluate the clinical efficacy of fractional laser treatment combined with bipolar radiofrequency for improving atrophic facial acne scars. The data patients scars treated in Dermatology Department People's Hospital Chongqing Liangping District from October 2022 to 2023 were retrospectively analyzed. divided into two groups based on methods: single intervention group (Group A, n=25) and B, n=25). Group A received therapy only, a cycle 4 weeks cycles per course. B combination treatment,...
Abstract This review investigates Rhizoctonia species, highlighting their taxonomy, genetic diversity, and pathogenic mechanisms that pose significant challenges to agriculture horticulture. spp. are complex pathogens capable of infecting a wide range hosts through sophisticated infection strategies developing resistance commonly used fungicides, threatening global food security. Key findings reveal the necessity integrated disease management combine cultural practices, biological control,...
Purpose This study evaluates the efficacy of rapid clinical exome sequencing (CES) and mitochondrial DNA (mtDNA) for diagnosing genetic disorders in critically ill pediatric patients. Methods A multi-centre investigation was conducted, enrolling patients suspected having from March 2019 to December 2020. Peripheral blood samples their parents were analyzed using CES (proband-parent) mtDNA (proband-mother) based on Next-Generation Sequencing (NGS) technology. Results The included 44 (24...
Arsenic produces liver disease through the oxidative stress. While lutein can alleviate cytotoxic and injury, nuclear factor erythroid 2-related 2 (Nrf2) pathway plays a critical role in defending species. However, mechanisms by which protects against effect of arsenic are not known. Therefore, this study aims to investigate involved action using mice model hepatotoxicity was induced arsenic. We found that treatment with could reverse changes morphological indexes result significant...
Background and Purpose Sustained pulmonary vasoconstriction excessive vascular remodelling are two major causes of elevated resistance in patients with arterial hypertension. The purpose this study was to investigate whether chloroquine induced relaxation the artery (PA) attenuates hypoxia‐induced hypertension (HPH). Experimental Approach Isometric tension measured rat PA rings pre‐constricted phenylephrine or high K + solution. pressure mouse isolated, perfused ventilated lungs. Fura‐2...
Ovarian cancer (OC) is one of the most lethal solid tumors with poor prognosis. In 2017, two chimeric antigen receptor-T (CAR-T) cell drugs were approved by U.S. Food and Drug Administration (FDA), continuously optimized CAR-T cells therapy might be novel hope for OC patient. EpCAM are known to over-expressed in could targeted cells. However, feasibility using EpCAM-CAR-T treat still needs verified. We engineered 3rd-generation EpCAM-CAR containing a single-chain variable fragment (scFv)...
Root rot is a major disease that causes decline of alfalfa production, and Fusarium pathogen associated with root rot. In this study, 13 isolates were obtained from in Gansu Province, the production region China. The characterized by molecular genotyping ( ITS , TEF 1-α RPB2 fragments) identified as six species, which included F. acuminatum incarnatum oxysporum proliferatum redolens F . solani We found their morphology varied significantly at both macro- micro-levels, even for those same...
Hepatocyte nuclear factor 4 alpha (HNF4A) is a transcriptional which plays an important role in the development of liver, kidney, and intestines. Nevertheless, its cervical cancer underlying mechanism remain unknown. In this study, both immunohistochemistry western blotting revealed that expression HNF4A was downregulated cancer. Xenograft assays suggested HN4A could inhibit tumorigenic potential vivo. Functional studies illustrated also inhibited proliferation viability cells vitro....
// Qianling Liu 1 , Jie Jin Jianming Ying 2 Yun Cui Mengkui Sun Lian Zhang Yu Fan Ben Xu Qian Department of Urology, Peking University First Hospital and Institute National Research Center for Genitourinary Oncology, Beijing 100034, China Pathology, Cancer Hospital, Union Medical College (PUMC), Chinese Academy Sciences, 100021, Correspondence to: Zhang, e-mail: zhangqian@bjmu.edu.cn zhangqianbmu@vip.sina.com Keywords: ASC/TMS1, tumor suppressor, DNA methylation, renal cell carcinoma,...