To analyze oxidative stress in primary open-angle glaucoma (POAG).A case-control study including 90 eyes of patients who needed antiglaucomatous surgery the course POAG (glaucoma group, n=50) and from were operated nonpathologic cataracts (cataract n=40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) test total antioxidant status aqueous humor samples both groups determined. Statistical analyses carried out relation to...

The aim of this study is to evaluate molecules involved in oxidative stress (OS), inflammation, angiogenesis, and apoptosis, discern which these are more likely be implicated proliferative diabetic retinopathy (PDR) macular edema (DME) by investigating the correlation between them plasma (PLS) vitreous body (VIT), as well examining data obtained from ophthalmological examinations. Type 2 (T2DM) patients with PDR/DME (PDRG/DMEG; n = 112) non-DM subjects surrogate controls (SCG 48) were...

Background: Women, and those older than 65 years of age, are particularly susceptible to dry eye disorders (DEDs). Inflammation is clearly involved in the pathogenesis DEDs, there mounting evidence on antioxidant antiinflammatory properties essential polyunsaturated fatty acids (EPUFAs). Objective: To analyze whether a combined formulation antioxidants long-chain EPUFAs may improve evolution DEDs. Methods: We used prospective study address relationship between risk factors, clinical...

Abstract Purpose To evaluate the effect of oral antioxidant supplementation ( OAS ) on primary open‐angle glaucoma POAG over a 2‐year follow‐up period. Patients and methods In this open‐label, randomized controlled trial, 117 eyes patients with mild or moderate intraocular pressure under control topical antiglaucoma medications were recruited randomly divided into three groups according to supplementation: (1) ICAPS R ® – Alcon Laboratories, n = 26); (2) without ω ‐3 fatty acids OFTAN MACULA...

Purpose This study was designed to evaluate the effect of antioxidant supplementation on diabetic retinopathy (DR) over a 5-year follow-up period. To our knowledge, this is first such clinical trial performed. Methods We recruited 105 type 2 patients with nonproliferative DR. A complete ophthalmic checkup and plasma determination oxidative (malonyldialdehyde [MDA]) parameters (total status [TAS]) were obtained as baseline. One part cohort randomly assigned oral at nutritional doses. The same...

Background: The aim of this study was to assess the expression cytokines/chemokines in tears from patients with non-advanced primary open-angle glaucoma and non-severe dry eye disease versus healthy controls. Methods: This prospective, observational cohort enrolled confirmed or suspected who received any prostaglandin analogue monotherapy for longer than 6 months, disease, Expression interleukin-1β, interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10,...

Aims/Purpose: Biomarkers improve our knowledge of the risk factors and pathogenic mechanisms eye disorders. Validation biomarkers is crucial for addressing an effective translation to clinical practice. We aimed find correlation between oxidative stress (OS) inflammation (INF) obtained from two commonly sampled ocular fluids: tears aqueous humor. Methods: A longitudinal, prospective, case‐control study was conducted in 220 participants that were divided into: patients diagnosed primary...

Aims/Purpose: Biomarkers improve our knowledge of the risk factors and pathogenic mechanisms eye disorders. Validation biomarkers is crucial for addressing an effective translation to clinical practice. We aimed find correlation between oxidative stress (OS) inflammation (INF) obtained from two commonly sampled ocular fluids: tears aqueous humor. Methods: A longitudinal, prospective, case‐control study was conducted in 220 participants that were divided into: patients diagnosed primary...

Aims/Purpose: Migraine is a disabling and chronic neurological disease characterized by recurrent attacks that can lead to ocular systemic complications. Several studies have investigated changes in retinal vascular density structure migraine patients. This study aims evaluate structural of the retina patients with (with without aura) before after one‐year treatment anti‐calcitonin‐gene‐related peptide (CGRP) monoclonal antibodies. Methods: Ten affected (MwA) aura (MwoA) ten healthy controls...

Aims/Purpose: Pseudoexfoliation glaucoma (PEG), is the most prevalent of secondary glaucomas, characterized by accumulation fibrillar extracellular material in anterior eye chamber. The miRNAs are regulators gene expression, as epigenetic effectors. Our aim to identify candidate that may be involved PEG physiopathology. Methods: A collaborative, longitudinal, prospective, case‐control study was set up 120 participants, both sexes, were classified as: patients ( n = 60) and healthy...

Aims/Purpose: To integrate clinical and molecular data that allow us to identify diagnostic prognostic biomarkers of dry eye disease (DED) in primary open‐angle glaucoma (POAG). Methods: A cross‐sectional case‐control study consisting 182 participants both sexes, was done. Volunteers were classified into 4 groups: healthy controls (CG; n = 50), DED group ( 42), POAG (PG; 44), DED+POAG 46). All underwent a complete systematic medical history, filled out the questionnaires, subjected...

Aims/Purpose: Amino acids have been proposed as preclinical biomarkers of the risk developing neurodegenerative and metabolic diseases. We used proton nuclear magnetic resonance (1H‐NMR) in tears for first time to investigate alterations essential amino patients with primary open‐angle glaucoma (POAG). Methods: planned an analytical pilot case‐control study 30 participants aged 40‐80 years, divided into: POAG group ( n = 11) control (CG; 19). Tears were obtained from each eye using...