A5022153042- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Estrogen and related hormone effects
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Plant Disease Resistance and Genetics
- Acute Myocardial Infarction Research
- Hormonal and reproductive studies
- Wheat and Barley Genetics and Pathology
- Cardiac Ischemia and Reperfusion
- Plant tissue culture and regeneration
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Platelet Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metal complexes synthesis and properties
- Atrial Fibrillation Management and Outcomes
- Folate and B Vitamins Research
- Chromosomal and Genetic Variations
- Cardiovascular Function and Risk Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetic Associations and Epidemiology
- Menopause: Health Impacts and Treatments
Instituto Nacional de Cardiología
2012-2025
Universidad Nacional Autónoma de México
2014-2025
Secretaría de Salud de Bogotá
2024
Instituto Nacional de Cardiologia
2003-2022
Sociedad Española de Trombosis y Hemostasia
2021
Google (United States)
2020
Baylor College of Medicine
2020
Clinica Universidad de Navarra
2017
Hospital Universitario La Paz
2009
Universidad Complutense de Madrid
1984-2008
Background. Mutations in the TRPC6 gene have been reported six families with adult-onset (17–57 years) autosomal dominant focal segmental glomerulosclerosis (FSGS). Electrophysiology studies confirmed augmented calcium influx only three of these mutations. To date, role childhood and adulthood non-familial forms is unknown. Methods.TRPC6 mutation analysis was performed by direct sequencing 130 Spanish patients from 115 unrelated FSGS. An silico scoring matrix developed to evaluate...
Background. The molecular mechanisms underlying acute coronary syndrome (ACS) have been extensively investigated, with a particular focus on the role of circulating microvesicles (MVs) as carriers regulatory elements that influence hemodynamic changes and flow. Endothelial platelet dysfunction during ACS alters MV composition, impacting clinical outcomes. This study explores levels miR-126-5p miR-223-3p in MVs their association Thrombolysis Myocardial Infarction (TIMI) flow classification...
Platelets play a pivotal role in physiological hemostasis. However, coronary arteries damaged by atherosclerosis, enhanced platelet aggregation, with subsequent thrombus formation, is precipitating factor acute ischemic events. Avocado pulp (Persea americana) good source of bioactive compounds, and its inclusion the diet as fatty acid has been related to reduced aggregability. Nevertheless, constituents avocado antiplatelet activity remain unknown. The present study aims characterize...
Although 4% of cerebral infarcts in the young can be attributed to hematologic disturbances that predispose thrombosis, frequency caused by prothrombotic states is not known. Recently, association between infarction and deficiencies elements natural anticoagulant system has been recognized. Thirty-six consecutive patients under 40 years age with undetermined cause were prospectively studied. Quantitation anticoagulants was done at least 3 months after infarction. The following activity tests...
Aim: Was to evaluate the role of seven matrix metalloproteinase (MMP) polymorphisms in genetic susceptibility develop myocardial infarction Mexican individuals.Methods: Seven MMP genes were genotyped by 5' exonuclease TaqMan genotyping assays 300 patients with and healthy unrelated controls.Results: A similar distribution MMP2-1306 (rs243865), MMP2-790 (rs243864), MMP2-735 (rs22850553), MMP7-153(rs11568819), MMP7-181(rs11568818), MMP12-82(rs2276109) was observed both studied groups. On other...
Background: Lipoprotein (Lp(a)) and homocysteine (Hcy) are independent risk factors for coronary artery disease (CAD). Hcy promotes the release of free apo(a) from Lp(a). The high fibrin affinity inhibits plasminogen binding plasmin generation. Hyperhomocysteinemia can result a less active variant methylene tetrahydrofolate reductase (variant C677T). Because C677T genotype is estimated to be present in 32.2% Mexican population, we took advantage this prevalence determine possible...
Summary Hispano‐Breton (HB) is a horse breed with recent mixed ancestry. It was developed in the 1930s by crossing local mares Breton draught horses imported from France. Nowadays it considered to be vulnerable situation due census decline. To genetically characterize and set up basis for conservation programme, we have employed two types of molecular markers: 347‐bp D‐loop mitochondrial DNA (mtDNA) fragment 13 microsatellite loci. A representative sample 53 HB individuals analysed together...
HLA class I and II alleles have been studied in 60 unrelated people belonging to Mayos ethnic group, which lives the Mexican Pacific Sinaloa State. profile was compared other Amerindians worldwide populations' profile. A total of 14,896 chromosomes were used for comparisons. Genetic distances between populations, Neigbour-Joining dendrograms correspondence analyses performed determine genetic relationship among population. The new specific Mayo haplotypes found are:...
Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (TMPRSS2) and serpine family E member 1 (SERPINE1) could help to elucidate the contribution variability COVID-19 outcomes. To evaluate genetic variants genes previously associated with outcomes, we performed cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. TMPRSS2 (rs2070788, rs75603675, rs12329760) SERPINE1 (rs2227631, rs2227667,...