A5025757732- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Neurological Disorders and Treatments
- Retinal and Optic Conditions
- Advanced Glycation End Products research
- Antioxidant Activity and Oxidative Stress
- Anesthesia and Pain Management
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Macular Surgery
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Flavonoids in Medical Research
- Cerebral Venous Sinus Thrombosis
- Retinoids in leukemia and cellular processes
- Retinopathy of Prematurity Studies
- Traumatic Ocular and Foreign Body Injuries
- Hallucinations in medical conditions
- Systemic Lupus Erythematosus Research
Universidad de Murcia
2015-2024
Hospital General Universitario Morales Meseguer
2018-2024
Instituto de Salud Carlos III
2015-2024
Instituto Murciano de Investigación Biosanitaria
2018-2024
Instituto de Investigación de Enfermedades Raras
2024
Hospital Reina Sofía de Murcia
2013-2023
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2015-2023
Spanish Clinical Research Network
2022
Universitat de València
2008-2021
Semmelweis University
2020
To analyze oxidative stress in primary open-angle glaucoma (POAG).A case-control study including 90 eyes of patients who needed antiglaucomatous surgery the course POAG (glaucoma group, n=50) and from were operated nonpathologic cataracts (cataract n=40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) test total antioxidant status aqueous humor samples both groups determined. Statistical analyses carried out relation to...
Abstract Purpose To evaluate the effect of oral antioxidant supplementation ( OAS ) on primary open‐angle glaucoma POAG over a 2‐year follow‐up period. Patients and methods In this open‐label, randomized controlled trial, 117 eyes patients with mild or moderate intraocular pressure under control topical antiglaucoma medications were recruited randomly divided into three groups according to supplementation: (1) ICAPS R ® – Alcon Laboratories, n = 26); (2) without ω ‐3 fatty acids OFTAN MACULA...
Purpose This study was designed to evaluate the effect of antioxidant supplementation on diabetic retinopathy (DR) over a 5-year follow-up period. To our knowledge, this is first such clinical trial performed. Methods We recruited 105 type 2 patients with nonproliferative DR. A complete ophthalmic checkup and plasma determination oxidative (malonyldialdehyde [MDA]) parameters (total status [TAS]) were obtained as baseline. One part cohort randomly assigned oral at nutritional doses. The same...
Glaucoma has no cure and is a sight-threatening neurodegenerative disease affecting more than 100 million people worldwide, with primary open angle glaucoma (POAG) being the most globally prevalent clinical type. Regulation of gene expression networks, its multifactorial pathways involved in are landmarks for ophthalmic research. MicroRNAs (miRNAs/miRs) small endogenous non-coding, single-stranded RNA molecules (18–22 nucleotides) that regulate expression. An analytical, observational,...
Glaucoma is a chronic neurodegenerative disease, which the leading cause of irreversible blindness worldwide. As response to high intraocular pressure, clinical and molecular glaucoma biomarkers indicate biological state visual system. Classical uncovering novel development progression, follow-up, monitoring treatment are key objectives improve vision outcomes. While imaging field has successfully validated disease there still considerable need for developing new early glaucoma, that is, at...
We have studied the global risk of retinopathy in a Mediterranean population type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants distributed into two main groups: (1) T2DMG (with (+DR) or without (-DR)) (2) controls (CG). Participants randomly assigned (+A/ω3) not (-A/ω3) with daily pill Nutrof Omega (R) for 18...
To compare thicknesses of intraretinal layers segmented by spectral-domain optical coherence tomography (SD-OCT) between autism spectrum disorder (ASD) and neurotypical (NT) individuals.We performed 2 scans on 108 eyes from 54 participants (27 high-functioning ASD 27 age- sex-matched NT subjects): macular fast volume peripapillary retinal nerve fiber layer (pRNFL). Macula was automatically segmented. The mean foveal thickness nine different the pRNFL sectors were considered. Data right left...
Our aim was to provide, for the first time, reference thickness values SD-OCT posterior pole algorithm (PPA) available Spectralis OCT device (Heidelberg Engineering, Heidelberg, Germany) and analyze correlations with age, gender axial length. We recruited 300 eyes of healthy Caucasian subjects between 18 84 years. By PPA, composed 64 (8 × 8) cells, we analyzed following macular layers: retinal nerve fiber layer (RNFL), ganglion cell (GCL), inner plexiform (IPL), nuclear (INL), outer (OPL),...
Purpose This study deals with the role of topical administration dorzolamide eyedrops on oxidative/antioxidant status aqueous humor in patients primary openangle glaucoma (POAG). Methods A case-control including 130 distributed into three groups was carried out: 1) POAG without instillation (GG; n=34); 2) (DG; n=36); and 3) subjects cataracts (comparative group, CG; n=60). Oxidative activity measured by malondialdehyde determination thiobarbituric acid reactive substances assay. Antioxidant...
Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated oxidative stress (OS) effects of a daily, core nutritional supplement regimen containing antioxidants omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out 480 participants [287 T2DM patients with (+)/without (-) diabetic retinopathy (DR) 193 healthy controls (CG)], randomly assigned to daily pill A/ω3. Periodic evaluation through 38 months...
Open-angle glaucoma (OAG), the most prevalent clinical type of glaucoma, is still main cause irreversible blindness worldwide. OAG a neurodegenerative illness for which important risk factor elevated intraocular pressure (IOP). Many questions remain unanswered about OAG, such as whether nutritional or toxic habits, other personal characteristics, and/or systemic diseases influence course glaucoma. As such, in this study, we performed multicenter analytical, observational, case–control study...