A5043909598- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Cardiovascular and exercise physiology
- Non-Invasive Vital Sign Monitoring
- Cardiac Structural Anomalies and Repair
- ECG Monitoring and Analysis
- Pharmacological Effects and Toxicity Studies
- Signaling Pathways in Disease
- E-Learning and Knowledge Management
- Veterinary Pharmacology and Anesthesia
- Ion channel regulation and function
- Forensic Toxicology and Drug Analysis
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Knowledge Societies in the 21st Century
- Adipose Tissue and Metabolism
- Accounting and Financial Management
- Educational Technology in Learning
- Neuroscience and Neural Engineering
- Heart Failure Treatment and Management
- Opioid Use Disorder Treatment
- Diet and metabolism studies
- Cardiac pacing and defibrillation studies
INCLIVA Health Research Institute
2018-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2018-2025
Instituto de Salud Carlos III
2018-2025
Universitat de València
2018-2024
Centre for Biomedical Network Research on Rare Diseases
2024
Centro de Investigacion Principe Felipe
2017
Valencia Catholic University Saint Vincent Martyr
2013
Abstract Background Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure (HF). A paradoxical reduction its levels pathological conditions associated with acute processes been observed. We aimed to identify FAP cardiac tissue expression and relationship the main fibrosis-related signaling pathways, compare plasma chronic HF patients. Methods Transcriptomic changes were assessed via mRNA/ncRNA-seq left ventricle from patients (n = 57) controls 10). Western blotting...
Myocardial stretch is a proarrhythmic factor. Eleclazine (GS6615) late sodium current (INaL) inhibitor that has shown protective effects against arrhythmias in various experimental models. Data on its during myocardial are lacking. The aim of this study was to investigate the electrophysiological modifications induced by eleclazine basally and acute ventricular stretch. Left at baseline perfusion with 26 Langendorff rabbit heart preparations. Programmed stimulation high-resolution mapping...
BACKGROUND:Cardioplegic arrest is a common procedure for many types of cardiac surgery, and different formulations have been proposed to enhance its cardio-protective effect. Hydrogen sulfide an important signaling molecule that has properties. We therefore studied the effect hydrogen in cell culture potential therapeutic use combination with cardioplegia formulations. MATERIAL AND METHODS:We added donor GYY4137 HL-1 cells study protective nutrient starved conditions. In addition, we tested...
In recent years, obesity and metabolic syndrome (MetS) have become a growing problem for public health clinical practice, given their increased prevalence due to the rise of sedentary lifestyles unhealthy eating habits. Thanks animal models, basic research can investigate mechanisms underlying pathological processes such as MetS. Here, we describe methods used develop an experimental rabbit model diet-induced MetS its assessment. After period acclimation, animals are fed high-fat (10%...
Metabolic syndrome (MetS) has been linked to a higher prevalence of cardiac arrhythmias, the most frequent being atrial fibrillation, but mechanisms are not well understood. One possible underlying mechanism may be an abnormal modulation autonomic nervous system activity, which can quantified by analysing heart rate variability (HRV). Our aim was investigate modifications long-term HRV in experimental model diet-induced MetS identify early changes and link between dysregulation components....
A chronic model of acute myocardial infarction was developed to study the mechanisms involved in adverse postinfarction ventricular remodeling. In an (AMI), left circumflex coronary artery New Zealand White rabbits (n = 9) occluded by ligature for 1 h, followed reperfusion. specific care protocol applied before, during, and after intervention, results were compared with those a sham operated group 7). After 5 weeks, programmed stimulation high-resolution mapping performed on isolated...
Levamisole is an anthelmintic drug restricted to veterinary use but currently detected as the most widely used cocaine cutting agent in European countries. Levamisole-adulterated has been linked acute kidney injury, marked by a decrease glomerular filtration rate, which involves reduced renal blood flow, data on alteration of renovascular response produced levamisole are scarce. Renal arteries were isolated from healthy rabbits and for isometric tension recording organ baths protein...
Levamisole, a veterinary anthelmintic drug, is one of the most widely used and dangerous cocaine adulterants. Like cocaine, levamisole acutely blocks noradrenaline reuptake but with much less potency, although its vascular effects are not well known. In this study, we evaluated in rabbit aortic rings for isometric recording tension organ baths protein expression by western blot. Our results indicated that (10-5-10-3 M) induced concentration-dependent relaxation precontracted (10-7-3 × 10-7...
Abstract Background Mechanical stretch modifies Ca2+ handling and myocardial electrophysiology, favoring arrhythmogenesis. The store-overload-induced release (SOICR) through the ryanodine receptor (RyR2) seems to be implicated in this deleterious effect. Carvedilol its analogue VK-II-86 (which does not have significant beta-blocking effects) suppress SOCIR by directly reducing open duration of cardiac RyR2, could modulate calcium-related changes produced stretch. Purpose aim study was...
Abstract Background Metabolic syndrome (MetS) is becoming one of the future potential leading risk factors for heart and cardiovascular disease. MetS relates to a condition associated with at least three metabolic raising health diseases concomitantly such as diabetes, stroke, hypertension, obesity dyslipidemia. This can lead chest pain, attack, damage overall higher prevalence disease, atrial fibrillation sudden cardiac death. One underlying mechanisms progressive remodeling in presence...
Abstract Background Acute regional ventricular stretch (ARVS) is a pathophysiologic event that may occur in certain situations, originating arrhythmogenic effects through the mechanoelectrical feedback. Mechanical of originate calcium-related changes as sarcoplasmic recticulum Ca2+ overload can trigger diastolic leaks (store-overload-induced release, SOICR), mediated by cardiac ryanodine receptor (RyR2). SOICR seems to be implicated mechanisms underlying stretch-induced arrhythmias....
Abstract Introduction Ca2+/calmodulin-dependant protein kinase II (CaMKII) activity in cardiomyocytes plays a crucial role their contractility. Increased CaMKII signalling has been associated with mechanical stretch, often caused the border zone of myocardial infarction. upregulation causes mishandling intracellular calcium, precursor multiple pro-arrhythmic mechanisms, such as early afterdepolarisations. Purpose In this study, we aim to quantify effects KN-93 -a inhibitor- on wave dynamics,...
Abstract Introduction In myocardial infarction there are complications associated with adverse cardiac remodeling that occurs during the fibrotic process, producing an arrhythmogenic substrate favors triggering of ventricular arrhythmias such as fibrillation (VF). These also contribute to infarct expansion and mortality. Purpose To analyze, in a model chronic (5 weeks) rabbits, effects valproic acid (VA), inhibitor histone deacetylase enzymes, on inducibility size. Methods 47 New Zealand...