A5084995275- Carbohydrate Chemistry and Synthesis
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Polysaccharides and Plant Cell Walls
- Studies on Chitinases and Chitosanases
- Lysosomal Storage Disorders Research
- Polyamine Metabolism and Applications
- Extracellular vesicles in disease
- Enzyme Production and Characterization
- Adenosine and Purinergic Signaling
- Sulfur-Based Synthesis Techniques
- Microbial Metabolites in Food Biotechnology
Xiangya Hospital Central South University
2022
Central South University
2022
Wayne State University
2018-2022
Hunan Cancer Hospital
2022
The preparation and characterization of a series di-, tri-, tetrasaccharide analogues β-(1→3)-glucans is described in which each pyranoside ring replaced by 5-thiopyranosyl glycosidic oxygen thioether. These oligomeric 1,5-dithio-d-glucopyranose derivatives were shown to inhibit the staining human neutrophils mouse macrophages fluorescent anti-CR3 anti-Dectin-1 antibodies, respectively. compounds also demonstrated stimulate phagocytosis pinocytosis indicative binding carbohydrate domains...
Abstract During a synthesis of 3,5‐dithio‐glucofuranose, we discovered two interesting intramolecular displacement reactions involving thiolate sulfur on the one hand and thiirane other. Both generated 3,6‐thiaanhydro structures. We solved problem by using 5‐ S ,6‐ O ‐isopropylidene protecting group accomplished 3,5‐dithio‐glucofuranose in 9 % overall yield.
Immunotherapy has partly achieved striking outcomes in the clinic for specific tumors. However, responses are still limited tumors that have restricted filtration and decreased activity of cytotoxic T cells due to tumor stroma physical obstacles immune-suppressive factors. Here we report an effective synergistic strategy therapy via integrating photothermal blockade metabolic immune pathway adenosine based on a novel black phosphorus nanobomb. By rational conjugation A2A receptor inhibitor...