A5088542239- Wound Healing and Treatments
- Hair Growth and Disorders
- Hippo pathway signaling and YAP/TAZ
- RNA regulation and disease
- Silk-based biomaterials and applications
- Nuclear Receptors and Signaling
- Mathematical Dynamics and Fractals
- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Apelin-related biomedical research
- Dermatologic Treatments and Research
- Quantum chaos and dynamical systems
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Mechanical Engineering and Vibrations Research
- Systemic Sclerosis and Related Diseases
- Point processes and geometric inequalities
- Immunotherapy and Immune Responses
- Genital Health and Disease
- Pomegranate: compositions and health benefits
- Surface Treatment and Residual Stress
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Scientific Research and Discoveries
SASTRA University
2019-2024
Institute for Stem Cell Biology and Regenerative Medicine
2018-2024
University of Oxford
2023
Preservation of a small population cancer stem cells (CSCs) within heterogeneous carcinoma serves as paradigm to understand how select in tissue maintain their undifferentiated status. In both embryogenesis and cancer, Snail has been correlated with stemness, but the molecular underpinning this phenomenon remains largely ill-defined. models cutaneous squamous cell (cSCC), we discovered non-epithelial-mesenchymal transition function for transcription factor maintaining stemness epidermal...
Wound healing in the skin is a complex physiological process that product of cell state transition from homeostasis to repair. Mechanical cues are increasingly being recognized as important regulators cellular reprogramming, but mechanism by which it translated changes gene expression and ultimately behavior remains largely mystery. To probe molecular underpinnings this phenomenon further, we used down-regulation caspase-8 biomarker entering wound program. We found wound-induced release...
The wound-healing process is a paradigm of the directed migration various pools stem cells from their niche to site injury where they replenish damaged cells. Two decades have elapsed since observation that wounding activates multipotent hair follicle infiltrate epidermis, but cues coax these out remain unknown. Here, we report Caspase-1, protein classically known as an integral component cytosolic inflammasome, secreted upon and has non-canonical role in extracellular milieu. Through its...
<title>Abstract</title> Tyrosine hydroxylase (TH) is a key enzyme that catalyzes dopamine synthesis in various regions of the brain. Expression TH diversely regulated Olfactory bulb (OB) and Midbrain (MB). Different sets transcription factors (TFs) control expression these two most them are exclusive to either OB or MB. Zinc finger factor cerebellum 3 (ZIC3) known regulate forebrain development. However, role ZIC3 regulation its underlying mechanism remains unknown. While loss function...
ABSTRACT The wound-healing process is a paradigm of the directed migration various pools stem cells from their niche to site injury where they replenish damaged cells. Two decades have elapsed since observation that wounding activates multipotent hair follicle infiltrate epidermis, but cues coax these out remains unknown. Using an excisional wound and genetic mouse models healing, we discovered Caspase-1, protein classically known as integral component cytosolic inflammasome, secreted has...
ABSTRACT Wound healing in the skin is a complex physiological process that product of cell state transition from homeostasis to repair. Mechanical cues are increasingly being recognized as important regulators cellular reprogramming, but mechanism by which it translated changes gene expression and ultimately behavior remains largely mystery. To probe molecular underpinnings this phenomenon further, we used downregulation caspase-8 biomarker entering wound-healing program. We found...
We prove convergence of Hausdorff measure level sets smooth Gaussian fields when the levels converge. Given two coupled stationary $f_1, f_2$ , we estimate difference in expectation, terms $C^2$-fluctuations field $F=f_1-f_2$. The main idea proof is to represent volume as an integral mean curvature using divergence theorem. This approach different from Kac-Rice type formula tool analysis.
Abstract Androgenic alopecia (AGA) is a pathological condition characterized by the progressive decrease of scalp hair follicle density. Completely bald areas AGA still retain stem cells but progenitor are drastically decreased in number. However, it unknown when begin to diminish number during progression AGA. Despite prevalence 58% Indian male population, no study date has and cell populations patients this ethnic group. We observed that partially area retains expressing CD34 Sox9 they not...
ABSTRACT Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes onset fibrosis we observed that this phenomenon recapitulated in Snail transgenic mouse model SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction leakage. Our investigation into mechanism phenotype revealed Angiopoietin-like...
Abstract Dopaminergic (DA) neurons in the Olfactory bulb (OB) are involved odor detection and discrimination. Transcription factor (TF) regulatory network responsible for their fate specification remains poorly understood spatial regulation of DA elusive. In this study, mice exposed to stimulant exhibited specific upregulation Zinc finger transcription Cerebellum (ZIC) 3 along with Tyrosine Hydroxylase (TH). Stringent co-expression analysis showed ZIC3 TH dual positive OB. Genetic...