A5053908688- Luminescence Properties of Advanced Materials
- Nanoplatforms for cancer theranostics
- Radiation Detection and Scintillator Technologies
- ZnO doping and properties
- Photodynamic Therapy Research Studies
- Semiconductor materials and devices
- Mast cells and histamine
- Electronic and Structural Properties of Oxides
- Radiation Therapy and Dosimetry
- Luminescence and Fluorescent Materials
- Earthquake Detection and Analysis
- Neuroblastoma Research and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Glass properties and applications
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Intraperitoneal and Appendiceal Malignancies
- Quantum Dots Synthesis And Properties
- Machine Learning in Materials Science
- Particle Detector Development and Performance
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Catalytic Processes in Materials Science
- Atomic and Subatomic Physics Research
- Advanced Photocatalysis Techniques
University of Milano-Bicocca
2016-2025
Materials Sciences (United States)
2024
National Interuniversity Consortium of Materials Science and Technology
2024
Czech Academy of Sciences, Institute of Physics
2021-2023
Czech Academy of Sciences, Institute of Physics of Materials
2022
University of Bergen
2021
Institut Gustave Roussy
2014-2021
Mylan (Switzerland)
2018
Istituto Officina dei Materiali
2018
Instituto de Física de Cantabria
2015
Large Stokes shift fast emitters show a negligible reabsorption of their luminescence, feature highly desirable for several applications such as fluorescence imaging, solar-light managing, and fabricating sensitive scintillating detectors medical imaging high-rate high-energy physics experiments. Here we obtain high efficiency luminescence with significant by exploiting fluorescent conjugated acene building blocks arranged in nanocrystals. Two ligands equal molecular length connectivity, yet...
Mitogenic activity of bone marrow-derived mouse mast cells and cell lines P815 MC/9 on B T lymphocytes is present in their culture supernatants. To identify this activity, were incubated serum-free medium the supernatant was subjected to differential centrifugation, which resulted two fractions, hypodense dense fraction (pellet). When analyzed for mitogenic spleen cells, all found be associated with fraction. Electron microscopy studies revealed presence small vesicles called exosomes a...
The future perspective of fluorescence imaging for real in vivo application are based on novel efficient nanoparticles which is able to emit the second biological window (1000–1400 nm). In this work, potential Nd 3+ ‐doped LaF 3 (Nd :LaF ) reported bioimaging both first and windows their three main emission channels ions: 4 F 3/2 → I 9/2 , 11/2 13/2 that lead emissions at around 910, 1050, 1330 nm, respectively. By systematically comparing relative intensities, penetration depths subtissue...
Small animal deep-tissue fluorescence imaging in the second Biological Window (II-BW, 1000-1350 nm) is limited by presence of undesirable infrared-excited, infrared-emitted (900-1700 autofluorescence whose origin, spectral properties and dependence on strains still unknown. In this work, infrared laser-induced whole body heating five different mouse with distinct coat colors (black, grey, agouti, white nude) has been systematically investigated. While neither nor magnitude organ vary...
Abstract Fast photoluminescence and scintillation with a Stokes shift larger than 1 eV is achieved in hetero‐ligand metal–organic framework (MOF) crystals comprising inorganic linking nodes fluorescent conjugated ligands. By finely engineering the MOF composition use of ligands strictly complementary emission absorption properties highly delocalized molecular electronic orbitals, singlet excitons diffusion enhanced through ligand framework, fully exploiting both Förster Dexter energy...
In this work a strategy for the control of structure and optical properties inorganic luminescent oxide-based nanoparticles is presented. The nonaqueous sol–gel route found to be suitable synthesis hafnia their doping with rare earths (RE) ions, which gives rise luminescence either under UV X-ray irradiation. Moreover, we have revealed capability technique achieve low-temperature stabilization cubic phase through effective incorporation trivalent RE ions into crystal lattice. Particular...
Defect engineering operated on metal oxides by chemical and structural modifications may strongly affect properties suitable for various applications such as photoelectrochemical behavior, charge transport, luminescence. In this work, we report the tunable optical features observed in undoped monoclinic HfO2 nanocrystals their dependence of material at nanoscale. Transmission electron microscopy together with X-ray diffraction surface area measurements were used to determine fine...
// Erika Vacchelli 1,2,3,4,5 , Michaela Semeraro 1,6,7 David P. Enot 1,2,3,8 Kariman Chaba 1,2,3,4 Vichnou Poirier Colame Peggy Dartigues 9 Aurelie Perier Irene Villa 10 Sylvie Rusakiewicz Caroline Gronnier 11,12 Diane Goéré 1,13 Christophe Mariette Laurence Zitvogel 1,6,7,14,* and Guido Kroemer 1,2,3,4,5,8,15,* 1 Gustave Roussy Cancer Campus, Villejuif, France 2 INSERM, U1138, Paris, 3 Equipe 11 Labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 4...
The multikinase inhibitor regorafenib (BAY 73–4506) exerts both anti-angiogenic and anti-tumorigenic activity in adult solid malignancies mainly advanced colorectal cancer gastrointestinal stromal tumors. We intended to explore preclinically the potential of against pediatric alone combination with anticancer agents guide development plan. In vitro effects on cell proliferation were screened 33 tumor lines Innovative Therapies for Children Cancer (ITCC) panel covering five malignancies....
MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis metastasis. upregulation further represents an escape mechanism to various anticancer treatments including VEGF signaling inhibitors. We developed in vitro a resistance model pan-VEGFR inhibition explored the simultaneous of VEGFR models vivo using cabozantinib, inhibitor tyrosine kinases VEGFR2, MET, AXL RET. Resistance IGR-N91-Luc under continuous exposure pressure VEGFR1-3 axitinib was associated with...
Multicomponent nanomaterials consisting of dense scintillating particles functionalized by or embedding optically active conjugated photosensitizers (PSs) for cytotoxic reactive oxygen species (ROS) have been proposed in the last decade as coadjuvant agents radiotherapy cancer. They designed to make scintillation-activated sensitizers ROS production an aqueous environment under exposure ionizing radiations. However, a detailed understanding global energy partitioning process occurring during...
Hybrid nanoscintillators, which feature a heavy inorganic nanoparticle conjugated with an organic emitter, represent promising avenue for advancements in diverse fields, including high-energy physics, homeland security, and biomedicine. Many research studies have shown the suitability of hybrid nanoscintillators radiation oncology, showing potential to improve therapeutic results compared traditional protocols. In this work, we studied SiO2/ZnO nanoparticles functionalized porphyrin as...
Nanomedicine is emerging as promising approach for the implementation of oncological methods. In this review, we describe most recent methods exploiting heavy nanoparticles and hybrid nanomaterials aiming at improving traditional X-rays-based treatments. High-Z are proposed radiosensitizers due to their ability stop ionizing radiation increase locally delivered therapeutic dose. Other working catalysts can generate reactive oxygen species upon X-rays exposure. Thanks high toxicity...
Effective and accessible treatments for Alzheimer's disease (AD) are urgently needed. Soluble Aβ oligomers identified as neurotoxic species in AD targeted antibody-based drug development to mitigate cognitive decline. However, controversy exists concerning their efficacy safety. In this study, an alternative strategy is proposed inhibit the formation of by selectively oxidizing specific amino acids sequence, thereby preventing its aggregation. Targeted oxidation achieved using biocompatible...
Abstract Scintillating materials emit light when exposed to ionizing radiation or particles and are used for the detection of nuclear threats, medical imaging, high‐energy physics, other usages. For some these applications, it is vital distinguish neutrons charged from γ‐rays. This achievable by pulse shape discrimination (PSD), a time‐gated technique, which exploits that scintillation kinetics can depend on nature incident radiation. However, proves difficult realize efficient PSD with...
Fast emitting polymeric scintillators are requested in advanced applications where high speed detectors with a large signal-to-noise ratio needed. However, their low density implies weak stopping power of energy radiation and thus limited light output sensitivity. To enhance performance, can be loaded dense nanoparticles (NPs). We investigate the properties series by means photoluminescence scintillation spectroscopy, comparing standard composite system hafnium dioxide (HfO2) NPs. The...
Bone marrow-derived mouse mast cells (BMMC) and cell lines P815 MC9 have recently been shown to induce antigen-independent B T lymphocyte activation. It has demonstrated that a physical contact between lymphocytes is not necessary since supernatants contain full activity. Electron microscopy studies revealed the presence in of small vesicles called exosomes with heterogeneous size from 60 100 nm diameter. When cocultured spleen cells, purified blast formation, proliferation as well IL-2...
The first use of Eu<sup>3+</sup>-doped hafnium dioxide nanocrystals for optical imaging cellular systems is reported.
The present study aims at supplying a more in-depth picture of the generation environmentally persistent free radicals (EPFRs) from phenol (PhOH) on ZnO/SiO2 systems, by exploring properties ZnO nanoparticles (NPs) with different intrinsic defectivity grown highly porous silica spherical (ZnO/SiO2_S) and wormlike morphology (ZnO/SiO2_W). In detail, besides an extensive structural, morphological, surface investigation, occurrence inequivalent defect centers in samples was tracked...
Charge trapping phenomena and recombination centers were studied in three Cs2HfCl6 single crystals of slightly different stoichiometry grown by the vertical Bridgeman method. Electron paramagnetic resonance (EPR) spectra measured both before after X-ray irradiation show creation two distinct Vk centers. One them was Vk(a) already known from a recent work "R. Král, V. Babin, E. Mihoková, M. Buryi, Laguta, K. Nitsch, Nikl, Luminescence Trapping Single Crystals: Optical Magnetic Resonance...
This study addresses the relationship between material morphology (size, growth parameters and interfaces) optical emissions in ZnO through an experimental approach, including effect of different dimensions from bulk to nano-size, excitations, sources ionizing radiation. Silica supported nanoparticles ligand capped are synthesized a sol–gel process hot injection method, respectively. Their properties investigated by radioluminescence, steady-state time-resolved photoluminescence, compared...