A5042312917- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Neurobiology and Insect Physiology Research
- Reproductive Biology and Fertility
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- DNA Repair Mechanisms
- GDF15 and Related Biomarkers
- Catalytic C–H Functionalization Methods
Instituto de Biomedicina de Valencia
2013-2025
University College London
2020-2024
Hospital Universitario de Getafe
2016
Universitat de València
2013
Transcription factors that drive neuron type-specific terminal differentiation programs in the developing nervous system are often expressed several distinct neuronal cell types, but to what extent they have similar or activities individual types is generally not well explored. We investigate this problem using, as a starting point, C. elegans LIM homeodomain transcription factor ttx-3, which acts selector program of cholinergic AIY interneuron class. Using panel different markers, including...
Cell differentiation is controlled by individual transcription factors (TFs) that together activate a selection of enhancers in specific cell types. How these combinations TFs identify and their target sequences remains poorly understood. Here, we the cis-regulatory transcriptional code controls serotonergic HSN neurons Caenorhabditis elegans. Activation transcriptome directly orchestrated collective six TFs. Binding site clusters for this TF form regulatory signature sufficient de novo...
Aging | doi:10.18632/aging.101078. Consuelo Borras, Kheira M. Abdelaziz, Juan Gambini, Eva Serna, Marta Inglés, Monica de la Fuente, Idoia Garcia, Ander Matheu, Paula Sanchís, Angel Belenguer, Alessandra Errigo, Juan- Antonio Avellana, Ana Barettino, Carla Lloret-Fernández, Nuria Flames, Gianni Pes, Leocadio Rodriguez-Mañas, Jose Viña
Summary How nervous systems coordinate the generation of specific neuron types with gene expression plasticity and how these mechanisms impact cell type evolution is unknown. Here we use Caenorhabditis species to study neuron-type robustness, evolution, using VC4 VC5 cholinergic motoneurons as models. In C. elegans , found that epigenetic silencing through histone 3 lysine 9 methylation (H3K9me) necessary suppress serotonin reuptake mod-5/ Sert a serotonergic phenotype in cells. contrast,...
Sexually dimorphic behaviours require underlying differences in the nervous system between males and females. The extent to which systems are sexually cellular molecular mechanisms that regulate these only beginning be understood. We reveal here a novel mechanism by male-specific neurons generated Caenorhabditis elegans through direct transdifferentiation of sex-shared glial cells. This glia-to-neuron cell fate switch occurs during male sexual maturation under cell-autonomous control...
Covalent immobilization of 4-hydroxybenzophenone on Merrifield resins affords new heterogeneous polymeric triplet photocatalysts. Their successful application in the intramolecular triplet-sensitized photolysis a α-diazo β-keto ester has been achieved under sustainable criteria. Remarkably, simple recovery and reuse for up to five sequential applications have performed, although resulting slightly decreasing activity.
We report that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for differential gene expression in cells produced by asymmetric cell divisions C. elegans. found elegans component, PSF-2 GINS2, necessary transcriptional upregulation of pro-apoptotic egl-1 BH3-only occurs programmed to die after they are through divisions. propose CMG's histone chaperone activity causes epigenetic changes at locus during replication mother cells, and these die. find also divergence other...