A5005026409- Nanoparticle-Based Drug Delivery
- Reproductive tract infections research
- Tuberculosis Research and Epidemiology
- Nanoplatforms for cancer theranostics
- Characterization and Applications of Magnetic Nanoparticles
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Microfluidic and Bio-sensing Technologies
- Syphilis Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Amoebic Infections and Treatments
- Insect Pest Control Strategies
- Animal health and immunology
- Parasitic Infections and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Insect and Pesticide Research
- Microbial infections and disease research
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Vector-borne infectious diseases
- Viral Infections and Immunology Research
- Microbial Inactivation Methods
Secretaría de Salud de Jalisco
2013-2025
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco
2015-2025
Pharmaceutical Biotechnology (Czechia)
2015-2018
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2016
Consejo Nacional de Ciencia y Tecnología
2014
Instituto Politécnico Nacional
2003-2004
Center for Research and Advanced Studies of the National Polytechnic Institute
2003-2004
Mexican Social Security Institute
1995
Studies have noted the connection between Mycobacterium avium subspecies paratuberculosis (MAP) and autoimmunity. MAP is an intracellular pathogen that infects multiplies in macrophages. To overcome hostile environment elicited by macrophage, secretes a battery of virulence factors to neutralize toxic effects macrophage. One Protein Tyrosine Phosphatase A (PtpA), protein secreted interferes phago-lysosome fusion, rendering unnoticed cytoplasm This study aimed assess presence PtpA antibodies...
Androgen receptor mutations, particularly T877A and W741L, promote prostate cancer (PCa). The main therapies against PCa use androgen (AR) antagonists, including Bicalutamide; but these drugs lose their effectiveness over time. Chrysin is a flavonoid with several biological activities, antitumoral properties; however, its potential as an antiandrogen must be explored. present study aimed to characterize compare the molecular interactions of chrysin wild-type mutated ARs cytotoxic effect in...
The UCNPs-ZnPc-Trastuzumab nanocomplex tracks and kills HER2-positive breast cancer cells upon NIR-excitation.
Cervical cancer (CC) is a serious global health issue, and it well-known that HPV infection the main etiological factor triggers carcinogenesis. In cancer, chemokine ligands receptors are involved in tumor cell growth, metastasis, leukocyte infiltration, angiogenesis; however, information on role played by E6/E7 of HPV16/18 modulation chemokines very limited. Therefore, this study aimed to determine whether differentially expressed CC-derived lines; if oncoproteins from HPV16 18 capable...
Epidermal growth factor receptor 2 (HER2) is the second target molecule most commonly used in breast cancer treatment. Both recurrence and metastasis are still deadly for HER2+ patients. Hydrogels can be an option developing three-dimensional (3D) cell culture systems that resemble tumor features better than monolayer cultures could preclinical screening new biotherapeutics. Biopolymers (gelatin alginate) were to develop a hydrogel capable of encapsulating living cells BT-474/GFP. The was...
Assembly of recombinant capsid proteins into virus-like particles (VLPs) still represents an interesting challenge in virus-based nanotechnologies. The structure VLPs has gained importance for the development and design new adjuvants antigen carriers. potential Tobacco etch virus protein (TEV CP) as adjuvant not been evaluated to date.Two constructs TEV CP expression Escherichia coli were generated: a wild-type version (TEV-CP) C-terminal hexahistidine (His)-tagged (His-TEV-CP). Although...
A ferrofluid with 1,2-Benzenediol-coated iron oxide nanoparticles was synthesized and physicochemically analyzed. This colloidal system prepared following the typical co-precipitation method, superparamagnetic of 13.5 nm average diameter, 34 emu/g magnetic saturation, 285 K blocking temperature were obtained. Additionally, zeta potential showed a suitable stability for cancer therapy assays magneto-calorimetric trails determined high power absorption density. In addition, oxidative...
During the COVID-19 pandemic, Ad5-nCoV vaccine was applied to Mexican population before WHO approved it. In a transversal study, we compare CanSino efficacy and natural SARS-CoV-2 infection in eliciting neutralizing antibodies against Delta variant Guadalajara, Mexico. Participants between 30–60 years were included study classified into three groups: 1) Natural immunity (unvaccinated), 2) Vaccine-induced (vaccinated individuals without history), 3) + vaccine-induced immunity. These groups...
In this work, the cell line SW620-GFP has been used in a complete magnetic hyperthermia assay, from preparation of ferrofluid with folate-coated iron oxide nanoparticles to vivo experiments. The physical and chemical characterization evidenced their superparamagnetic behaviour, an average diameter 12 ± 4 nm, 2 nm coat thickness, high-power loss density. main innovation work is exclusive capability viable cells emit fluorescence, enabling fast analysis both, viability vitro epifluorescence...
Cell spheroids are an important three-dimensional (3D) model for in vitro testing and gaining interest their use clinical applications. More natural 3D cell culture environments that support cell–cell interactions have been created cancer drug discovery therapy applications, such as the scaffold-free Petri Dish® technology. This technology uses reusable autoclavable silicone micro-molds with different topographies, it conventionally gelled agarose hydrogel formation to preserve topography of...
Abstract Porcine circovirus type 2 (PCV2) still represents a major problem to the swine industry worldwide, causing high mortality rates in infected animals. Virus‐like particles (VLPs) have gained attention for vaccine development, serving both as scaffolds epitope expression and immune response enhancers. The commercial subunit vaccines against PCV2 consist of VLPs formed by self‐assembly capsid protein (CP) expressed baculovirus vector system. In this work, protective was inserted into...
Background: Several studies have shown that patients with cancer antibodies in serum react cellular autoantigens, known as Tumor-Associated Antigens (TAA). The present work aimed to determine whether a mini-array comprising four recombinant TAA increases the detection of specific for diagnosis early-stage breast cancer. Methods: included Alpha 1-AntiTrypsin (A1AT), TriosePhosphate Isomerase 1 (TPI1), Peptidyl-Prolyl cis-trans A (PPIA), and PeroxiReDoXin 2 (PRDX2) full-length proteins....
Abstract Ditaxis heterantha is a plant of the Euphorbiaceae family that grows in semiarid regions Mexico. It produces yellow pigmented seeds are used for coloring foods. The contain about 20% proteins. Proteins D. were extracted and fractionated on basis solubility. Three main protein fractions obtained: glutelins, 488 ± 0.5; albumins, 229 2; total globulins, 160 1 g/kg. amino acid profile was evaluated each fraction isolated, where isolate contains essential acids such as Val, Phe, Tyr,...
In this work, tetrahydroxyquinone (THQ) was used for the first time to coat iron oxide nanoparticles (IONPs) and carry out in vitro experiments magnetic hyperthermia. Synthesis by co-precipitation resulted spherical IONPs with a core diameter of 13 ± 3 nm covered 0.5 thick THQ, which provided them reasonably good zeta potential ζ = −28 2 mV at pH 7.3, thus colloidal stability. The properties THQ-coated are promising: low coercive field Hc 7 Oe, high saturation Ms 70.5 emu/g blocking...