A5050038528- Global Peace and Security Dynamics
- International Development and Aid
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
Sarah Cannon Research Institute
2022
PURPOSE Testing to measure homologous repair deficiency (HRD) in certain cancers can identify patients who may benefit from poly(ADP-ribose) polymerase inhibitors. We examined real-world patterns and factors associated with testing HRD (eg, BRCA1 / 2 , loss of heterozygosity, genomic instability) epithelial ovarian cancer (EOC) mutations human epidermal growth factor receptor 2–negative metastatic breast (mBC) their prevalence. METHODS described demographic clinical characteristics diagnosed...
Background: Standard of care treatment for diffuse large B-cell lymphoma type Richter transformation (DLBCL-RT) is combination chemo-immunotherapy but limited by poor response rates and lack durability. Recent studies have shown some clinical benefit with PD-1 blockade in DLBCL-RT including deep responses, highlighting that T-cell targeted immunotherapy may improve outcomes. Casitas B-lineage proto-oncogene B (CBL-B) an E3 ubiquitin ligase expressed multiple immune cell lineages, which...