A5029733700- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Breast Cancer Treatment Studies
- Research on Leishmaniasis Studies
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Lipid metabolism and disorders
- Parasitic Infections and Diagnostics
- Estrogen and related hormone effects
- Chemical Reaction Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Text Analysis Techniques
- Complementary and Alternative Medicine Studies
- Empathy and Medical Education
- BRCA gene mutations in cancer
- RNA regulation and disease
- Psychosomatic Disorders and Their Treatments
- Therapeutic Uses of Natural Elements
- Breast Lesions and Carcinomas
- Alcohol Consumption and Health Effects
- Advanced Chemical Physics Studies
- Pancreatic and Hepatic Oncology Research
Instituto de Investigación Sanitaria de Santiago
2020-2021
Servicio Gallego de Salud
2012-2016
Ayuntamiento de Bilbao
2014-2016
University Hospital Complex Of Vigo
2009-2013
Fundación Pública Galega de Medicina Xenómica
2012
Universidad de León
2006-2007
Universidad de León
2007
University College London
2000
Abstract Multiple studies have found the neutrophil to lymphocyte ratio (NLR) be associated with adverse breast cancer (BC) prognosis and survival. Very limited data exist on role of NLR risk BC. The BREOGAN study is a population-based case–control conducted in Galicia, Spain. We examined WBC- NLR-BC relationships. BC increased increasing levels neutrophils percentage (NE%) (multivariable OR for highest category (95% CI) = 2.14 (1.39–3.32), P-trend < 0.001) 1.93 (1.26–2.97), 0.001)....
Background Differences in the incidence and outcome of breast cancer among Hispanic women compared with white are well documented likely explained by ethnic differences genetic composition, lifestyle, or environmental exposures. Methodolgy/Principal Findings A population-based study was conducted Galicia, Spain. total 510 diagnosed operable invasive between 1997 2010 participated study. Data on demographics, risk factors, clinico-pathological characteristics were collected. The different...
Background Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast among Hispanic women. Materials and Methods A population-based study was conducted city Santiago de Compostela, Spain. total 645 women diagnosed with operable invasive between 1992 2005 participated study. Data on demographics, risk...
Background Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was confirm association between SNPs and in multi-center Colon Cancer Family Registry. Materials Methods 23 tagging gene were genotyped among 1,592 population-based 253 clinic-based families. The SNP-colorectal associations assessed multivariable conditional logistic regression. Results Among families, both rs12953717 (odds ratio, 1.29; 95% confidence...
Although alcohol intake is an established risk factor for overall breast cancer, few studies have looked at the relationship between use and cancer by four major subtypes of very data exist in alcohol-breast Spanish women. A population-based case-control study was conducted Galicia, Spain. total 1766 women diagnosed with invasive 1997 2014 833 controls participated study. Data on demographics, factors, clinico-pathological characteristics were collected. We examined association according to...
As obesity, circulating lipids and other vascular/metabolic factors influence the risk of stroke, we examined if genetic variants associated with these conditions are related to stroke using a case-control study in Galicia, Spain. A selection 200 single-nucleotide polymorphisms previously found be body mass index, lipids, type 2 diabetes, heart failure, obesity-related cancer cerebral infarction were genotyped 465 patients diagnosed 480 population-based controls. An unsupervised Lasso...
Experimental data showed that endothelial lipase (LIPG) is a crucial player in breast cancer. However, very limited exists on the role of LIPG risk cancer humans. We examined LIPG-breast association within our population-based case-control study from Galicia, Spain, BREOGAN (BREast Oncology GAlicia Network). Plasma and/or OxLDL were measured 114 cases and 82 controls study, included present study. The increased with increasing levels (multivariable OR for highest category (95% CI) 2.52...
Abstract Background Although alcohol intake is an established risk factor for overall breast cancer, few studies have looked at the relationship between use and cancer by subtype of cancer. Materials Methods A population-based study was conducted in Galicia, Spain. total 1211 Spanish women diagnosed with operable invasive 1997 2010 550 controls participated study. Data on demographics, factors, clinico-pathological characteristics were collected. The four major subtypes...
Abstract Background. Impaired function of JAnus Kinase/Signal Transducer and Activator Transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency; genetic variation in this could affect breast cancer risk. Methods. We evaluated associations between polymorphisms (SNPs) 14 the JAK/STAT (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, SCOS4, APOBEC ADAR) risk using data from OncoArray. As interacts with ER PR, we also examined these by subtype. a...