A5061416741- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Genetics, Aging, and Longevity in Model Organisms
- Cutaneous Melanoma Detection and Management
- RNA and protein synthesis mechanisms
- Amyotrophic Lateral Sclerosis Research
- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- RNA regulation and disease
- Drug-Induced Adverse Reactions
- Hair Growth and Disorders
- Autoimmune Bullous Skin Diseases
- Acne and Rosacea Treatments and Effects
- Herpesvirus Infections and Treatments
- Circadian rhythm and melatonin
- Forest Insect Ecology and Management
- Genetic and rare skin diseases.
- Insect Utilization and Effects
- Insect and Arachnid Ecology and Behavior
- Cancer-related gene regulation
- Cancer Diagnosis and Treatment
King's College London
2016-2022
Medical Research Council
2022
Howard Hughes Medical Institute
2015
Columbia University Irving Medical Center
2013-2015
St John's Hospital
2015
Vassar College
2008
Edinburgh Royal Infirmary
1995-2006
Royal Victoria Infirmary
1997-2003
Raigmore Hospital
2002
University of Edinburgh
1997
Transcription factors that drive neuron type-specific terminal differentiation programs in the developing nervous system are often expressed several distinct neuronal cell types, but to what extent they have similar or activities individual types is generally not well explored. We investigate this problem using, as a starting point, C. elegans LIM homeodomain transcription factor ttx-3, which acts selector program of cholinergic AIY interneuron class. Using panel different markers, including...
Recent progress revealed the complexity of RNA processing and its association to human disorders. Here, we unveil a new facet this complexity. Complete loss function ubiquitous splicing factor SFPQ affects zebrafish motoneuron differentiation cell autonomously. In addition nuclear localization, protein unexpectedly localizes motor axons. The cytosolic version abolishes axonal defects, rescuing key transcripts, restores motility in paralyzed sfpq null mutants, indicating non-nuclear role...
We report six cases of Dermatobia hominis myiasis imported into the U.K. from Belize. With increasing international travel, may be encountered more frequently in countries which parasites are not indigenous. The life-cycle D. is described, and scanning electron micrographs show detailed appearance larva.
Abstract Loss of SFPQ is a hallmark motor degeneration in ALS and prevents maturation neurons when occurring during embryogenesis. Here, we show that zebrafish, developing lacking exhibit axon extension, branching synaptogenesis defects, prior to degeneration. Subcellular transcriptomics reveals loss produces complex set aberrant intron-retaining (IR) transcripts coding for neuron-specific proteins accumulate neurites. Some these local IR mRNAs are prematurely terminated within the retained...
Forty-eight patients (23 male, 25 female) with severe alopecia areata were sensitized and treated topical diphencyprone. Thirty-eight per cent of the subjects had good regrowth hair at a mean follow-up period 30.8 months. The presence nail changes, personal history atopy long duration an adverse prognostic effect.
To many patients, the hospital doctor is epitomised by white coat. What patients think of way their dresses has generated considerable interest.1 2 Of further interest actual contents coat, and indeed senior doctors may be aware a “lightening” weight coat with concomitant increase in clinical responsibilities. This not phenomenon unique to obstetricians. The new house officer, weighed down essential items (tendon hammer, ophthalmoscope, handbook medical emergencies, etc) ensure …
We report a patient who developed symptoms of lupus erythematosus which was apparently related to minocycline therapy for acne vulgaris. To our knowledge, this is only the second reported case minocycline‐associated erythematosus.
Little population-based data has been published about skin cancers in children and young adults. In this study, 200 cases of melanoma non-melanoma diagnosed under 25 years age the North England from 1968–1995 were obtained Northern Region Young Persons' Malignant Disease Registry. The incidence was 1.2 per million year for (aged 0–14 years) 13 adults 15–24 years). Melanoma accounted 138 cases, which 16 subjects aged < 15 at diagnosis. increased females a rate 5.6 decade (95% confidence...
Abstract The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease. Here, we report that loss of sfpq leads to premature termination multiple transcripts due widespread activation previously unannotated cryptic last exons (CLEs). These SFPQ-inhibited CLEs appear preferentially long introns genes functions can...
Regulation of pre-mRNA splicing and polyadenylation plays a profound role in neurons by diversifying the proteome modulating gene expression response to physiological cues. Although most processing is thought occur nucleus, numerous regulators are also found neurites. Here, we show that U1-70K/SNRNP70, component major spliceosome, localizes RNA-associated granules zebrafish axons. We identify extra-nuclear SNRNP70 as an important regulator motor axonal growth, nerve-dependent acetylcholine...
Summary Severe drug eruptions may cause diagnostic and therapeutic difficulty when they mimic or provoke endogenous patterns of dermatosis. We report three patients with known psoriasis in whom use bupropion (Zyban®), prescribed to assist cessation smoking, led severe pustular erythrodermic exacerbation within 3–5 weeks. All were systemically unwell required hospitalization control the disease flare.
Little population-based data has been published about skin cancers in children and young adults. In this study, 200 cases of melanoma non-melanoma diagnosed under 25 years age the North England from 1968-1995 were obtained Northern Region Young Persons' Malignant Disease Registry. The incidence was 1.2 per million year for (aged 0-14 years) 13 adults 15-24 years). Melanoma accounted 138 cases, which 16 subjects aged < 15 at diagnosis. increased females a rate 5.6 decade (95% confidence...
The clinical and pathological features of 11 cases regressing keratoacanthoma are presented. These lesions were from sun‐exposed skin individuals between the ages 58 92 years short duration (2–12 months). Histologically, these showed similar consisted symmetrical shallow cup‐shaped invaginations thin atrophic epidermis with overhanging edges. underlying papillary dermis demonstrated variable degrees inflammatory infiltrate scarring. It is important to recognize as representing regressed they...
In the U.K., patients with suspected skin tumours are usually referred from a general practitioner to hospital-based dermatologist for treatment. The urgency of such referrals is currently topic political importance. We have studied case record data 162 basal cell carcinoma (BCC) establish relevance routinely being considered urgent. At presentation, mean tumour size (maximum dimension) was 7. 4 mm (median 10) and duration BCC 20.5 months 12). There no correlation (all P > 0.05) between...
SUMMARY Regulation of pre-mRNA splicing and polyadenylation plays a profound role in neurons by diversifying the proteome modulating gene expression during development response to physiological cues. Although most processing reactions are thought occur nucleus, numerous regulators also found neurites. Here, we show that U1-70K/SNRNP70, major spliceosomal component, localizes RNA-associated granules axons. We identify cytoplasmic pool SNRNP70 as an important local regulator motor axonal...