A5053614054- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- Virus-based gene therapy research
- DNA and Nucleic Acid Chemistry
- Membrane Separation Technologies
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Kruppel-like factors research
- Advanced Nanomaterials in Catalysis
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial Peptides and Activities
- Polymer-Based Agricultural Enhancements
- Insect and Pesticide Research
- Glycosylation and Glycoproteins Research
- Cholinesterase and Neurodegenerative Diseases
- Silk-based biomaterials and applications
- Pesticide Exposure and Toxicity
- Systemic Sclerosis and Related Diseases
- Nanoplatforms for cancer theranostics
- Viral Infectious Diseases and Gene Expression in Insects
- Ferroptosis and cancer prognosis
Institute for Stem Cell Biology and Regenerative Medicine
2023-2025
National Institute of Technology Warangal
2017-2024
Kaohsiung Medical University
2021-2024
Zero to Three
2021
Abstract Farmers from South Asian countries spray insecticides without protective gear, which leads to insecticide exposure through dermal and nasal routes. Acetylcholinesterase plays a crucial role in controlling neuromuscular function. Organophosphate carbamate inhibit acetylcholinesterase, severe neuronal/cognitive dysfunction, breathing disorders, loss of endurance, death. To address this issue, an Oxime-fabric is developed by covalently attaching silyl-pralidoxime the cellulose fabric....
Due to their high affinity for sialic acid (SA), which is commonly overexpressed in malignant cells, phenylboronic (PBA)-decorated nanoparticles efficiently transfer genes the desired region. These can have unique applications drug/gene delivery research.
Cationic gemini lipopeptides are a relatively new class of amphiphilic compounds to be used for gene delivery. Through the possibility incorporating short peptides with cell-penetrating functionalities, these may advantageous over traditional cationic lipids. Herein, we report design, synthesis, and application novel lipopeptide An ultrashort peptide, containing four amino acids, arginine-cysteine-cysteine-arginine, serves as head group, two α-tocopherol moieties act hydrophobic anchoring...
Spacer dependent variation of the lipoplex size and transfection gemini lipids with delocalizable cationic head groups.
Nonviral lipid-based vectors are promising transporting systems for the intracellular delivery of therapeutic gene sequences and directly influence success delivery. However, associated drawbacks like lower transfection, toxicity, targetability require further improvement. Thus, herein, we report a novel lipid formulation by mixing two distinct cationic surfactants such as tocopheryl succinate based 1,12 dodecane bolaamphiphile prove it to be good transfection reagent with its competing...
Cationic lipids have been effectively used as nonviral vectors for the delivery of polynucleic acids into cytosol.
Abstract:: Targeted gene and drug delivery vector developments have completely changed the therapeutic intervention by providing previously unheard-of levels of accuracy efficacy in treating various illnesses. Cancer is one such fatal disease plaguing people across globe. This review article highlights potential uses targeted systems field cancer treatment while a thorough examination state art. Chemotherapy radiation therapy are being used to cure cancer, yet they can be frequently...
Abstract The liposomal systems proved remarkably useful for the delivery of genetic materials but enhancing their efficacy remains a significant challenge. While structural alterations could result in discovery more effective transfecting lipids, improving widely used lipid carriers is also crucial order to compete with viral vectors gene delivery. Herein, we developed formulations commercially available lipid, 1,2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP) synthetic amino acid based...
Abstract Sugar based cationic lipids are promising carriers of nucleic acids into various cells. Particularly, abundant hydroxyl functional groups in the sugar‐like moieties believed to enhance target oriented uptake as well biocompatibility. Towards this direction, we have synthesized three new lipid analogues with or without multi‐hydroxyl head groups. Liposomal formulations these were developed and thoroughly characterized by means DNA binding ability, size zeta potential. Optimal...
ABSTRACT Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes onset fibrosis we observed that this phenomenon recapitulated in Snail transgenic mouse model SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction leakage. Our investigation into mechanism phenotype revealed Angiopoietin-like...