A5045449682- Musculoskeletal pain and rehabilitation
- Frailty in Older Adults
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutrition and Health in Aging
- Genetics, Aging, and Longevity in Model Organisms
- Myofascial pain diagnosis and treatment
- MicroRNA in disease regulation
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Mesenchymal stem cell research
- Sports injuries and prevention
- Balance, Gait, and Falls Prevention
- Migraine and Headache Studies
- Botulinum Toxin and Related Neurological Disorders
- Psychosomatic Disorders and Their Treatments
- Extracellular vesicles in disease
- Phytoestrogen effects and research
- Nutritional Studies and Diet
- Sirtuins and Resveratrol in Medicine
- Lower Extremity Biomechanics and Pathologies
- Adipose Tissue and Metabolism
- Foot and Ankle Surgery
- Infant Development and Preterm Care
- Eating Disorders and Behaviors
- Spine and Intervertebral Disc Pathology
Universitat de València
2016-2025
Instituto de Salud Carlos III
2017-2025
Institut d'Investigació Sanitària Pere Virgili
2024-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2024-2025
Universitat Rovira i Virgili
2025
Molina Center for Energy and the Environment
2023
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2022
Hospital Clínico Universitario de Valencia
2019-2022
Centro de Investigación Biomédica en Red
2018-2021
Centre for Biomedical Network Research on Rare Diseases
2017-2018
Objectives To ascertain whether indicators of oxidative damage to lipids (malondialdehyde ( MDA )) and proteins (protein carbonylation) are biomarkers frailty, after adjusting for age, sex, other possible confounders. Design Cross‐sectional cohort study. Setting Community. Participants Toledo Study Healthy Aging participants (N = 742, aged 65–95), classified as frail (n 54), prefrail 278) nonfrail 410) according the Fried criteria. Measurements Blood plasma was obtained using centrifugation...
Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain and other physical psychological features. In this study, we aimed to analyze the effect of low-intensity exercise (PE) program, combining endurance training coordination, on aspects (i.e., catastrophizing, anxiety, depression, stress), perception acceptance, pressure threshold (PPT), quality life conditioning self-perceived functional capacity, power velocity) in women with FM. For purpose, randomized controlled trial...
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes aging frailty are particularly interesting. We treated old animals small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) young animals, we found improvement in several parameters usually altered aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, renal function, well important decrease frailty....
Amyloid-β (Aβ) clearance from brain, which is decreased in Alzheimer's disease, facilitated by apolipoprotein E (ApoE). ApoE upregulated activation of the retinoid X receptor moiety RXR/PPARγ dimeric receptor. Genistein, a non-toxic, well-tested, and inexpensive drug activates o ther PPARγ. Treatment an disease mouse model with genistein results remarkable rapid improvement various parameters cognition, such as hippocampal learning, recognition memory, implicit odor discrimination. This...
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies detect and quantify 137 ether lipids define phenotype healthy humans exceptional Ether were chosen because their antioxidant properties ability modulate stress. Our results demonstrate that specific signature can be obtained the centenarian state. This comprises higher level alkyl...
LRP1-targeted St-Cl–polyglutamate conjugates as multivalent neuroprotective/neurotrophic therapeutics for Alzheimer’s disease.
Aging | doi:10.18632/aging.101078. Consuelo Borras, Kheira M. Abdelaziz, Juan Gambini, Eva Serna, Marta Inglés, Monica de la Fuente, Idoia Garcia, Ander Matheu, Paula Sanchís, Angel Belenguer, Alessandra Errigo, Juan- Antonio Avellana, Ana Barettino, Carla Lloret-Fernández, Nuria Flames, Gianni Pes, Leocadio Rodriguez-Mañas, Jose Viña
Aging is accompanied by the accumulation of senescent cells that alter intercellular communication, thereby impairing tissue homeostasis and reducing organ regenerative potential. Recently, administration mesenchymal stem (MSC)-derived extracellular vesicles has proven to be more effective less challenging than current cell-based therapies. Extracellular (EVs) contain a cell-specific cargo proteins, lipids nucleic acids are released taken up probably all cell types, inducing functional...
Antioxidant properties of resveratrol have been intensively studied for the last years, both in vivo and vitro. Its bioavailability after an oral dose is very low therefore it important to make sure that plasma concentrations free are sufficient enough be active as antioxidant.In present study, using nutritionally relevant resveratrol, we aim confirm its antioxidant capacity on reducing peroxide levels look molecular pathway involved this effect.We used mammary gland tumor cells (MCF-7),...
Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following certain number of passages, loosing their stemness properties. Long-term culture at 21% (ambient oxygen tension) compared 3–6% tension (physiological caused oxidative stress-related premature senescence, as evidenced by increased β-galactosidase activity and lysil oxidase expression, which mediated...
The objective of this work was to determine the specific mechanisms by which resveratrol inhibits lipogenesis and stimulates lipolysis.Twelve male mice were individually introduced into a metabolic cage for 24 h measure basal rate, prior intervention. They randomly divided two groups, (RSV) control (C), administered intraperitoneally or vehicle, respectively, consecutive days. After h, energy expenditure again determined before sacrificed. Protein gene expression different enzymes related...
Understanding the functional status of people with Alzheimer Disease (AD), both in a single (ST) and cognitive dual task (DT) activities is essential for identifying signs early-stage neurodegeneration. This study aims to compare performance quality several tasks using sensors embedded an Android device, among at different stages without dementia. The secondary aim analyze effect on mobility tasks.This cross-sectional including 22 participants control group (CG), 18 mild AD moderate AD. They...
This study aims to assess the effect of combining virtual walking (VW) therapy with a physical exercise (PE) program compared PE alone on lower limb strength and muscle activation in people incomplete spinal cord injury (iSCI). 38 participants performed 3 sessions/week during 6 weeks Experimental Intervention (EI): VW PE; or Control intervention (CI): Placebo-VW PE. Strength main muscles were assessed. EI group exhibited general increase after (T2), (16.31–34.72 N), maintained this...