A5036923659- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Mesoporous Materials and Catalysis
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Polyoxometalates: Synthesis and Applications
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Aerogels and thermal insulation
- Meningioma and schwannoma management
- Salivary Gland Disorders and Functions
- Sepsis Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Metabolism and Genetic Disorders
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal and reproductive studies
- Ocular Surface and Contact Lens
- Mitochondrial Function and Pathology
- E-Learning and Knowledge Management
- Glaucoma and retinal disorders
- Layered Double Hydroxides Synthesis and Applications
- Glioma Diagnosis and Treatment
- Gut microbiota and health
Universitat de València
2015-2025
INCLIVA Health Research Institute
2014-2025
Hospital Universitario Virgen del Rocío
2022-2023
Hospital Research Foundation
2016-2022
Universidad de Los Andes
2022
Tecnológico de Monterrey
2017
Hospital Clínico Universitario de Valencia
2008-2016
Instituto de Agroquímica y Tecnología de Alimentos
2016
Hospital Universitario Río Hortega
2016
Federal Ministry of Labour and Social Affairs
2002-2008
The existing knowledge about the health-related quality of life (HRQoL) and its relationship to cognitive and/or emotional functioning in multiple sclerosis (MS) is scarce. We assessed differences between subgroups MS outpatients (n = 209) on one HRQoL instrument: a version Functional Assessment Multiple Sclerosis instrument; two tests: Mini-Mental State Examination clock drawing test; Hamilton Rating Scale for Depression Anxiety. Three disease-related characteristics were assessed: physical...
Abstract Colorectal cancer is the second leading cause of death in developed countries. There a need for better preventive strategies to improve outcome this disease. The increasing availability high‐throughput methodologies opens up new possibilities screening markers. application NMR metabolic profiling fecal water extracts has interesting potential as diagnostic tool detecting colorectal cancer. We obtained profiles from patients with and healthy individuals, characterize possible...
Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been associated with hepatotoxic effects and alterations lipid body fat composition. Given the importance of liver regulation, we have evaluated clinically concentrations EFV on mitochondria metabolism hepatic cells vitro . Mitochondrial function was rapidly undermined by to an extent that varied concentration employed; particular,...
The composition of human breast milk is highly variable, and it can be influenced by genetics, diet, lifestyle, other environmental factors. This study aimed to investigate the impact geographical location mode delivery on nuclear magnetic resonance spectroscopy (NMR) metabolic profile its relationship with microbiome. Human microbiota profiles were determined using NMR 16S rRNA gene sequencing, respectively, in 79 healthy women from Finland, Spain, South Africa, China. Up 68 metabolites,...
Abstract Background Low birth weight has been linked to an increased risk develop obesity, type 2 diabetes, and hypertension in adult life, although the mechanisms underlying association are not well understood. The objective was determine whether metabolomic profile of plasma from umbilical cord differs between low normal newborns. Methods Fifty healthy pregnant women their infants were selected. eligibility criteria being born at term having a pregnancy. Pairs grouped according weight:...
Early diagnosis and patient stratification may improve sepsis outcome by a timely start of the proper specific treatment. We aimed to identify metabolomic biomarkers in urine 1H-NMR spectroscopy assess severity predict outcomes. Urine samples were collected from 64 patients with severe or septic shock ICU for 1H NMR spectra acquisition. A supervised analysis was performed on processed spectra, predictive model prognosis (30-days mortality/survival) constructed using partial least-squares...
Oxidative stress forms part of the molecular basis contributing to development and manifestation myopia, a refractive error with associated pathology that is increasingly prevalent worldwide subsequently leads an upsurge in degenerative visual impairment due conditions are especially high myopia. The purpose our study was examine interrelation potential oxidative-stress-related metabolites found aqueous humor high-myopic, low-myopic, non-myopic patients within clinical study. We conducted...
Metabolic-dysfunction-associated steatotic liver disease (MASLD) affects around 30% of the global population. The sexual dimorphism and gut microbiota play an important role in early development MASLD. main objective this research was to investigate metabolic changes during subclinical MASLD progression, for identifying sequence events evaluating impact on initial stages development. Male female Wistar rats 18 weeks old were randomly divided into different groups fed a chow diet or 45%...
Nanoparticulated bimodal porous silicas (NBSs) with pore systems structured at two length scales (meso- and large-meso-/macropores) have been prepared through a one-pot surfactant-assisted procedure by using simple template agent starting from silicon atrane complexes as hydrolytic inorganic precursors. The final bulk materials are constructed an aggregation of pseudospherical mesoporous primary nanoparticles process, over the course which interparticle (textural) large system is generated....
Meningiomas are neoplasms that arise from the leptomeningeal covering of brain and spinal cord, accounting for 15%−20% CNS tumors. The WHO classifies meningiomas into three histological grades: benign, atypical, anaplasic in accordance with clinical prognosis. Atypical tend to recur. Sometimes, diagnosis benign meningioma show characteristics atypical meningioma. In this context, high-resolution magic-angle spinning (HR-MAS) spectroscopy intact tissue tumor biopsies has shown great potential...
Exercise has been associated with several beneficial effects and is one of the major modulators metabolism. The working muscle produces releases substances during exercise that mediate adaptation but also improve metabolic flexibility complete organism, leading to adjustable substrate utilization. Metabolomic studies on physical are scarce most them have focused intense in professional sportsmen. aim our study was determine plasma metabolomic adaptations mice after a long-term spontaneous...
We used (1)H NMR spectroscopy to analyze the metabolomic profile of reflex tears from patients with dry eye disorders (DEDs). 90 subjects were divided into 2 groups: (1) DEDs (DEDG; n = 55) and (2) healthy (CG; 35). Additionally, DEDG was subdivided subgroups based on DED severity: mild-to-moderate moderate (n 22 33, resp.). Personal interviews systematized ophthalmologic examinations carried out. Reflex (20-30 μL) collected by gently rubbing in inferior meniscus both eyelids a microglass...
In 1994–1995, a screening and examination survey was conducted to ascertain the prevalence of dementia, Parkinson’s disease stroke in two urban communities one rural community central Spain. We use this illustrate many nonclinical aspects conducting two-phase surveys. Special emphasis is given common weaknesses such surveys: nonparticipation validation.
Metabolic syndrome (MetS) has become one of the main concerns for public health because its link to cardiovascular disease. Murine models have been used study effect MetS on system, but they limitations studying cardiac electrophysiology. In contrast, rabbit electrophysiology is similar human, a detailed characterization different components in this animal still needed. Our objective was develop and characterize diet-induced experimental model that allows remodeling arrhythmogenesis. Male...
Cognitive dysfunction is a major handicap in multiple sclerosis (MS). Its prevalence varies due to disease heterogeneity and methodological issues. A neuropsychological battery of intermediate size was designed for explored the screening cognitive MS patients.The administered hospital-based sample 191 patients 50 matched controls. Eleven test scores measuring verbal fluency, learning, attention, calculation visuoperceptual ability were selected on basis sensitivity lack redundancy. Two...
Around 20% of meningiomas histologically benign may be clinically aggressive and recur. This strongly affects management meningioma patients. There is a need to evaluate the potential aggressiveness an individual meningioma. Additional criteria for better classification will improve clinical decisions as well patient follow up strategy after surgery. The aim this study was determine relationship between gene expression profiles new metabolic subgroups with relevance. Forty fourteen atypical...
To identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred two subjects, Caucasian, more than 18 years, representative of population, were included. Blood pressure measurement albumin/creatinine ratio measured in urine sample. Using SNPlex, 1251 SNPs potentially associated urinary albumin excretion (UAE) analyzed. Serum profile was assessed by 1H NMR spectra Brucker Advance DRX...
Bone pathologies such as osteoporosis (OTP) and osteoarthritis (OA) are rising in incidence with the worldwide rise life expectancy. The diagnosis is usually obtained using imaging techniques densitometry, but both being multifactorial diseases, several molecular mechanisms remain to be understood. Metabolomics offers potential detect global changes which can lead identification of biomarkers a better insight progress diseases. Our aim was compare metabolic profiles cohort 100 postmenopausal...
The extracellular matrix (ECM) has an important role in the development and maintenance of skeletal muscle, several muscle diseases are associated with dysfunction ECM elements. MAMDC2 is a putative protein its cell proliferation been investigated certain cancer types. However, participation physiology not previously studied. We describe 17 individuals autosomal dominant muscular dystrophy belonging to two unrelated families which different heterozygous truncating variants last exon...