A5029357603- RNA modifications and cancer
- MicroRNA in disease regulation
- Genetics, Aging, and Longevity in Model Organisms
- ATP Synthase and ATPases Research
- E-Learning and Knowledge Management
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- Educational Innovations and Technology
- Higher Education Teaching and Evaluation
- Neonatal and Maternal Infections
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- Bone Metabolism and Diseases
- Protein Degradation and Inhibitors
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Sepsis Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Educational Technology in Learning
Universitat de València
2015-2024
INCLIVA Health Research Institute
2011-2024
Centro de Investigación Biomédica en Red
2018-2023
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2022
Instituto de Salud Carlos III
2017-2022
Nu Skin (United States)
2018
Hospital Clínico Universitario de Valencia
2010-2017
Menéndez Pelayo International University
2017
Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation gene expression, we hypothesised that centenarians may reflect alterations RNA expression. We report first comparison microRNAs expression profiles mononuclear cells from centenarians, octogenarians young individuals resident near Valencia, Spain. Principal Component...
Abstract Sepsis is a life-threatening condition in preterm infants. Neonatal microbiota plays pivotal role the immune system maturation. Changes gut have been associated to inflammatory disorders; however, link with sepsis neonatal period has not yet established. We aimed analyze and mucosal gene expression using non-invasively obtained samples provide an integrative perspective of host-microbe interactions sepsis. For this purpose, prospective observational case-control study was conducted...
Aging | doi:10.18632/aging.101078. Consuelo Borras, Kheira M. Abdelaziz, Juan Gambini, Eva Serna, Marta Inglés, Monica de la Fuente, Idoia Garcia, Ander Matheu, Paula Sanchís, Angel Belenguer, Alessandra Errigo, Juan- Antonio Avellana, Ana Barettino, Carla Lloret-Fernández, Nuria Flames, Gianni Pes, Leocadio Rodriguez-Mañas, Jose Viña
BACKGROUND: Bacterial sepsis is associated with high morbidity and mortality in preterm infants. However, diagnosis of identification the causative agent remains challenging. Our aim was to determine genome-wide expression profiles very low birth weight (VLBW) infants without bacterial assess differences. METHODS: This a prospective observational double-cohort study conducted VLBW (<1500 g) culture-positive non-septic matched controls. Blood samples were collected as soon clinical...
Neonates are at increased risk for developing sepsis, but this population often exhibits ambiguous clinical signs that complicate the diagnosis of infection. No biomarker has yet shown enough diagnostic accuracy to rule out sepsis time suspicion. We show a gene-expression–based signature is an accurate objective measure in neonate or preterm infant, and it substantially improves over commonly used laboratory-based testing. Implementation might decrease inappropriate antibiotic use. Neonatal...
We have recently shown that mitochondrial fission is induced early in reprogramming a Drp1-dependent manner; however, the identity of factors controlling Drp1 recruitment to mitochondria was unexplored. To investigate this, we used panel RNAi targeting involved regulation dynamics and observed MiD51, Gdap1 and, lesser extent, Mff were found play key roles this process. Cells derived from Gdap1-null mice further explore role factor cell reprogramming. Microarray data revealed prominent...
Chemotherapy treatment is the standard in triple negative breast cancers, a cancer subgroup which lacks specific target. The mechanisms leading to response, as well any markers that allow differentiation between responder and non-responder groups prior are unknown. In parallel, miRNAs can act oncogenes or tumor suppressors there evidence of their involvement promoting resistance anticancer drugs. Therefore we hypothesized changes miRNA expression after doxorubicin may also be relevant...
The current knowledge regarding transcriptomic changes induced by alkalinity on plants is scarce and limited to studies where were subjected the alkaline salt for periods not longer than 48 h, so there no information available regulation of genes involved in generation a new homeostatic cellular condition after long-term stress. Lotus japonicus model legume broadly used study many important physiological processes including biotic interactions abiotic stresses. In present study, we...
Around 20% of meningiomas histologically benign may be clinically aggressive and recur. This strongly affects management meningioma patients. There is a need to evaluate the potential aggressiveness an individual meningioma. Additional criteria for better classification will improve clinical decisions as well patient follow up strategy after surgery. The aim this study was determine relationship between gene expression profiles new metabolic subgroups with relevance. Forty fourteen atypical...
Lotus japonicus is a model legume broadly used to study many important processes as nitrogen fixing nodule formation and adaptation salt stress. However, no studies on the defense responses occurring in this species against invading microorganisms have been carried out at present. Understanding how plant protects itself pathogens will certainly help develop more tolerant cultivars economically well other legumes. In order uncover most mechanisms activated upon bacterial attack, we explored...
Abstract KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for regulation stemness glioblastoma (GBM), which characterized by heterogeneous tumor stem–like cells associated with therapy resistance and disease relapse. expression upregulated cancer cells, mainly at perivascular regions tumors. RNAi-mediated silencing GBM impairs their tumorigenic capacity...
Insulin resistance is one of the main characteristics metabolic syndrome (MetS) and cause development type II diabetes. The high prevalence this in recent decades has made it necessary to search for preventive therapeutic agents, ideally natural origin, with fewer side effects than conventional pharmacological treatments. Tea widely known its medicinal properties, including beneficial on weight management insulin resistance. aim study was analyze whether a standardized extract green black...
Aims.Bifidobacterium pseudocatenulatum CECT 7765 improves metabolic and immunological altered functions in high fat fed mice, however little is known about the effects of potential probiotics on vascular reactivity.The aim present study was to investigate a probiotic strain, Bifidobacterium 7765, response obese mice.Methods.Aorta samples were obtained from which divided into three groups: control group, receiving standard diet; an high-fat group diet daily dose B. by oral gavage.Aortic rings...
Abstract Background Frailty is a major age‐associated syndrome leading to disability. Oxidative damage plays significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that highly dependent glucose 6‐P dehydrogenase (G6PD). G6PD‐overexpressing mouse (G6PD‐Tg) protected against metabolic stresses. Our aim was examine whether this protection delays Methods Old wild‐type (WT) and G6PD‐Tg mice were evaluated...
Extensive infiltration of the surrounding healthy brain tissue is a critical feature in glioblastoma. Several miRNAs have been related to gliomagenesis, some them with EGFR pathway. We evaluated whole-genome miRNA expression profiling associated different amplification patterns, studied by fluorescence situ hybridization microarrays, 30 cases primary glioblastoma multiforme, whose clinicopathological and immunohistochemical features also analyzed. MicroRNA-200c showed very significant...
During mammary gland involution, different signals are required for apoptosis and tissue remodelling. To explore the role of NO in involution after lactation, NOS2 (inducible nitric oxide synthase)-KO (knockout) mice were used. No apparent differences observed between NOS2-KO WT (wild-type) animals during pregnancy lactation. However, upon cessation a notable delay was observed, compared with mice. showed increased phosphorylation STAT (signal transducer activator transcription) 5 weaning,...
Pasteurized donor human milk (DHM) is the preferred alternative for infant nutrition when own mother's (OMM) unavailable. Whether DHM an efficient means protecting preterm infants from oxidative stress remains unknown. We quantified a panel of biomarkers in urine samples (≤32 weeks gestation and birth weight ≤1500 g) receiving ≥80% feeding volume as either or OMM. The noninvasive vivo assessment showed no statistically significant difference between both groups at time full enteral (150...
Cutaneous melanoma is an aggressive neoplasm and responsible for the majority of skin cancer deaths. Several miRNAs are involved in tumor progression. One them miR-205, loss which contributes to development metastasis. We evaluated whole-genome mRNA expression profiling associated with different miR-205 levels cells. Differential analysis identified 243 differentially expressed transcripts including inositol polyphosphate 5'-phosphatase-like protein-1 (INPPL1) BTB/POZ Domain-Containing...