A5070995353- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Circadian rhythm and melatonin
- Light effects on plants
- Pluripotent Stem Cells Research
Instituto de Biomedicina de Valencia
2021-2025
Summary How nervous systems coordinate the generation of specific neuron types with gene expression plasticity and how these mechanisms impact cell type evolution is unknown. Here we use Caenorhabditis species to study neuron-type robustness, evolution, using VC4 VC5 cholinergic motoneurons as models. In C. elegans , found that epigenetic silencing through histone 3 lysine 9 methylation (H3K9me) necessary suppress serotonin reuptake mod-5/ Sert a serotonergic phenotype in cells. contrast,...
During development, signal-regulated transcription factors (TFs) act as basal repressors and upon signalling through morphogens or cell-to-cell shift to activators, mediating precise transient responses. Conversely, at the final steps of neuron specification, terminal selector TFs directly initiate maintain neuron-type specific gene expression enduring functions activators. C . elegans contains 3 types serotonin synthesising neurons that share biosynthesis pathway genes but not other...