A5056411271- Muscle Physiology and Disorders
- Tendon Structure and Treatment
- Single-cell and spatial transcriptomics
- Cellular Mechanics and Interactions
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Cardiovascular Effects of Exercise
- Genetic Neurodegenerative Diseases
- Risk Perception and Management
- Connective tissue disorders research
- Zoonotic diseases and public health
- dental development and anomalies
- CRISPR and Genetic Engineering
- Chronic Lymphocytic Leukemia Research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Laser Applications in Dentistry and Medicine
- Neurogenetic and Muscular Disorders Research
- Immune cells in cancer
- Immune responses and vaccinations
- Vaccine Coverage and Hesitancy
- Immunodeficiency and Autoimmune Disorders
- Genetics and Physical Performance
- Osteoarthritis Treatment and Mechanisms
Johns Hopkins University
2014-2024
Carnegie Institution for Science
2014-2024
Carnegie Observatories
2024
Department of Embryology
2014-2024
Broad Institute
2020-2021
Louisiana State University Health Sciences Center New Orleans
2010
ABSTRACT The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2 (ACE2) associated proteases, transmembrane protease serine (TMPRSS2) Cathepsin L (CTSL), were previously identified as mediators of SARS-CoV2 cellular entry. Here, we assess cell type-specific RNA expression ACE2 , TMPRSS2 CTSL through integrated...
Abstract The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is known about the host tissue immune cellular responses associated with COVID-19 infection, symptoms, lethality. To address this, we collected tissues from 11 organs during clinical autopsy of 17 individuals who succumbed COVID-19, a bank approximately 420 specimens. We generated...
Summary We report the generation of five mouse strains with tamoxifen‐inducible Cre ( Cre‐ER T 2 ; CE ) gene cassette knocked into endogenous loci Pax3 , Myod1 Myog Myf6 and Myl1 collectively as a resource for skeletal muscle research community. characterized these using reporter mice, R26R L acZ during embryogenesis show that they direct tightly controlled expression within expected cell lineage determined by each myogenic gene. also examined few selected adult groups expression. None new...
Tendon is a vital musculoskeletal tissue that prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components remain poorly understood. Collagen VI and biglycan are two molecules localize pericellularly within critical regulators of properties. While evidence suggests collagen interact the matrix, relationship its impact on function remains unknown. We sought elucidate potential coordinate roles by defining properties in knockout models...
Skeletal muscles connect bones and tendons for locomotion posture. Understanding the regenerative processes of muscle, bone tendon is importance to basic research clinical applications. Despite their interconnections, distinct transcription factors have been reported orchestrate each tissue’s developmental processes. Here we show that Scx expression not detectable in adult muscle stem cells (also known as satellite cells, SCs) during quiescence. begins activated SCs continues throughout...
For non-optically clear mammalian tissues, it is now possible to use multi-photon microscopy penetrate deep into the tissue and obtain detailed single cell images in a live animal,
Skeletal muscles connect bones and tendons for locomotion posture. Understanding the regenerative processes of muscle, bone tendon is importance to basic research clinical applications. Despite their interconnections, distinct transcription factors have been reported orchestrate each tissue’s developmental processes. Here we show that Scx expression not detectable in adult muscle stem cells (also known as satellite cells, SCs) during quiescence. begins activated SCs continues throughout...
Skeletal muscles connect bones and tendons for locomotion posture. Understanding the regenerative processes of muscle, bone tendon is importance to basic research clinical applications. Despite their interconnections, distinct transcription factors have been reported orchestrate each tissue’s developmental processes. Here we show that Scx expression not detectable in adult muscle stem cells (also known as satellite cells, SCs) during quiescence. begins activated SCs continues throughout...
The regeneration of the mammalian skeleton's craniofacial bones necessitates action intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically temporally to control differentiation osteogenic progenitors. Single-cell transcriptomics developing mouse calvarial suture recently identified a mesenchymal progenitor population with previously unappreciated tendon- or ligament-associated gene expression profile. Here, we developed Mohawk homeobox (MkxCG;...
Abstract Skeletal muscles connect bones and tendons for locomotion posture. Understanding the regenerative processes of muscle, bone tendon is importance to basic research clinical applications. Despite their interconnections, distinct transcription factors have been reported orchestrate each tissue’s developmental processes. Here we show that Scx expression not detectable in adult muscle stem cells (also known as satellite cells, SCs) during quiescence. begins activated SCs continues...
It is confusing: many common colds are caused by coronaviruses, but not all coronaviruses cause colds. Some, like SARS-CoV-2, the coronavirus responsible for COVID-19, can serious health complications and death. To reduce risk of public innocently (and understandably) conflating COVID-19 with mild sicknesses associated a cold, one job would need to be "make familiar strange familiar." But wait, that work anthropology. I argue what missing from discussions straight answer simple question...