A5050427973- Nanoplatforms for cancer theranostics
- Chronic Kidney Disease and Diabetes
- Photoacoustic and Ultrasonic Imaging
- TGF-β signaling in diseases
- Quantum Dots Synthesis And Properties
- Luminescence Properties of Advanced Materials
- Renal Diseases and Glomerulopathies
- Tea Polyphenols and Effects
- Advanced Glycation End Products research
- Renal and related cancers
- Photodynamic Therapy Research Studies
- Animal Genetics and Reproduction
- Chalcogenide Semiconductor Thin Films
- Adipokines, Inflammation, and Metabolic Diseases
- Porphyrin and Phthalocyanine Chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Phytochemicals and Antioxidant Activities
- Advanced biosensing and bioanalysis techniques
- Antioxidant Activity and Oxidative Stress
- Optical Coherence Tomography Applications
- Luminescence and Fluorescent Materials
- Biotin and Related Studies
- Orbital Angular Momentum in Optics
- Acute Kidney Injury Research
Universidad Autónoma de Madrid
2005-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2015-2022
Instituto Cajal
2022
University of Central Florida
2020
University of Pennsylvania
2000-2003
University City Science Center
2002
Hospital Universitario Príncipe de Asturias
2001
Instituto de Salud Carlos III
2001
Thomas Jefferson University
2000
University of Minnesota
1997
Emerging evidence suggests that transforming growth factor-β (TGF-β) is an important mediator of diabetic nephropathy. We showed previously short-term treatment with a neutralizing monoclonal anti-TGF-β antibody (αT) in streptozotocin-diabetic mice prevents early changes renal hypertrophy and increased matrix mRNA. To establish overactivity the TGF-β system mediates functional structural more advanced stages nephropathy, we tested whether chronic administration αT insufficiency...
In this study, we report on the remarkable two-photon excited fluorescence efficiency in "biological window" of CaF2:Tm3+,Yb3+ nanoparticles. On basis strong Tm3+ ion emission (at around 800 nm), tissue penetration depths as large 2 mm have been demonstrated, which are more than 4 times those achievable based visible emissions comparable CaF2:Er3+,Yb3+ The outstanding depth, together with thermal sensitivity demonstrated here, makes nanoparticles ideal candidates multifunctional nanoprobes...
The technological development of quantum dots has ushered in a new era fluorescence bioimaging, which was propelled with the advent novel multiphoton microscopes. Here, potential use CdSe been evaluated as fluorescent nanothermometers for two-photon microscopy. In addition to enhancement spatial resolution inherent any excitation processes, (near-infrared) leads temperature sensitivity emission intensity much higher than that achieved under one-photon (visible) excitation. peak wavelength is...
The future perspective of fluorescence imaging for real in vivo application are based on novel efficient nanoparticles which is able to emit the second biological window (1000–1400 nm). In this work, potential Nd 3+ ‐doped LaF 3 (Nd :LaF ) reported bioimaging both first and windows their three main emission channels ions: 4 F 3/2 → I 9/2 , 11/2 13/2 that lead emissions at around 910, 1050, 1330 nm, respectively. By systematically comparing relative intensities, penetration depths subtissue...
Abstract The emergence of luminescence nanothermometry in bio and nanomedicine has enabled achievements outside the reach conventional techniques. For instance, it provided real‐time monitoring vivo thermal therapies tumors, a mandatory requirement for these techniques to work safely efficiently. However, reliability intratumoral readings is currently question due presence artefacts caused by inhomogeneous optical properties biological tissues. This demonstrates how possible avoid, under...
Abstract. High ambient glucose exerts its injurious effects on renal cells through nonenzymatic and enzymatic pathways, including altered signal transduction upregulation of the transforming growth factor-β (TGF-β) system. Extracellular signal-regulated kinase (ERK), a member mitogen-activated protein (MAPK) cascade, is activated in mesangial cultured high glomeruli diabetic rats. However, biologic consequences ERK activation kidney have not been investigated. To clarify role activation,...
Background. The podocyte is bathed in an angiotensin II (AngII)-rich ultrafiltrate, but the impact of AngII on pathobiology not well known. Because podocytes play a direct role glomerular basement membrane (GBM) thickening diabetes, α3(IV) collagen chain was examined. Podocyte expression may involve transforming growth factor-β (TGF-β) and vascular endothelial factor (VEGF) systems.
Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential the life sciences. In addition, such nanostructures could also offer therapeutic capabilities achieve a wider variety of multifunctionalities. this work, encapsulation both magnetic infrared emitting into polymeric matrix leads magnetic-fluorescent HNS multimodal imaging...
During the last decade inorganic luminescent nanoparticles that emit visible light under near infrared (NIR) excitation (in biological window) have played a relevant role for high resolution imaging of cancer. Indeed, semiconductor quantum dots (QDs) and metal nanoparticles, mostly gold nanorods (GNRs), are already commercially available this purpose. In work we review which is being by relatively new class based on lanthanide ion doped nanocrystals, to target image cancer cells using...
This article demonstrates how controlled hyperthermia at the cellular level can be achieved.The method is based on simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods).Real-time spectral analysis dot emission provides a detailed feedback about thermal loading caused by gold nanorods excited plasmon frequency. Based this approach, dosimetry assessed in such way that infrared laser (heating) power required to...
Photodynamic therapy (PDT) is a treatment modality for different forms of cancer based on the combination light, molecular oxygen, and photosensitizer (PS) compound. When activated by PS generates reactive oxygen species leading to tumor destruction. Phthalocyanines are compounds that have already shown be efficient PSs PDT. Several examples carbohydrate substituted phthalocyanines been reported, assuming presence moieties could improve their selectivity. This work describes photoeffects...
Arterial hypertension has a high prevalence in the population and is considered both cardiovascular disease an important risk factor for development of other diseases. Tea consumption shows antihypertensive effects due to its composition terms bioactive substances such as flavan-3-ols xanthines. The aim this study was assess possible beneficial two tea extracts, one white (ADM® White Tea; WTE) another composed mixture black green Complex; CTE), on alterations induced by angiotensin II...
The inadequate safety and efficacy of chemotherapy led cancer medicine to focus on localizing drug delivery the target. Thermoresponsive nanocarriers (liposomes polymeric networks) exploit local hyperthermia trigger...
<title>Abstract</title> Intracoronary stents have revolutionized the treatment of coronary obstructions, allowing for minimally invasive procedures and significantly enhancing both therapeutic efficacy patient quality life. Despite their clinical success, once implanted, act as passive elements, incapable providing real-time data on treated artery, thereby limiting early diagnosis post-implantation complications such inflammation, restenosis, or recurrence atheromatous plaques. In this...
1 Puromycin aminonucleoside (PAN)-induced nephrosis is a model of human minimal change disease. In rats, PAN induces nephrotic-range proteinuria, renal epithelial cell (podocyte) damage, infiltration mononuclear leukocytes, and apoptosis several types. 2 Retinoic acid (RA) modulates wide range biological processes, such as inflammation apoptosis. Since damage by characterized inflammatory death, the effect treatment with all-trans RA (tRA) was examined in cultured differentiated podocyte. 3...
Regenerative properties of skin decrease with age, and thus, the search for substances that minimize cutaneous ageing has increased in last few years. The secretion mollusc Cryptomphalus Aspersa (SCA) is a natural product bears regenerative when applied topically. purpose this work to study vitro effects SCA on cell proliferation migration, as well cell-cell (E-cadherin β-catenin) cell-substrate (vinculin β1-integrin) adhesion proteins expression, using human keratinocyte line (HaCaT cells)...
Semiconductor quantum dots of few nanometers have demonstrated a great potential for bioimaging. The size determines the emitted color, but it is also expected to play an important role in image brightness. In this work, dependence fluorescence yield highly thermal sensitive CdTe has been systematically investigated by lens spectroscopy. It found that optimum reached 3.8-nm dots. presence corroborated both one-photon excited experiments and two-photon microscopy dot-incubated cancer cells....