A5101669153- Cellular Mechanics and Interactions
- Child and Adolescent Psychosocial and Emotional Development
- Educational and Psychological Assessments
- Family and Disability Support Research
- Behavioral and Psychological Studies
- Neurobiology and Insect Physiology Research
- Collaborative Teaching and Inclusion
- Substance Abuse Treatment and Outcomes
- Developmental Biology and Gene Regulation
- Teacher Education and Leadership Studies
- Education Systems and Policy
- Disability Education and Employment
- Educational Assessment and Improvement
- Redox biology and oxidative stress
- Homelessness and Social Issues
- Ion Transport and Channel Regulation
- Neurobiology of Language and Bilingualism
- Silk-based biomaterials and applications
- Social Sciences and Governance
- Advanced Breast Cancer Therapies
- Financial Literacy, Pension, Retirement Analysis
- Cholesterol and Lipid Metabolism
- Barrier Structure and Function Studies
- Biocrusts and Microbial Ecology
- Morphological variations and asymmetry
University of Cambridge
2021-2024
University of Illinois Urbana-Champaign
2022-2023
Institute of Cancer Research
2022
Observational & Pragmatic Research Institute
2017
University of Glasgow
2005-2008
Newcastle University
2004
Institute of Educational Policy
2004
University of London
2001
Universidad de Londres
2001
Abstract There has been a recent increase in interest the research review as method of presenting cumulative data about effects educational policies and practices. This is part wider movement ‘evidence‐informed policy‐making’ espoused by current Government. In part, sparked perceived success Cochrane Collaboration medicine, which set up framework for conducting verifying systematic reviews meta‐analyses random controlled trials medical interventions. A pilot project to apply methods carried...
Guanosine 3'-5' cyclic monophosphate (cGMP) and adenosine (cAMP) are important regulators of cell tissue function. However, cGMP cAMP transport have received relatively limited attention, especially in model organisms where such studies can be conducted vivo. The Drosophila Malpighian (renal) tubule transports utilises these as signalling molecules. We show here via substrate competition drug inhibition that - but not requires the presence di- or tri-carboxylates; both nucleotides occurs ATP...
Insect Malpighian (renal) tubules are capable of transporting fluid at remarkable rates. Secondary active transport potassium the apical surface principal cell must be matched by a high-capacity basolateral entry route. A recent microarray analysis Drosophila tubule identified three extremely abundant and enriched K(+) channel genes encoding inward rectifier channels Drosophila: ir, irk2 irk3. Enriched expression in was verified quantitative RT-PCR, all IRKs localised to cells main segment...
Secretory pathway Ca 2+ /Mn -ATPases (SPCAs) are important for maintenance of cellular and Mn homeostasis, and, to date, all SPCAs have been found localize the Golgi apparatus. The single Drosophila SPCA gene ( SPoCk) was identified by an in silico screen novel -ATPases. It encoded three SPoCk isoforms with novel, distinct subcellular specificities endoplasmic reticulum (ER) peroxisomes addition Golgi. Furthermore, expression peroxisome-associated isoform sexually dimorphic. Overexpression...
Federal research regulations require participants to be informed about whether medical care or compensation for injury is available in more than minimal risk studies and prohibit language consent documents that waives, appears waive, legal rights. The objectives of this study were compare data collected 2000 2012 identify significant changes types institutional policies at U.S. institutions, assess the relationship between characteristics different policies. We found research-related did not...
Compartmental boundaries physically separate developing tissues into distinct regions, which is fundamental for the organisation of body plan in both insects and vertebrates. In many examples, this physical segregation caused by a regulated increase contractility actomyosin cortex at boundary cell-cell interfaces, property important developmental morphogenesis beyond compartmental formation. We performed an unbiased screening approach to identify cell surface receptors required enrichment...
Background: Standard of care treatment for diffuse large B-cell lymphoma type Richter transformation (DLBCL-RT) is combination chemo-immunotherapy but limited by poor response rates and lack durability. Recent studies have shown some clinical benefit with PD-1 blockade in DLBCL-RT including deep responses, highlighting that T-cell targeted immunotherapy may improve outcomes. Casitas B-lineage proto-oncogene B (CBL-B) an E3 ubiquitin ligase expressed multiple immune cell lineages, which...
Abstract As tissues grow and change shape during animal development, they physically pull push on each other these mechanical interactions can be important for morphogenesis. During Drosophila gastrulation, mesoderm invagination temporally overlaps with the extension of ectodermal germband; latter is caused primarily by Myosin II-driven polarised cell intercalation. Here we investigate impact ectoderm extension, examining possible mechanotransductive effects II recruitment We find that...
Summary: Purpose: We tested whether the behavioral components of an Intracarotid Amobarbital Protocol (IAP) had criterion validity. It was hypothesized that a recognition‐memory test designed for intracarotid injections and used to predict risk global amnesia before elective temporal lobectomy should also identify persons who are severely amnesic due other neurologic causes. Divergent validity predicts speech tasks would be unaffected by amnesia. Test‐retest reliability measured. Methods:...
Abstract BACKGROUND While there is some research on adult recovery from substance use, particularly regarding its definition and correlates, appears to be little work defining for adolescents. Definitional adolescent recovery, including adolescents’ perceptions of will create opportunities enhance recovery-oriented systems care. METHODS Data this study were collected through Qualtrics, an online survey platform. The gathered different behavioral social indicators, whether adolescents...
Abstract Compartmental boundaries physically separate groups of epithelial cells, a property fundamental for the organization body plan in both insects and vertebrates. In many examples, this physical separation has been shown to be consequence regulated increase contractility actomyosin cortex at boundary cell-cell interfaces, important developmental morphogenesis beyond compartmental formation. study, we took an unbiased screening approach identify cell surface receptors required...