A5070204780- Parasitic infections in humans and animals
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Parasites and Host Interactions
- Amoebic Infections and Treatments
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Congenital Anomalies and Fetal Surgery
- Neuroinflammation and Neurodegeneration Mechanisms
- Mycobacterium research and diagnosis
- Peripheral Neuropathies and Disorders
- Antifungal resistance and susceptibility
- Parasite Biology and Host Interactions
- Cerebrospinal fluid and hydrocephalus
- Bacterial Infections and Vaccines
- Tryptophan and brain disorders
- Reproductive System and Pregnancy
- Fungal Infections and Studies
- Intensive Care Unit Cognitive Disorders
- Neurological Complications and Syndromes
- Parasitic Infections and Diagnostics
- Urological Disorders and Treatments
- HIV-related health complications and treatments
Instituto Nacional de Neurología y Neurocirugía
2015-2024
Universidad de San Martín de Porres
2022
Universidad Nacional Autónoma de México
2011
Cleveland Clinic
2003
The diagnosis of neurocysticercosis (NCC) remains problematic because the heterogeneity its clinical, immunological, and imaging characteristics. Our aim was to develop assess a new set diagnostic criteria for NCC, which might allow accurate detection of, differentiation between, parenchymal extraparenchymal disease.A group Latin American NCC experts developed by consensus NCC. A multicenter, retrospective study then conducted validate it. reference standard active disappearance or reduction...
Abstract Background Neurocysticercosis (NC) is one of the most frequent parasitic diseases central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in parenchyma. In contrast, lodged subarachnoid basal cisterns less responsive to treatment. Case Presentation The clinical radiological pictures six Mexican patients non-respondent cysticidal treatment presented. Conclusions possible factors involved non-response discussed hints...
Human neurocysticercosis (NC) is caused by Taenia solium larvae lodged in the central nervous system. Most cases occur with no, or mild, neurological symptoms. However, some patients, neuroinflammation exacerbated, leading to severe forms of disease. Considering critical role regulatory T cells (Tregs) balancing inflammation chronic diseases, their participation restraining inflammatory response NC was explored present study. The frequency Tregs and relationship level proliferative response,...
Neurocysticercosis is caused by the establishment of Taenia solium cysticerci in central nervous system. It considered that, during co-evolution, parasite developed strategies to modulate host's immune response. The action mechanisms regulatory T cells controlling response neurocysticercosis are studied this work. Higher blood levels with CD4(+) CD45RO(+) forkhead box protein 3 (FoxP3)(high) and CD25(high) FoxP3(+) CD95(high) phenotype non-regulatory FoxP3(med) were found patients respect...
Regulatory T cells (Tregs) play a crucial role in immune homeostasis. Treg induction is strategy that parasites have evolved to modulate the host’s inflammatory environment, facilitating their establishment and permanence. In human Taenia solium neurocysticercosis (NC), concurrence of increased peripheral central levels capacity inhibit cell activation proliferation support controlling neuroinflammation. This study aimed at identifing possible mechanisms NC. Monocyte-derived dendritic (DC)...
Tuberculosis (TB) remains an important public health problem in developing countries.To evaluate the clinical presentation, management, and long-term outcome 6 patients with tuberculous brain abscesses (TBA), uncommon form of central nervous system (CNS) TB.A search medical records a single referral neurological center Mexico City from 2002 to 2007 retrieved 149 CNS TB; them (4%) met Whitener's criteria for TBA were included this review.Five six had previous history TB. Three referred our...
We report a young patient with variant of juvenile idiopathic arthritis, who, after 4 years infliximab treatment, developed miliary tuberculosis (TB) central nervous system involvement (meningitis and multiple tuberculomas). After anti-TB clinical radiologic responses were observed, but severe cerebrospinal fluid brain inflammatory reaction, nonresponsive to corticosteroids, persisted. It was considered life-threatening paradoxical reaction based on initial isolation Mycobacterium fully...
Taeniids exhibit a great adaptive plasticity, which facilitates their establishment, growth, and reproduction in hostile inflammatory microenvironment. Transforming Growth Factor-β (TGFβ), highly pleiotropic cytokine, plays critical role vertebrate morphogenesis, cell differentiation, reproduction, immune suppression. TGFβ is secreted by host cells sites lodging parasites. The of the outcome T. solium crassiceps cysticercosis herein explored. Homologues family receptors (TsRI TsRII) several...
<b><i>Objective:</i></b> Parkinson’s disease (PD) patients are usually treated with L-dopa and/or dopaminergic agonists, which act by binding five types of receptors (DRD1–DRD5). Peripheral immune cells known to express dopamine on their membrane surface, and therefore they could be directly affected the treatment. Regulatory main modulators inflammation, but it is not clear whether treatment affect functions. While only regulatory T (Tregs) have been proved...
In disease-endemic areas, severe cysticercal meningitis (SCM) is characterized by intense inflammatory cerebrospinal fluid (CSF) and negative bacterial fungal cultures. There have been no systematic studies of SCM. We patients with SCM compare them neurocysticercosis (NC) mild CSF abnormalities conducting a nine-year retrospective review at neurological referral center. Two groups were compared: group A, those pleocytosis > 1,000 cells/mm(3) (n = 12), B, <or= 126). All had positive results...
Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well tachyphylaxis systemic, undesirable side effects main limitations peripheral delivery. Intranasal administration offers direct access brain it bypasses blood-brain barrier. The Mucosal Atomization Device is an optimal tool that can achieve rapid absorption into CNS bloodstream across mucosal...
The development and validation of an LC-MS/MS method for the simultaneous determination albendazole metabolites (albendazole sulfoxide sulfone) in human plasma are described. Samples 200 μL were extracted with ether-dichloromethane-chloroform (60:30:10, v/v/v). chromatographic separation was performed using a C(18) column methanol-formic acid 20 mmol/L (70:30) as mobile phase. linear range 20-5000 ng/mL 10-1500 sulfone. For both analytes precise (RSD < 12%) accurate (RE <7%) high recovery...