A5040108878- Spectroscopy Techniques in Biomedical and Chemical Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Wound Healing and Treatments
- COVID-19 and Mental Health
- Stress and Burnout Research
- Medicinal Plants and Neuroprotection
- COVID-19 diagnosis using AI
- Resilience and Mental Health
- Nanoparticles: synthesis and applications
- Animal Virus Infections Studies
- Vitamin C and Antioxidants Research
- Pluripotent Stem Cells Research
- Healthcare professionals’ stress and burnout
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- COVID-19 Impact on Reproduction
- Infrared Thermography in Medicine
- Vitamin D Research Studies
- Health and Lifestyle Studies
- Sepsis Diagnosis and Treatment
- Bone Tissue Engineering Materials
- vaccines and immunoinformatics approaches
Hospital Central Militar
2019-2024
Secretaría de la Defensa Nacional
2019-2024
Universidad del Ejército y Fuerza Aérea
2019-2024
Ministerio de Defensa
2024
Instituto Politécnico Nacional
2022-2023
Secretaria de Salud
2021-2023
Tecnológico Nacional de México
2023
Secretaria de Salud
2019
Abstract The coronavirus disease 2019 (COVID-19) is the latest biological hazard for novel severe acute respiratory syndrome 2 (SARS-CoV-2). Even though numerous diagnostic tests SARS-CoV-2 have been proposed, new diagnosis strategies are being developed, looking less expensive methods to be used as screening. This study aimed establish salivary vibrational modes analyzed by attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy detect COVID-19 fingerprints that allow...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing death of 5 million people worldwide. The genetic background represents a factor that predisposes way host responds to SARS-CoV-2 infection. In this sense, variants ACE ACE2 could explain observed interindividual variability COVID-19 outcomes. order improve understanding how are involved in severity COVID-19, we included...
Breast cancer (BC) is a malignant disease with high prevalence worldwide. The main cause of death not the primary tumor, but instead spread tumor cells to distant sites. aim present study was examine new method for detection in aqueous medium using bioimpedance spectroscopy assisted magnetic nanoparticles (MNP's) exposure constant field. spectroscopic patterns were identified three breast cell lines. Each BC line represents different pathologic stage: early stage (MCF-7), invasive phase...
Abstract Cytokines and chemokines are essential for establishing an appropriate immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Variations in the genes encoding cytokines strongly influence pathogenic challenges disease outcomes. This study was carried out determine associations of polymorphisms TNF -α , IL-6 IL-8, IL-10 CCL5 with COVID-19 severity. A total 627 unvaccinated patients were classified according WHO We evaluated levels IFN-α, IFN-γ, TNF-α, IL-1R,...
Diabetes is a chronic degenerative disease that carries multiple complications. One of the most important complications diabetic cutaneous complications, such as skin lesions, ulcerations, and foot, which are present in 30%-70% patients. Currently, treatments for wound healing include growth factors cytokines, substitutes, hyperbaric oxygen therapy, grafts. However, these ineffective due to complex mechanisms involved developing unhealed wounds. Considering aforementioned regenerative...
The wide range of symptoms the coronavirus disease 2019 (COVID-19) makes it challenging to predict evolution using a single parameter. Therefore, describe pathophysiological response SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according survival or death, sociodemographic and clinical characteristics, biochemical immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples their correlation chemometric...
During a viral infection, the immune response is mediated by toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed lives of more than 6.8 million people around world. We carried out cross-sectional with population 618 SARS-CoV-2-positive unvaccinated subjects further classified based on severity: 22% were mild, 34% severe, 26% critical, 18% deceased. Toll Like Receptor 7 (TLR7) single-nucleotide...
Various immunopathological events characterize the systemic acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Moreover, it has been reported that disease 2019 (COVID-19) vaccination and infection by SARS-CoV-2 induce humoral immunity mediated B-cell-derived antibodies cellular T cells memory B cells. Immunoglobulins, cytokines, chemokines play an important role in shaping response to vaccination. Furthermore, different vaccines have developed prevent COVID-19. Therefore, this...
Introduction . The acute kidney injury (AKI) is characterized by a sudden glomerular filtration reduction. Renal or intrinsic causes of AKI include nephrotoxicity induced exogenous agents like cisplatin, which oxidative stress altering the biochemical process and leading to apoptosis. Therefore, this research aimed at analyzing embryonic stem cells (ESC) nephroprotective effect in employing genetic, phenotypic, microspectroscopic techniques. Methods Thirty mice were randomly divided into...
(1) Background: Burnout syndrome (BOS) is defined as a psychological state of physical and mental fatigue associated with work. The COVID-19 pandemic greatly impacted the wellbeing health professionals. objective this work was to determine impact on personnel, monitoring frequency BOS throughout pandemic. (2) Methods: Maslach Inventory (MBI) self-applied in four periods according sociodemographic employment characteristics. In study, all hospital personnel were included; association sex,...
Gold nanoparticles (AuNPs) have been used in a wide range of applications, conferring to bio-molecules diverse properties such as delivery, stabilization, and reduction the adverse effects drugs or plant extracts. Polyphenolic compounds from Bacopa procumbens (B. procumbens) (BP) can modulate proliferation, adhesion, migration, cell differentiation, reducing artificial scratch area fibroblast cultures promoting wound healing an vivo model. Here, chemically synthesized AuNPs conjugated with...
Introducción: La enfermedad COVID-19 actualmente no tiene ningún tratamiento específico y cuenta con vacunación; la morbimortalidad de esta patología es elevada en México como a nivel mundial, por lo que primordial estudiar factores puedan modular el curso enfermedad. El papel vitamina D parece tener un fundamental inmunidad infecciones respiratorias. Objetivo: Determinar asociación entre los niveles mortalidad pacientes hospitalizados Hospital Central Militar. Material métodos: En este...
By end December of 2021, COVID-19 has infected around 276 million individuals and caused over 5 deaths worldwide. Infection results in dysregulated systemic inflammation, multi-organ dysfunction, critical illness. Cells the central nervous system are also affected, triggering an uncontrolled neuroinflammatory response. Low doses glucocorticoids, administered orally or intravenously, reduce mortality among moderate severe patients. However, low by these routes do not reach therapeutic levels...
Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (TMPRSS2) and serpine family E member 1 (SERPINE1) could help to elucidate the contribution variability COVID-19 outcomes. To evaluate genetic variants genes previously associated with outcomes, we performed cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. TMPRSS2 (rs2070788, rs75603675, rs12329760) SERPINE1 (rs2227631, rs2227667,...
Some studies have shown that silicon dioxide nanoparticles (SiO2-NPs) can reach different regions of the brain and cause toxicity; however, consequences SiO2-NPs exposure on diverse cell lineages is limited. We aimed to investigate neurotoxic effects SiO2-NP (0-100 µg/mL) rat astrocyte-rich cultures or neuron-rich using scanning electron microscopy, Attenuated Total Reflection-Fourier Transform Infrared spectroscopy (ATR-FTIR), FTIR microspectroscopy mapping (IQ mapping), viability tests....
Gold nanoparticles (AuNPs) have been used in a broad range of applications conferring to bio-molecules diverse proprieties such as deliver, stabilization and reduction adverse effects drugs or plant ex-tracts. Polyphenolic compounds from Bacopa procumbens (BP) are able modulate proliferation, adhesion, migration cell differentiation, reducing artificial scratch area fibroblast cultures promoting wound healing vivo model. Here, chemically synthetized AuNPs conjugated with BP (AuNP-BP) were...
Wounds represent a medical problem that contributes importantly to patient morbidity and healthcare costs in several pathologies. In Hidalgo, Mexico, the Bacopa procumbens plant has been traditionally used for wound-healing care generations; vitro vivo experiments were designed evaluate effects of bioactive compounds obtained from B. aqueous fraction determine key pathways involved wound regeneration. Bioactive characterized by HPLC/QTOF-MS, proliferation, migration, adhesion,...
La cicatrización de la piel es un proceso complejo y organizado que involucra tres fases: inflamatoria, proliferativa remodelación. Es indispensable el análisis este biomolecularmente para investigar proponer nuevas estrategias terapéuticas mejoren o promuevan regeneración. El objetivo proyecto fue analizar histológica mediante microespectroscopía infrarroja por transformada Fourier (MFTIR) su función mapeo bioquímico, muestras lesiones excisionales piel, comparando los cambios morfológicos...
Wounds represents a medical problem that contribute importantly to patient morbidity and the healthcare costs in several pathologies. In Hidalgo, Mexico, Bacopa procumbens plant has been traditionally used for wound healing care generations; vitro vivo experiments were design evaluate effects of bioactive compounds obtained from B. aquoethanolic extract determine key pathways involved regeneration. Bioactive characterized by HPLC- QTOF-MS proliferation, migration, adhesion, differentiation...
Abstract There is a growing trend in using saliva for SARS-CoV-2 detection with reasonable accuracy. We have studied the responses of IgA, IgG, and IgM human by directly comparing disease control analyzing two-trace two-dimensional correlation spectra (2T2D-COS) employing Fourier transform infrared (FTIR) spectra. The findings show decrease IgG salivary antibodies 50, 60, 65, 75-years samples. Among various COVID-19 populations studied, female 30 years group reveal defence mechanisms...