A5063809166- Immune Cell Function and Interaction
- Corneal surgery and disorders
- T-cell and B-cell Immunology
- Ocular Surface and Contact Lens
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Organ Transplantation Techniques and Outcomes
- Reproductive System and Pregnancy
- Transplantation: Methods and Outcomes
- Ophthalmology and Visual Impairment Studies
- Atmospheric chemistry and aerosols
- Atmospheric aerosols and clouds
- Microscopic Colitis
- 3D Surveying and Cultural Heritage
- Retinal Imaging and Analysis
- Endodontics and Root Canal Treatments
- Remote Sensing and LiDAR Applications
- Multiple Myeloma Research and Treatments
- Anatomy and Medical Technology
- Ocular Diseases and Behçet’s Syndrome
Fundación Centro Tecnológico de la Información y la Comunicación
2020-2024
Universidad de Murcia
2009-2024
Centro Tecnológico del Mueble y la Madera de la Región de Murcia
2020-2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013-2019
Instituto Murciano de Investigación Biosanitaria
2016-2019
Hospital Universitario Virgen de la Arrixaca
2011-2016
Glaucoma has no cure and is a sight-threatening neurodegenerative disease affecting more than 100 million people worldwide, with primary open angle glaucoma (POAG) being the most globally prevalent clinical type. Regulation of gene expression networks, its multifactorial pathways involved in are landmarks for ophthalmic research. MicroRNAs (miRNAs/miRs) small endogenous non-coding, single-stranded RNA molecules (18–22 nucleotides) that regulate expression. An analytical, observational,...
A group of eight Spanish lidars was formed in order to extend the European Aerosol Research Lidar Network-Advanced Sustainable Observation System (EARLINET-ASOS) project. This study presents intercomparisons at hardware and software levels. Results system are based on range-square-corrected signals cases where viewed same atmospheres. Comparisons were also made for aerosol backscatter coefficients 1064 nm (2 systems) 532 (all systems), extinction systems). In total, three field campaigns...
In Brief Background Killer immunoglobulin-like receptors (KIRs) bind human leukocyte antigen (HLA) class-I (HLA-I) ligands and regulate functions of natural killer cells subsets T cells. KIR/HLA-I interactions allow predicting cell alloreactivity in hematopoietic stem transplantation HLA-compatible kidney transplants, but its meaning liver remains controversial. Methods KIR HLA genotypes were studied 402 using sequence-specific oligonucleotides primer methods. Recipients donor KIRs, HLA-C...
Anti-inflammatory cytokines have an important role in disease, tumour and transplant processes. Alterations the regulation of several been implicated a variety inflammatory disorders, including IBD (inflammatory bowel disease) [Crohn's disease (CD) ulcerative colitis (UC)]. Cytokine polymorphisms are also known to affect level gene expression. Thus, aim this study was determine relationship between cytokine pathologies Spanish population. Polymorphisms analysis performed using PCR-SSOP...
Background Alcoholic cirrhosis ( AC ) is a common cause of death among individuals abusing alcohol. In the last resort, liver transplantation LT considered only solution to save patient's life, generating socioeconomic and public health problems. Clinical sociodemographic characteristics, rejection frequency, short‐ long‐term graft survival are not well known in end‐term patients undergoing . The aim was determine clinical their incidence , main pre‐ posttransplant complications,...
Additive manufacturing is a vanguard technology that currently being used in several fields medicine. This study aims to evaluate the viability clinical practice of patient-specific 3D model helps improve strategies doctor-patient assistance. Data obtained from corneal topographer were make virtual by using CAD software, later print this FDM and get an exact replica each patient’s cornea consultation. Used printing software open-source, material was biodegradable its cost low. Clinic users...
Create a unique predictive model based on set of demographic, optical, and geometric variables with two objectives: classifying keratoconus (KC) in its first clinical manifestation stages establishing the probability having correctly classified each case.We selected 178 eyes subjects (115 males; 64.6%; 63 females, 35.4%). Of these, 74 were healthy control subjects, 104 suffered from KC according to RETICS grading system (61 early KC, 43 mild KC). Only one eye patient was selected, 27...
Open-angle glaucoma (OAG), the most prevalent clinical type of glaucoma, is still main cause irreversible blindness worldwide. OAG a neurodegenerative illness for which important risk factor elevated intraocular pressure (IOP). Many questions remain unanswered about OAG, such as whether nutritional or toxic habits, other personal characteristics, and/or systemic diseases influence course glaucoma. As such, in this study, we performed multicenter analytical, observational, case–control study...
Abstract Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers acute rejection (AR). The aim present multicenter study was to correlate percentage peripheral Treg in liver graft recipients drawn at baseline up 12 months after transplantation with presence AR. central memory (cm) (CD4 + CD25 high CD45RO CD62L ) monitored pre-transplant and 1 2 weeks, 1, 2, 3 6 year post-transplantation. same validation standard operating procedures were used all...
Missing self recognition makes cancer sensitive to natural killer cell (NKc) reactivity. However, this model disregards the NKc licensing effect, which highly increases reactivity through interactions of inhibitory immunoglobulin-like receptors (iKIR) with their cognate HLA-I ligands. The influence iKIR/HLA-ligand (HLA-C1/C2) on susceptibility and progression plasma (PC) dyscrasias was evaluated in 164 Caucasian patients 286 controls. Compared controls, myeloma accumulates KIR2DL1-L2+L3-...
This work pursues two objectives: defining a new concept of risk probability associated with suffering early-stage keratoconus, classifying disease severity according to the RETICS (Thematic Network for Co-Operative Research in Health) scale. It recruited 169 individuals, 62 healthy and 107 keratoconus diseased, grouped classification: 44 grade I; 18 II; 15 III; IV; V. Different demographic, optical, pachymetric eometrical parameters were measured. The collected data used training...
The validation of new methods for the diagnosis incipient cases Keratoconus (KC) with mild visual limitation is great interest in field ophthalmology. During asymmetric progression disease, current diagnostic indexes do not record geometric decompensation corneal curvature nor variation spatial profile that occurs singular points cornea. purpose this work to determine structural characterization asymmetry disease by using morpho-geometric parameters KC eyes including an analysis a...
Background: The harmful effect of alcohol on the immune system may be due to both a direct action or its metabolites cells as an indirect modifying different mechanisms intercellular interaction. interplay between stimulatory (aKIR) and inhibitory (iKIR) natural killer (NK) cell receptors their corresponding human leukocyte antigen (HLA) ligands influences outcome virus infection. aim was analyze influence KIR/HLA pair genetic profile in male alcoholic cirrhosis (AC) patients with without...
Chronic liver rejection (CR) represents a complex clinical situation because many patients do not respond to increased immunosuppression. Killer cell immunoglobulin-like receptors/Class I Human Leukocyte Antigens (KIR/HLA-I) interactions allow for predicting Natural (NK) alloreactivity and influence the acute of allograft. However, its meaning in CR graft remains controversial. KIR HLA genotypes were studied 513 transplants using sequence-specific oligonucleotides (PCR-SSO) methods. KIRs,...
The aim of this study was to analyze alcoholic cirrhosis in women who were undergo liver transplant, including their biochemical and clinical characteristics, main complications, survival rates, causes death compared with men cirrhosis.Our included 400 patients cirrhosis, which we divided according sex viral infections. Biochemical parameters the presence degree ascites encephalopathy, function status, rejection rates analyzed from 1 10 years cause at years.Patients nonviral transplant had...
Background. Clinical and molecular mechanisms involved in the cause time of death alcoholic cirrhosis (AC) patients undergoing liver transplantation (LT) are not entirely understood. In sudden cases, judicial autopsy practice is mandatory for determining circumstances death. The medico-legal data essential helping health authorities to guide future public activities, assess effectiveness systems, adopt necessary preventive measures improve adapt treatments order increase these patients’...
The Child-Pugh and model for end-stage liver disease (MELD) scores are widely used to predict the outcomes of transplant (LT). Both have similar prognostic values in most cases, although their benefits might differ some specific conditions. aim our study was analyze influence pre-transplant ascites encephalopathy post-transplant rejection development survival alcohol cirrhosis (AC) patients undergoing LT determine usefulness score assessment prognosis such patients.Two hundred eighty-one AC...