A5073930412- Systemic Sclerosis and Related Diseases
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Dermatologic Treatments and Research
- Mast cells and histamine
- Cellular Mechanics and Interactions
- Wnt/β-catenin signaling in development and cancer
- Hair Growth and Disorders
- Lipid Membrane Structure and Behavior
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Calcium signaling and nucleotide metabolism
- SARS-CoV-2 and COVID-19 Research
- Kruppel-like factors research
- Angiogenesis and VEGF in Cancer
- Genital Health and Disease
- Redox biology and oxidative stress
- Mesenchymal stem cell research
- Connective tissue disorders research
- Lymphatic System and Diseases
- Axon Guidance and Neuronal Signaling
- Antimicrobial Peptides and Activities
- Pomegranate: compositions and health benefits
- Wound Healing and Treatments
Institute for Stem Cell Biology and Regenerative Medicine
2013-2024
National Centre for Biological Sciences
2021-2022
Abstract Fibrosis is a pervasive disease in which the excessive deposition of extracellular matrix (ECM) compromises tissue function. Although underlying mechanisms are mostly unknown, stiffness increasingly appreciated as contributor to fibrosis rather than merely manifestation disease. Here we show that loss Fibulin-5, an elastic fibre component, not only decreases stiffness, but also diminishes inflammatory response and abrogates fibrotic phenotype mouse model cutaneous fibrosis....
Preservation of a small population cancer stem cells (CSCs) within heterogeneous carcinoma serves as paradigm to understand how select in tissue maintain their undifferentiated status. In both embryogenesis and cancer, Snail has been correlated with stemness, but the molecular underpinning this phenomenon remains largely ill-defined. models cutaneous squamous cell (cSCC), we discovered non-epithelial-mesenchymal transition function for transcription factor maintaining stemness epidermal...
Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading poor prognosis. Unraveling etiology of chronic, multifactorial such as systemic has been aided by various animal models recapitulate certain aspects human pathology. We found transcription factor SNAI1 overexpressed epidermis patients with sclerosis, transgenic mouse recapitulating this expression pattern sufficient induce many clinical features disease. Using model discovery...
The wound-healing process is a paradigm of the directed migration various pools stem cells from their niche to site injury where they replenish damaged cells. Two decades have elapsed since observation that wounding activates multipotent hair follicle infiltrate epidermis, but cues coax these out remain unknown. Here, we report Caspase-1, protein classically known as an integral component cytosolic inflammasome, secreted upon and has non-canonical role in extracellular milieu. Through its...
ABSTRACT Fibrosis is a result of chronically activated fibroblasts leading to the overproduction extracellular matrix (ECM), causing tissue hardening and loss organ function. Systemic sclerosis (SSc) fibrotic skin disease marked by inflammation, autoimmunity vasculopathy along with progressive fibrosis internal organs. A major bottleneck in understanding etiology SSc has been lack holistic animal model that can mimic human disease. We found transcription factor Snail overexpressed epidermis...
The continual emergence of SARS-CoV-2 variants threatens to compromise the effectiveness worldwide vaccination programs, and highlights need for complementary strategies a sustainable containment plan. An effective approach is mobilize body's own antimicrobial peptides (AMPs), combat infection propagation. We have found that human cathelicidin (LL37), an AMP at epithelial barriers as well in various bodily fluids, has capacity neutralise multiple strains SARS-CoV-2. Biophysical computational...
Fibrosis results from excessive extracellular matrix (ECM) deposition, causing tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, ECM production. However, it remains unclear if the same fibroblast performs all of processes that fall under umbrella term "activation". Due heterogeneity in connective tissues, subpopulations with specific functions may operate distinct regulatory controls. Using a...
ABSTRACT The wound-healing process is a paradigm of the directed migration various pools stem cells from their niche to site injury where they replenish damaged cells. Two decades have elapsed since observation that wounding activates multipotent hair follicle infiltrate epidermis, but cues coax these out remains unknown. Using an excisional wound and genetic mouse models healing, we discovered Caspase-1, protein classically known as integral component cytosolic inflammasome, secreted has...
ABSTRACT Fibrosis is the result of excessive deposition extracellular matrix (ECM) proteins leading to tissue hardening and loss organ function. A central player driving fibrosis activated fibroblast, which exhibits enhanced migration, proliferation, contraction, ECM production. However, this raises an interesting puzzle whether same fibroblast performs all processes that fall under umbrella term “activation”. Given heterogeneity fibroblasts in connective tissues, there are subpopulations...
Summary Intratumoral heterogeneity poses a major challenge in designing effective anti-cancer strategies. Accumulating evidence suggests that this arises from cancer stem cells (CSCs) also drives tumor aggressiveness and drug resistance. The stemness of CSCs are preserved by an ill-defined combination intrinsic external factors is particularly intriguing since they exist within sea similar at various degrees differentiation. In models cutaneous squamous cell carcinoma (cSCC), we discovered...
ABSTRACT Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes onset fibrosis we observed that this phenomenon recapitulated in Snail transgenic mouse model SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction leakage. Our investigation into mechanism phenotype revealed Angiopoietin-like...
Abstract The continual emergence of new SARS-CoV-2 variants threatens the effectiveness worldwide vaccination programs and highlights need for complementary strategies a sustainable containment plan. A promising approach is to mobilize body⍰s own antimicrobial peptides (AMPs), combat infection propagation. We have found that human cathelicidin (LL37), an AMP at epithelial barriers as well in various bodily fluids, has capacity neutralise multiple strains SARS-CoV-2. Biophysical computational...