A5080700889- Hair Growth and Disorders
- Wound Healing and Treatments
- Wnt/β-catenin signaling in development and cancer
- Systemic Sclerosis and Related Diseases
- dental development and anomalies
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Kruppel-like factors research
- Dermatological and COVID-19 studies
- Skin Protection and Aging
- Enzyme Structure and Function
- Angiogenesis and VEGF in Cancer
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- RNA regulation and disease
- Viral Infections and Outbreaks Research
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- Mast cells and histamine
- Calpain Protease Function and Regulation
- Cellular Mechanics and Interactions
- Lymphatic System and Diseases
- Gene Regulatory Network Analysis
- Cell Image Analysis Techniques
University of California, San Francisco
2019-2024
Institute for Stem Cell Biology and Regenerative Medicine
2017-2023
Manipal Academy of Higher Education
2017-2018
Indian Institute of Science Education and Research Kolkata
2013
Augusta University
2000
The cutaneous wound-healing program is a product of complex interplay among diverse cell types within the skin. One fundamental process that mediated by these reciprocal interactions mobilization local stem pools to promote tissue regeneration and repair. Using ablation epidermal caspase-8 as model wound healing in Mus musculus, we analyzed signaling components responsible for epithelial proliferation. We found IL-1α IL-7 secreted from keratinocytes work tandem expand activated population...
Fibrosis is a prevalent pathological condition arising from the chronic activation of fibroblasts. This results extensive intercellular crosstalk mediated by both soluble factors and direct cell-cell connections. Prominent among these are interactions fibroblasts with immune cells, in which fibroblast-mast cell connection, although acknowledged, relatively unexplored. We have used Tg mouse model skin fibrosis, based on expression transcription factor Snail epidermis, to probe mechanisms...
The collagen contraction assay is an in vitro, three-dimensional method to determine the factor(s) affecting contractile behavior of activated cells such as fibroblasts either physiological or pathological scenarios. lattices/hydrogels are seeded with mimic interactions between these and their surrounding extracellular matrix proteins connective tissue. This important platform assess components potential therapeutic targets prevent pathologies fibrosis, which manifestations hyperactivated...
ABSTRACT The wound-healing process is a paradigm of the directed migration various pools stem cells from their niche to site injury where they replenish damaged cells. Two decades have elapsed since observation that wounding activates multipotent hair follicle infiltrate epidermis, but cues coax these out remains unknown. Using an excisional wound and genetic mouse models healing, we discovered Caspase-1, protein classically known as integral component cytosolic inflammasome, secreted has...
ABSTRACT Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes onset fibrosis we observed that this phenomenon recapitulated in Snail transgenic mouse model SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction leakage. Our investigation into mechanism phenotype revealed Angiopoietin-like...
Conference Abstract| October 01 2000 Oligomerization and Chaperone Function of Site-Directed Mutants R112C, R116C, R117C R119C AlphaA-Crystallin E. C. Abraham; Abraham 1Department Biochemistry Molecular Biology, Medical College Georgia, Agusta, Georgia 30912–2100, USA Search for other works by this author on: This Site PubMed Google Scholar S. M. Cherian-Shaw; Cherian-Shaw N. P. Shroff Biochem Soc Trans (2000) 28 (5): A258. https://doi.org/10.1042/bst028a258c Views Icon Article contents...