A5047781276- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Fatty Acid Research and Health
- Virus-based gene therapy research
- ATP Synthase and ATPases Research
- Viral Infectious Diseases and Gene Expression in Insects
- Pulmonary Hypertension Research and Treatments
- Traditional and Medicinal Uses of Annonaceae
- Diet, Metabolism, and Disease
- Aortic aneurysm repair treatments
- Electron Spin Resonance Studies
- Cardiac electrophysiology and arrhythmias
- Transplantation: Methods and Outcomes
- Cannabis and Cannabinoid Research
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer Research and Treatments
- Cardiovascular and exercise physiology
- Autophagy in Disease and Therapy
- Plant biochemistry and biosynthesis
- RNA regulation and disease
- Lipoproteins and Cardiovascular Health
- Sarcoma Diagnosis and Treatment
Tecnológico de Monterrey
2013-2024
Hospital Zambrano Hellion
2014-2022
Medicina
2014
Universidad Autónoma de Nuevo León
2007
The role of the mitochondrial calcium uniporter (MCU) in energy dysfunction and hypertrophy heart failure (HF) remains unknown. In angiotensin II (ANGII)–induced hypertrophic cardiac cells we have shown that overexpress MCU present bioenergetic dysfunction. However, by silencing MCU, cell are prevented blocking overload, increase reactive oxygen species, activation nuclear factor kappa B–dependent proinflammatory signaling. Moreover, identified a calcium/calmodulin–independent protein kinase...
Stress-induced cardiomyopathy, triggered by acute catecholamine discharge, is a syndrome characterized transient, apical ballooning linked to heart failure and ventricular arrhythmias. Rats receiving an isoproterenol (ISO) overdose (OV) suffer cardiac apex ischemia-reperfusion damage arrhythmia, then undergo remodeling dysfunction. Nevertheless, the subcellular mechanisms underlying dysfunction after subsides are not thoroughly understood. To address this question, Wistar rats received...
The effective delivery of antioxidants to the cells is hindered by their high metabolization rate. In this work, quercetin was encapsulated in poly(lactic-co-glycolic) acid (PLGA) nanoparticles. They were characterized terms its physicochemical properties (particle size distribution, ζ -potential, encapsulation efficiency, release and biological interactions with cardiac regarding nanoparticle association, internalization protective capability against relevant challenges). A better achieved...
Cyclophilin D (CypD) mediates the mitochondrial permeability transition pore (mPTP) opening that contributes to dysfunction. CypD is regulated by its acetylation/deacetylation state depends on Sirtuin-3 (SIRT3) deacetylase. Since obesity and metabolic syndrome decrease SIRT3 activity expression, we tested hypothesis hyperacetylation promotes dysfunction under this pathophysiological state, which associated with ventricular heart failure.Myocardial tissue samples from patients left failure,...
Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related abnormal calcium handling and energetic failure cardiomyocytes. Moreover, precise mechanisms underlying this debacle remain unclear. In order elucidate these mechanisms, article explores ex vivo function mitochondria after exposure nanoSiO2.The cumulative...
Platelets play a pivotal role in physiological hemostasis. However, coronary arteries damaged by atherosclerosis, enhanced platelet aggregation, with subsequent thrombus formation, is precipitating factor acute ischemic events. Avocado pulp (Persea americana) good source of bioactive compounds, and its inclusion the diet as fatty acid has been related to reduced aggregability. Nevertheless, constituents avocado antiplatelet activity remain unknown. The present study aims characterize...
Proinflammatory cytokines and the novel myokine irisin, a cleavage product of FNDC5, have been found to play role in obesity type 2 diabetes mellitus (T2DM). Irisin has shown increase browning adipose tissue, thermogenesis, energy expenditure, insulin sensitivity, yet its association with inflammatory markers is still limited. Circulating irisin be increased obesity, while adult subjects T2DM decreased levels found. However, data establishing circulating children adolescents not described...
The prevalence of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) has increased in the pediatric population. Irisin, an adipomyokine, is involved white adipose tissue browning, energy expenditure, insulin sensitivity, anti-inflammatory pathways. Data on associations among circulating irisin levels, soluble cell adhesion molecules (sCAMs), inflammatory cytokines scarce children adolescents with MetS T2DM. Subjects aged 6-16 years were grouped into T2DM, MetS, healthy controls....
The correlations between irisin levels, physical activity, and anthropometric measurements have been extensively described in adults with considerable controversy, but little evidence about these relationships has found children. objective of this study is to correlate the plasma levels underweight, normal weight, overweight, obese children parameters activity levels. A cross-sample 40 was divided into following groups on basis body mass index (BMI) percentile. anthropometric, metabolic were...
Adipokines and the myokine irisin, involved in mechanisms associated with obesity metabolic syndrome (MS), are understudied pediatric population.To investigate relationship between leptin, resistin, adiponectin, adipsin, anthropometric cardiovascular risk factors Mexican children.A cross-sample of 126 children aged 6-12 years old were classified as normal weight (n = 46), obese 40), MS 40) according to CDC's Cook's age-modified criteria for MS. Anthropometric parameters blood pressure...
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vessel remodeling; however, its severity and impact on survival depend right ventricular (RV) failure. Resveratrol (RES), a polyphenol found in red wine, exhibits cardioprotective effects RV dysfunction PAH. However, most literature has focused RES protective effect lung vasculature; recent finding indicates that independent of pressure dysfunction, although the underlying mechanism not been determined. Therefore, this study...
Metabolic syndrome (MS) increases cardiovascular risk and is associated with cardiac dysfunction arrhythmias, although the precise mechanisms are still under study. Chronic inflammation in MS has emerged as a possible cause of adverse events. Male Wistar rats fed 30% sucrose drinking water standard chow for 25–27 weeks were compared to control group. The group showed increased weight, visceral fat, blood pressure, serum triglycerides. most important cytokines included IL‐1 β (7‐fold), TNF‐ α...
Despite the importance of mitochondrial Ca(2+) to metabolic regulation and cell physiology, little is known about mechanisms that regulate entry into mitochondria. Accordingly, we established a system determine role uniporter in an isolated heart model, at baseline during increased workload following β-adrenoceptor stimulation.Cardiac contractility, oxygen consumption intracellular transients were measured ex vivo perfused murine hearts. Ru360 spermine used modify activity. Changes content...
Casiopeinas are a group of copper-based antineoplastic molecules designed as less toxic and more therapeutic alternative to cisplatin or Doxorubicin; however, there is scarce evidence about their effects on the whole heart cardiomyocytes. Given this, rat hearts were perfused with Doxorubicin mechanical performance, energetics, mitochondrial function measured. As well, Casiopeinas-triggered cell death explored in isolated III-Ea, II-gly, III-ia induced progressive sustained inhibition...
Background: Thyroid hormone status in hypothyroidism (HT) downregulates key elements Ca2+ handling within the heart, reducing contractility, impairing basal energetic balance, and increasing risk of cardiovascular disease. Mitochondrial transport is reduced HT, tolerance to reperfusion damage has been documented, but precise mechanism not well understood. Therefore, we aimed determine stoichiometry activity mitochondrial uniporter or uniplex an HT model relevance opening permeability...
Abstract Background Several human epithelial neoplasms are associated with high‐risk strains of papillomavirus (HPV) such as cervical, anorectal, and other carcinomas. For some tumor types the current therapeutic tools only palliative. Conditionally replicative adenoviruses (CRAds) promising antineoplastic agents, which also can trigger confined antitumor effects. Methods We constructed a series CRAds driven by upstream regulatory promoter region (URR) an Asian‐American variant HPV‐16,...
Hypertension, central obesity, hyperglycemia, and dyslipidemia are key risk factors for cardiovascular disease. However, the specific contributing to development of unfavorable cardiometabolic characteristics in children with obesity unknown. In this study, we investigated cross-sectional relationships between cytokines, irisin, fatty acid (FA) composition plasma school-age metabolically healthy unhealthy (MHO MUO, respectively) same age body mass index waist circumference percentiles. We...