A5066484425- Connexins and lens biology
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiac pacing and defibrillation studies
- Neurological disorders and treatments
- RNA regulation and disease
- Advanced Fluorescence Microscopy Techniques
- Cardiac Arrhythmias and Treatments
- Photoacoustic and Ultrasonic Imaging
- Ion channel regulation and function
- RNA Research and Splicing
- Advanced Electron Microscopy Techniques and Applications
- Optical Coatings and Gratings
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Ion Channels and Receptors
- Photonic and Optical Devices
- Cellular transport and secretion
- Optical Coherence Tomography Applications
- Nicotinic Acetylcholine Receptors Study
- Acute Myocardial Infarction Research
- Microtubule and mitosis dynamics
- Electrowetting and Microfluidic Technologies
- Nanoplatforms for cancer theranostics
- Pickering emulsions and particle stabilization
- Material Dynamics and Properties
Centro de Investigaciones en Optica
2016-2024
Deakin University
2019
Beijing University of Chemical Technology
2019
University of Göttingen
2012-2014
Howard Hughes Medical Institute
2012
Veneto Institute of Molecular Medicine
2003-2006
Tecnologie Avanzate (Italy)
2006
Istituto Nazionale per la Fisica della Materia
2003
Mutations in the GJB2 gene, which encodes gap junction protein connexin26 (Cx26), are major cause of genetic non-syndromic hearing loss. The role allelic variant M34T causing hereditary deafness remains controversial. By combining genetic, clinical, biochemical, electrophysiological and structural modeling studies, we have re-assessed pathogenetic mutation. Genetic audiological data indicate that majority heterozygous carriers all five compound heterozygotes exhibited an impaired auditory...
The UCNPs-ZnPc-Trastuzumab nanocomplex tracks and kills HER2-positive breast cancer cells upon NIR-excitation.
Mutations in the gene (GJB2) coding for Connexin 26 (Cx26) are responsible genetic forms of sensorineural hearing loss. This article describes a family characterized by congenital profound loss, inherited an autosomal dominant fashion and associated to R75Q substitution Cx26. Cell transfection fluorescence imaging, dye transfer experiments dual patch clamp recording showed that mutant completely prevents formation functional channels despite assembling into junctional plaques, communication...
Hair cell stereocilia are crucial for hearing and the sense of balance. They include an array accurately packed, parallel actin filaments act as levers, which transform mechanical deformation into neuronal signals. The length vestibular reaches several micrometers, whereas, individual microfilaments, diameter therefore characteristic scale in lateral direction is on order a few nanometers. These orders magnitude render X-rays ideal tool investigating packing, numerous studies reconstituted...
We report an experimental and theoretical investigation of glass formation in soft thermo-sensitive colloids following two different routes: a gradual increase the particle number density at constant temperature radius fixed volume density. Confocal microscopy experiments non-equilibrium self-consistent generalized Langevin equation (NE-SCGLE) theory consistently show that routes lead to dynamically comparable state sufficiently long aging times. However, reveal presence moderate but...
Tubulinopathies are a group of recently described diseases characterized by mutations in the tubulin genes. Mutations TUBB4A produce such as dystonia 4 (DYT4) and hypomyelination with atrophy basal ganglia cerebellum (H-ABC), which clinically diagnosed magnetic resonance imaging (MRI). We propose taiep rat first animal model for tubulinopathies. The spontaneous mutant suffers from syndrome related to central leukodistrophy tremor, ataxia, immobility, epilepsy paralysis. clinical signs...
Cysteine-rich receptor-like kinases (CRKs) are a type of (RLKs) that important for pathogen resistance, extracellular reactive oxygen species (ROS) signaling, and programmed cell death in plants. In previous study, we identified 46 CRK family members the Phaseolus vulgaris genome found CRK12 was highly upregulated under root nodule symbiotic conditions. To better understand role Phaseolus-Rhizobia interaction, functionally characterized this gene by overexpressing (CRK12-OE) silencing...
Abstract Hypomyelination with atrophy of the basal ganglia and cerebellum (H‐ABC) is a neurodegenerative disease due to mutations in TUBB4A. Patients suffer from extrapyramidal movements, spasticity, ataxia, cognitive deficits. Magnetic resonance imaging features are hypomyelination striatum cerebellum. A correlation between their cellular, tissue organic effects largely missing. The these on sensory functions have not been described so far. We previously reported rat carrying TUBB4A (A302T)...
The use of electronic devices to measure Relative Humidity (RH) is widespread. However, under certain circumstances, for example when explosive gases are present, a spark-free method should be used. Here we suggest the stimuli-responsive materials, like gelatin and interpenetrated polymers, detect RH with an optical method. These materials hydrophilic. When water vapor absorbed by films molecules attach molecular network. result that film thickness increases their refractive index changes....
We developed two versions of refractometers to measure the refractive index liquids. One refractometer comprises a glass cell with surface relief grating on inner face one its walls, while other is microfluidic channel in form serpentine that behaves as grating. Measurements liquid were performed by sensing first order intensity. Several liquids have been used including an organic one. Calibration plots are shown.
The present study reports the localization and interaction of thioglycolic acid (TGA) capped CdTe quantum dots (TGA@CdTe QDs) within extracellular matrix (ECM) Haematococcus pluvialis (Chlorophyceae) microalgae (HPM) after an incubation period 5 min. Changes in Raman spectrum HPM induced by adsorption TGA@CdTe QDs are successfully found using naked gold anisotropic structures as nano-sensors for surface-enhanced scattering (SERS effect). spectroscopy results show that interact with...
High resolution fluorescence microscopy requires optimization of the protocols for biological sample preparation. The optical and chemical characteristics mounting media are among things that could be modified to achieve optimal image formation. In our search substances perform as media, 3,3'-thiodipropanol (TDP) emerged a sulfide with potentially interesting characteristics. this work, several tests its performance medium samples were performed, including labeling filamentous actin...
The taiep rat is a tubulin mutant with an early hypomyelination followed by progressive demyelination of the central nervous system due to point mutation in Tubb4a gene. It shows clinical, radiological, and pathological signs like those human leukodystrophy atrophy basal ganglia cerebellum (H-ABC). Taiep rats had tremor, ataxia, immobility episodes, epilepsy, paralysis; acronym these given name this autosomal recessive trait. aim study was analyze characteristics somatosensory evoked...