A5016593302- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Vitamin D Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Complement system in diseases
- Organophosphorus compounds synthesis
- Escherichia coli research studies
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Iron Metabolism and Disorders
- Synthesis and Reactions of Organic Compounds
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Phosphorus compounds and reactions
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Enzyme Catalysis and Immobilization
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Bioactive Compounds and Antitumor Agents
South Tees Hospitals NHS Foundation Trust
2017-2024
James Cook University Hospital
2024
Louisiana State University
2007-2020
Birmingham Children's Hospital
2002-2013
Edinburgh Napier University
2011
University of Birmingham
2009
GlaxoSmithKline (United Kingdom)
2006-2009
Massey University
2001-2007
University of Pennsylvania
1994-2003
University of Auckland
1989-2003
Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling of p -nitrophenyl esters N -acetyl valine, leucine, and phenylalanine tryptophan amide to form corresponding dipeptides. All possible stereoisomeric combinations ester substrates were coupled at comparable rates. The antibodies did not catalyze hydrolysis dipeptide product nor or racemization activated esters. yields dipeptides ranged from 44 94 percent. capable multiple turnovers rates that exceeded...
In a three year study of children under 16 years with haemolytic uraemic syndrome faecal samples were examined for the presence Verocytotoxin producing Escherichia coli (VTEC) using DNA probes and free neutralisable in Vero cell assay specific antisera. There was evidence VTEC infection 58 185 (31%) samples. A total 53 identified from patients syndrome. Thirty eight belonged to serotype O157:H7 or O157:H-, 34 produced VT2 only, four strains both VT1 VT2. The remaining 15 nine different O...
In the nonobese diabetic (NOD) mouse, lymphocytic and monocytic infiltration of pancreatic islets leads to beta cell destruction. To investigate mechanisms by which lymphocytes enter NOD pancreas, pancreata were immunostained using monoclonal antibodies a variety adhesion molecules known be involved in lymphocyte binding vascular endothelium, an initial step migration from blood into organized lymphoid inflamed tissues. These include: homing receptors tissue-selective peripheral lymph node...
The G protein-coupled receptors, GPR41 and GPR43, are activated by short-chain fatty acids (SCFAs), with distinct rank order potencies. This study investigated the possibility that SCFAs modulate intestinal motility via these receptors. Luminal SCFA concentrations within rat intestine were greatest in caecum (c. 115 mmol L(-1)) proximal colon. Using similar (0.1-100 L(-1)), found to inhibit electrically evoked, neuronally mediated contractions of distal colon, possibly a prejunctional site...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective Synthesis of Diverse .alpha.-Amino Phosphonate DiestersAmos B. Smith III, Kraig M. Yager, and Carol TaylorCite this: J. Am. Chem. Soc. 1995, 117, 44, 10879–10888Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00149a011https://doi.org/10.1021/ja00149a011research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlycosylation on the Merrifield Resin Using Anomeric SulfoxidesLin Yan, Carol M. Taylor, Robert Goodnow Jr., and Daniel KahneCite this: J. Am. Chem. Soc. 1994, 116, 15, 6953–6954Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00094a067https://doi.org/10.1021/ja00094a067research-articleACS PublicationsRequest reuse permissionsArticle...
1. The metabolism of an intravenous pulse dose double-isotope-labelled cholecalciferol has been studied in control subjects with widely differing states vitamin D nutrition and patients primary disorders parathyroid function. 2. formation labelled 1,25-dihydroxy-cholecalciferol [1,25-(OH)2D3] 24,25-dihydroxycholecalciferol [24,25-(OH)2D3] related to the prevailing concentrations serum 25-hydroxycholecalciferol [25-(OH)D3], immunoreactive hormonel, calcium orthophosphate (Pi). 3. In relative...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric Synthesis of .alpha.-Aminophosphonates via Diastereoselective Addition Lithium Diethyl Phosphite to Chelating IminesKraig M. Yager, Carol Taylor, and Amos B. Smith IIICite this: J. Am. Chem. Soc. 1994, 116, 20, 9377–9378Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://doi.org/10.1021/ja00099a084RIGHTS & PERMISSIONSArticle Views673Altmetric-Citations88LEARN ABOUT...
A series of 37 girls with primary vesicoureteric reflux grade II and greater severity underwent urodynamic investigations. Twenty-eight (75%) were found to have unstable bladder activity. Disordered micturition patterns common persisted after urinary tract infections had been eradicated. Twenty-six urgency 19 urge incontinence occurring once per week or more. The correlation between these symptoms activity was significant (P less than 0.01), but there no instability the incidence renal scarring.
A series of phosphonochloridates was prepared from the corresponding phosphonate monoesters, and their reactions with alcohols, amines, bisnucleophile 4-aminobutan-1-ol have been investigated using 31P NMR spectroscopy. In conversion monoesters to via addition thionyl chloride or oxalyl chloride, pyrophosphonate anhydrides were found be formed readily as byproducts. The reacted but more slowly than phosphonochloridates, only sluggishly, if at all, amines. Therefore, when phosphonamides are...
Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration scalemic α-amino phosphonate 4.
The proinflammatory cytokines tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and IL-8 were measured in plasma urine samples from 19 children with verocytotoxin-producing<i>Escherichia coli</i> (VTEC) induced haemolytic uraemic syndrome (HUS) 30 controls. TNF-α was detected the of two cases one control; IL-6 one, cases, control. IL-1β each identified eight controls respectively. Urinary found seven four whom had concentrations below limit detection suggesting renal secretion...
NMR was used to study the thermodynamics of cis → trans isomerization for prolyl amide bonds in compounds shown. The magnitude Kt/c C-terminal esters is greater than corresponding amides, signifying stronger backbone stereoelectronic effects esters. Increasing steric bulk N-terminal residue from Ac- Ac-Gly- favors conformation. Incorporation a Phe Pro, however, shifts equilibrium favor conformation, via stabilizing aromatic−proline interaction.
A series of eight dipeptides the general formula Ac-Phe-Pro*-NHMe was synthesized and thermodynamics cis → trans isomerization about central amide bond were studied by NMR. Pro* represents following prolines: l-proline (Pro), l-trans-4-hydroxyproline (Hyp), l-cis-4-hydroxyproline (hyp), l-cis-4-methoxyproline (hyp[OMe]), l-trans-3-hydroxyproline (3-Hyp), l-cis-3-hydroxyproline (3-hyp), l-2,3-trans-3,4-cis-3,4-dihydroxyproline (DHP), l-2,3-cis-3,4-trans-3,4-dihydroxyproline (dhp). The...