A5018224422- Parasitic infections in humans and animals
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Genomics, phytochemicals, and oxidative stress
- Parasite Biology and Host Interactions
- Drug Solubulity and Delivery Systems
- Helminth infection and control
- Congenital Anomalies and Fetal Surgery
- Advanced Drug Delivery Systems
- Amoebic Infections and Treatments
- Dermatological and Skeletal Disorders
- Systemic Lupus Erythematosus Research
- Synthesis and Biological Evaluation
- Inflammatory Myopathies and Dermatomyositis
- Remote Sensing in Agriculture
- Heme Oxygenase-1 and Carbon Monoxide
- Remote Sensing and LiDAR Applications
- Moringa oleifera research and applications
- Vascular Malformations Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Trigeminal Neuralgia and Treatments
- Drug-Induced Adverse Reactions
- Polyomavirus and related diseases
- Antibiotics Pharmacokinetics and Efficacy
Instituto Nacional de Neurología y Neurocirugía
2013-2023
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
Universidad Nacional Autónoma de México
2008-2016
Universidad Autónoma de Zacatecas "Francisco García Salinas"
2005
Abstract Extraparenchymal neurocysticercosis is the most severe form of cysticercosis, and response to treatment suboptimal. We sought determine how demographic clinical characteristics albendazole sulfoxide concentrations were related cysticidal response. conducted a longitudinal study 31 participants with extraparenchymal vesicular parasites who received same treatment, 30 mg/kg/day for 10 days dexamethasone 0.4 13 days, followed by prednisone taper. Response was determined parasite...
The development and validation of an LC-MS/MS method for the simultaneous determination albendazole metabolites (albendazole sulfoxide sulfone) in human plasma are described. Samples 200 μL were extracted with ether-dichloromethane-chloroform (60:30:10, v/v/v). chromatographic separation was performed using a C(18) column methanol-formic acid 20 mmol/L (70:30) as mobile phase. linear range 20-5000 ng/mL 10-1500 sulfone. For both analytes precise (RSD < 12%) accurate (RE <7%) high recovery...
Giardia duodenalis causes giardiasis, a major diarrheal disease in humans worldwide whose treatment relies mainly on metronidazole (MTZ) and albendazole (ABZ). The emergence of ABZ resistance this parasite has prompted studies to elucidate the molecular mechanisms underlying phenomenon. G . trophozoites convert into its sulfoxide (ABZSO) sulfone (ABZSOO) forms, despite lacking canonical enzymes involved these processes, such as cytochrome P450s (CYP450s) flavin-containing monooxygenases...
Hydroxychloroquine has been proposed for HIV treatment; however, little is known about its disposition in the lymphatic system, where replication takes place. Therefore, distribution lymphoid tissues (Peyer's patches and popliteal, submandibular, femoral, splenic, prescapular lymph nodes) was evaluated compared with that blood. Results showed a high affinity of hydroxychloroquine all these tissues, higher splenic submandibular nodes, suggesting potential use as coadjuvant therapy.
Background Adherence to disease-modifying therapies is determinant attain maximal clinical benefit in multiple sclerosis (MS). RebiSmart® an electronic auto-injector for subcutaneous delivery of interferon β-1a (INF-β1a) that monitors adherence by featuring a log each drug administration objective evaluation. The aim this study was assess long-term INF-β1a using the device Mexican patients with relapsing MS. Methods This observational multicenter on MS treated subcutaneously delivered...
ABSTRACT Scleroderma is an autoimmune disease characterized by early inflammatory infiltrates followed fibrosis in the skin and internal organs. CREST a relatively benign cutaneous variant of scleroderma that features calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly telangiectases. Glomerulonephritis rare association CREST. We are reporting patient with who developed glomerulonephritis had anticentromere antineutrophil cytoplasmic autoantibodies (ANCA) her serum.
Purpose: To determine the pharmacokinetics of cefuroxime axetil in malnourished rats using a diet with restriction energy and nutrients (group M), low quality protein K) good C) as control. Methods. The were fed corresponding during 21 days. After this period single oral dose (equivalent to 2.2 mg cefuroxime) was administered, plasma samples taken at 0, 5, 10, 30, 45, 60, 90, 120, 180, 240, 300 360 minutes; assayed an HPLC assay. Biochemical parameters also measured microscopy study small...
Background: Although albendazole is the drug-of-choice for treatment of neurocysticercosis, its efficacy limited due to low bioavailability. An alternative optimizing pharmacological through drug combinations. In vitro studies have shown that nitazoxanide and tizoxanide (the active metabolite nitazoxanide) exhibit cysticidal activity combination with sulfoxide albendazole) produced an additive effect. Objectives: (1) To assess concentration profile in plasma cerebrospinal fluid; (2) evaluate...
βCD dendritic derivatives are stable and suitable nanocarriers to enhance ABZ potency by improving solubility permeation.
Based on our previous research cysticidal drugs, we report the synthesis and evaluation of three new benzimidazole derivatives. In these compounds, amido group was used as a bioisosteric replacement ester group. The molecular docking β-tubulin revealed that derivatives interacted through hydrogen bonding with N165, E198 V236. All compounds showed in vitro activity against Taenia crassiceps cysts. Among them, 3 found to be most potent series (EC50 0.86 µM). This compound also exhibited...
In this paper we present forest cover change analysis by object based method with SPOT-5 (2007) and RapidEye (2013) images for an Ejido in the state of Jalisco, Mexico. We identified three classes each date: 1) 2) degraded 3) non-forest. An image was applied to first segment into objects, then classify objects above classes. compared results from model a on pixel method. Classified both methods were evaluated verification data composed 254 random points obtained slightly higher overall...
Albendazole is a broad-spectrum anthelmintic drug used for parasitic infections. In addition, due to its mechanism of action, it has been studied as an anticancer agent. However, poor and highly variable bioavailability are limiting factors use in systemic illnesses. The present study aimed develop two parenteral formulations albendazole compare pharmacokinetic profile with the conventional oral administration. Parenteral were developed using different approaches: phosphonooxymethylated...
Albendazole is an anthelmintic drug commonly used in parenchymal neurocysticercosis and cystic echinococcosis. The aim of this study was to explore whether disparities the dissolution profiles albendazole products lead significant differences pharmacokinetic parameters. Three generic innovator were evaluated vitro. Quality control tests performed, obtained according Mexican Pharmacopeia. Although all passed quality tests, none complied with similarity factor (f 2). product lowest f 2 value...