A5106125929- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Systemic Sclerosis and Related Diseases
- Skin and Cellular Biology Research
- Cancer and Skin Lesions
- Eosinophilic Disorders and Syndromes
- Platelet Disorders and Treatments
- Oral Health Pathology and Treatment
- Mast cells and histamine
- RNA regulation and disease
- Cardiac tumors and thrombi
- Hair Growth and Disorders
- Dermatological and Skeletal Disorders
- Dermatologic Treatments and Research
- Fungal Infections and Studies
- Nail Diseases and Treatments
- melanin and skin pigmentation
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Connective tissue disorders research
- Allergic Rhinitis and Sensitization
Christian Medical College & Hospital
2014-2024
Vellore Institute of Technology University
2023
Christian Medical College
2015-2020
University Dermatology
2015
Vehicle Technologies Office
2008
The Royal Free Hospital
2007
University College London
2007
Sankara Nethralaya
2007
Jamia Millia Islamia
2007
Abstract Fibrosis is a pervasive disease in which the excessive deposition of extracellular matrix (ECM) compromises tissue function. Although underlying mechanisms are mostly unknown, stiffness increasingly appreciated as contributor to fibrosis rather than merely manifestation disease. Here we show that loss Fibulin-5, an elastic fibre component, not only decreases stiffness, but also diminishes inflammatory response and abrogates fibrotic phenotype mouse model cutaneous fibrosis....
Fibrosis is a prevalent pathological condition arising from the chronic activation of fibroblasts. This results extensive intercellular crosstalk mediated by both soluble factors and direct cell-cell connections. Prominent among these are interactions fibroblasts with immune cells, in which fibroblast-mast cell connection, although acknowledged, relatively unexplored. We have used Tg mouse model skin fibrosis, based on expression transcription factor Snail epidermis, to probe mechanisms...
Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading poor prognosis. Unraveling etiology of chronic, multifactorial such as systemic has been aided by various animal models recapitulate certain aspects human pathology. We found transcription factor SNAI1 overexpressed epidermis patients with sclerosis, transgenic mouse recapitulating this expression pattern sufficient induce many clinical features disease. Using model discovery...
Abstract: The aim of this study was to describe the clinical profile children with congenital pigmentary anomalies along Blaschko lines and associated manifestations in central nervous system. Twenty‐six aged 12 years or less (14 boys girls), hypopigmentation hyperpigmentation system were included during period June 2001 December 2003. Detailed physical, cutaneous, systemic examinations carried out. Relevant investigations histopathology, karyotyping, electroencephalogram, computerized...
Nested PCRs for human immunodeficiency virus type 1 (HIV-1) and HIV-2 were compared with immunoblot test results. Twelve of 13 immunoblot-positive samples positive by PCR. There five INNO-LIA (Innogenetics, Zwijnaarde, Belgium) and/or HIVBLOT 2.2 (Genelabs, Singapore) that tested dual infection. HIV-1 PCR was in all samples, while two RIBA (Chiron Corporation, San Diego, Calif.) three samples. Thus the prevalence is accurately estimated use immunoblotting, but -2 infection may be overestimated.
The chronic use of immunosuppressants in renal transplant recipients (RTRs) predisposes them to a variety skin manifestations. Studies on lesions RTRs from India have been limited.To study the prevalence and clinical spectrum diseases RTR patients attending Nephrology clinic tertiary care hospital South India.Between October 2002 June 2003, 365 were evaluated for lesions, including 280 examined after (group A) 85 once before then monthly period 6 months B).A total 1163 346 (94.7%) aesthetic...
Key Clinical Message Ichthyosis prematurity syndrome (IPS) is reported mainly from Scandinavia where most of the cases are homozygous or compound heterozygous for nonsense mutation c.504C>A (p.Cys168*) in exon3 indicating a common ancestor this mutation. The occurrence IPS an Indian patient suggests that it more widespread than previously reported.
Epidermolytic acanthoma (EA) is a rare benign tumor that shows epidermolytic hyperkeratosis (EH) on histopathology. It can occur in solitary or disseminated form. This condition needs to be distinguished from other hereditary acquired conditions may show EH. We diagnosed an unusual case of EA the vulva presenting linear pattern 50-year-old lady based clinical features and typical histopathological findings stress importance considering differential diagnosis verrucous lesions genitalia.
Abstract: Keratosis lichenoides chronica (KLC) is an acquired keratinization disorder that rare in childhood. We report a case of sporadic pediatric‐onset KLC with seborrheic dermatitis‐like lesions on the forehead, papules retiform pattern axillae and mons pubis, eye oral mucosal involvement,with additional features premature canities transient photosensitive eruption.
The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is a newly described tool used to assess the activity of damage caused by cutaneous lupus erythematosus (CLE). There paucity data on CLASI from Indian subcontinent. We sought determine applicability in specific lesions CLE patients with systemic (SLE) attending tertiary care hospital India. In this prospective, cross-sectional study, 93 SLE were recruited. scores (LE)-specific skin done 75 SLE. mean score was 15.4 ±...
HLA-DRB1*04, -DRB1*08, -DRB1*14, -DQB1*03 and -DQB1*05 are reported to have significant association with pemphigus vulgaris; however, this is partially dependent on ethnicity. This study was done determine the HLA-DR -DQ types prevalent in Indian patients vulgaris.A prospective case-control for a period of 9 months Christian Medical College Vellore, India. HLA typing by PCR-SSOP method 50 cases healthy controls. Allele frequencies controls were compared odds ratios 95% confidence interval...
ABSTRACT Fibrosis is a result of chronically activated fibroblasts leading to the overproduction extracellular matrix (ECM), causing tissue hardening and loss organ function. Systemic sclerosis (SSc) fibrotic skin disease marked by inflammation, autoimmunity vasculopathy along with progressive fibrosis internal organs. A major bottleneck in understanding etiology SSc has been lack holistic animal model that can mimic human disease. We found transcription factor Snail overexpressed epidermis...
Lichen planopilaris is a form of lymphocyte-mediated primary cicatricial alopecia characterized by perifollicular scaling progressing to patches depending on the clinical variant. The course relentlessly progressive and chronic. Hence, early diagnosis institution therapy are imperative halt disease progress. Although definitive made scalp biopsy, detection usually delayed. Dermatoscopy helps in recognition this condition which at that stage clinically invisible. We report 23-year-old female...
Three histological subtypes of lymphomatoid papulosis (LyP), type A (histiocytic), B (mycosis fungoides like) and C (anaplastic large cell lymphoma are well recognized. Two new variants, D (simulating an aggressive epidermotropic cytotoxic lymphoma) E (angioinvasive type) has been described recently. We describe a 27-year-old man presented with history asymptomatic erythematous papules on both upper lower limbs noted since 10 years age. There were no systemic symptoms. Biopsy revealed...
Identification of CARD14-associated papulosquamous eruption (CAPE) is important as it helps in determining prognosis and management those affected. We report two siblings with genetically confirmed CAPE presenting treatment-resistant erythroderma one patient patterned psoriatic plaques facial predominance the other.