A5042804833- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Ferroptosis and cancer prognosis
- Neuroscience and Neural Engineering
- Nicotinic Acetylcholine Receptors Study
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
University of Chile
2021-2025
University of Würzburg
2025
Instituto de Neurociencia Biomédica
2022
Significance The expression of genes involved in hippocampal synaptic plasticity, learning, and memory requires that Ca 2+ signals generated spines, dendrites, or the soma by neuronal stimulation reach nucleus. Here, we report neurons induces release mediated RyR2 channels, which contributes to nuclear signal generation. Suppression RyR-mediated inhibited activity-induced phosphorylation transcriptional regulator CREB Npas4 transcription factor RyR2, play crucial roles processes. We propose...
Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition peroxidase 4 (GPX4), key intracellular antioxidant regulator, promotes ferroptosis in different types. Scant information available on GPX4-induced hippocampal neurons. Moreover, role calcium (Ca2+) signaling remains elusive. Here, we report that RSL3, selective...
Hippocampal neuronal activity generates dendritic and somatic Ca2+ signals, which depending on stimulus intensity, rapidly propagate to the nucleus induce expression of transcription factors genes with crucial roles in cognitive functions. Soluble Amyloid-beta Oligomers (AβOs), main synaptotoxins engaged pathogenesis Alzheimer's disease, generate aberrant signals primary hippocampal neurons, increase their oxidative tone disrupt structural plasticity. Here, we explored effects...
Hippocampal neuronal activity generates dendritic and somatic Ca2+ signals, which, depending on stimulus intensity, rapidly propagate to the nucleus induce expression of transcription factors genes with crucial roles in cognitive functions. Soluble amyloid-beta oligomers (AβOs), main synaptotoxins engaged pathogenesis Alzheimer's disease, generate aberrant signals primary hippocampal neurons, increase their oxidative tone disrupt structural plasticity. Here, we explored effects sub-lethal...