Purpose: Corneal foreign bodies (CFBs) due to occupational exposure have been largely ignored in Indian literature, especially nonmetal workers. Our study looks at a broad range of occupations and settings that contribute CFB our local population. The objective was determine the occupations, level education demographics patients presenting with acquired during work. Methods: Prospective hospital-based tertiary eye hospital Gurgaon, Haryana, India, within duration 9 months. Patients were...

Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is an extremely rare non-Langerhans cell histiocytosis. Orbital involvement even rarer and may be accompanied by lymph node involvement. Treatment options range from systemic steroids immunosuppressants to radiation debulking. We present a case of bilateral orbital cervical circumaortic lymphadenopathy.

Hereditary sensory autonomic neuropathy (HSAN) is a group of inherited disorders (total 5 types) that are associated with dysfunction and varying degrees dysfunction. HSAN type IV (HSAN-IV) or congenital insensitivity to pain anhidrosis (CIPA) rare genetic disorder in an autosomal recessive manner. We report case this very disease 3-year-old girl child, born family north India ocular features neurotrophic keratitis. The diagnosis was made clinically based on the hallmark temperature,...

Case Report A 56-year-old male patient came to us our out department (OPD) with complaints of diminution vision in the left eye since last 1 year. He gave no history any glare or difficulty at night. did not have relevant past trauma (blunt subtle, even after repeated questioning) nor ocular systemic disease. significant personal history, was a smoker, drug addiction history. spectacle wearer using bifocal distance correction +1.00 Dioptre Sphere (DS) both eyes and near +2.50DS eyes. His...

Abstract The mechanisms that enable differential gene expression in daughter cells produced by asymmetric cell divisions are not well understood. We discovered the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for this process C. elegans . During development, some dividing give rise to a survives and dies. found PSF-2 GINS2, component of CMG, necessary transcriptional burst pro-apoptotic egl-1 BH3-only, which occurs dies immediately following mother division. present...

We report that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for differential gene expression in cells produced by asymmetric cell divisions C. elegans. found elegans component, PSF-2 GINS2, necessary transcriptional upregulation of pro-apoptotic egl-1 BH3-only occurs programmed to die after they are through divisions. propose CMG's histone chaperone activity causes epigenetic changes at locus during replication mother cells, and these die. find also divergence other...

Purpose: India has the largest population of youth in world, thereby making them important contributors to “India Tomorrow”. Over 80% knowledge gained is by visual sense, school screening programs a necessity our country. Data from pre-COVID era, that is, 2017–18 was collected close 19,000 children Gurugram, Haryana, tier two city National Capital Region, India. A similar prospective observational study planned post COVID-19 (2022–23) for further analysis depict impact these areas. Methods:...

Vitreous cysts are a rare finding and rarely cause any visual disturbances. They often classified as idiopathic when their etiology cannot be determined. may congenital or acquired pigmented nonpigmented. In previous reports, it has been suggested on the basis of electron microscopy that these vitreous have originated from pigment epithelium. We present case 46-year-old female, with complaints an oval-shaped floater, causing some disturbance in her right eye. On examination, was found to...

Xanthelasma palpebrarum, a very common type of xanthoma seen in adults, is an extremely rare sighting children. To date, less than five cases the same have been reported literature. The purpose this study to report and describe clinical findings patient with juvenile xanthogranuloma. We present one such case xanthelasma 9-year-old child who our outpatient department.

We report a case of an 84-year-old female who presented following fall from standing height. There was immediate loss vision in the right eye. On day 3 admission, patient described seeing hallucinations She children playing garden while sitting hospital bed. found to have indirect traumatic optic neuropathy with associated Charles Bonnet syndrome. The underwent conservative management and on 2 weeks follow-up her eye improved hand motions. To our knowledge, there is no reported this kind literature.

We report an easily missed diagnosis of the blood-stained cornea that can simulate crystalline lens in anterior chamber (AC), especially when associated with low intraocular pressure (IOP), a rare occurrence. A 10-year-old boy presented loss vision left eye since 15 days following cricket ball injury. Ocular examination revealed amber-colored disciform appearance and visual acuity light perception. The was hypotonus. patient underwent ultrasound B-scan, which demonstrated infero-posterior...

Rhino-orbito-cerebral mucormycosis is a potentially fatal fungal infection seen in poorly controlled diabetics or immunocompromised patients who can present initially to an ophthalmologist, otorhinolaryngologist neurologist. The clinical presentation ophthalmologist may be that of painful ophthalmoplegia.The confirmation and further management the requires interdisciplinary approach. A timely diagnosis intervention life-saving. This article depicts typical fulminant course diagnostic...

Commotio retinae (CR) are a disorder of the outer retina, typically following blunt trauma to eye. CR leads visual disturbances mainly in form scotoma. clinically presents as transient gray-white discoloration retina and is diagnosed with ease. There reports presenting without any retinal but confirmed on optical coherence tomography, or infrared reflectance termed subclinical We present one such rare case clinical findings, which was overlay showing characteristic distinct hyporeflectance pattern.

We report a case of Combined hamartoma the retina and retinal pigment epithelium (CHRRPE) in 7 year old child, presenting to us our single institutional practice. CHR-RPE is rare generally benign ocular hamartoma. sporadic but can occasionally occur as part neurofibromatosis, nasopharyngeal angiofibroma, Gorlin or Poland syndrome. Vast majority previously documented cases have been published prior advent optical coherence tomography (OCT).Failure distinguish it from serious malignancies such...

A cell's size affects the likelihood that it will die. But how is cell controlled in this context and does impact commitment to death fate? We present evidence caspase CED-3 interacts with RhoGEF ECT-2 C. elegans neuroblasts generate ‘unwanted’ cells. propose interaction promotes polar actomyosin contractility, which leads unequal neuroblast division generation of a daughter below critical ‘lethal’ threshold. Furthermore, we find hyperactivation reduces sizes unwanted Importantly, increases...

Background: The largest population of youth in the world is with INDIA, and this makes them most important contributors to our economy future country. Sight main driving sense for knowledge skill development, thereby it perfect ensure that proper timely eyecare provided INDIA a safe stable Thus came idea an effective school screening program provide basic eye treatment when required children going age also gather information refractive error prevalence group population. Methods: SCHOOL...

We report a case of young patient with sudden drop in vision and lower limb weakness. On examination was found to have left eye disc edema abnormal CNS function. further investigation, the diagnosed optic neuritis associated transverse myelitis-a syndrome referred neuromyelitis optica or Devic's Disease. This emphasizes need for timely intervention prevent permanent loss.

This case reports on a 2 1/2 -year-old male child with GAPO syndrome, rare autosomal recessive condition characterized by growth retardation (G), alopecia (A), pseudoanodontia (P), and optic atrophy (O). Since Anderson Pindborg in 1947 first described this close to 30 individuals have been reported diagnosis. Often history of consanguinity is noted, as our case, condition. The phenotype condition, initially thought be result ectodermal dysplasia, can attributed the accumulation extracellular...