A5016949143- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Educational Technology in Learning
- Medication Adherence and Compliance
- Educational Innovations and Technology
- Health Literacy and Information Accessibility
- Forensic Entomology and Diptera Studies
- Pharmaceutical Practices and Patient Outcomes
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Forensic Anthropology and Bioarchaeology Studies
- Memory and Neural Mechanisms
- E-Learning and Knowledge Management
- Hepatitis C virus research
- Developmental Biology and Gene Regulation
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Organ Donation and Transplantation
Universidad de Murcia
2016-2025
Agència de Qualitat i Avaluació Sanitàries de Catalunya
2023
Biomedical Research Institute
2021
Instituto Murciano de Investigación Biosanitaria
2016-2018
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2018
National Legal Medicine Institute
2017
Hospital Universitario Virgen de la Arrixaca
2009-2016
Inserm
2014
Libertador Experimental Pedagogical University
2007
Abstract We studied the lateral and ventral pallial divisions of claustroamygdaloid complex by means analysis expression patterns developmental regulatory genes Tbr1 , Dbx1 Neurogenin 2 Emx1 Cadherin 8 Semaphorin 5A in mouse developing telencephalon, from embryonic day 12.5 until birth. Our results indicate that these help to distinguish distinct histogenetic telencephalon. is broadly expressed both (the lateroventral migratory stream plus mantle) during early intermediate development; its...
Abstract The amygdala controls emotional and social behavior regulates instinctive reflexes such as defense reproduction by way of descending projections to the hypothalamus brainstem. amygdalar are suggested show a cortico‐striato‐pallidal organization similar that basal ganglia (Swanson [2000] Brain Res 886:113–164). To test this model we investigated embryological origin molecular properties mouse centromedial extended subdivisions, which constitute major sources projections. We analyzed...
Abstract Dysfunctions in emotional control and social behavior are behind human neuropsychiatric disorders, some of which associated with an alteration amygdalar development. The medial extended amygdala is a key telencephalic center for behavior, but very little known about its We used vitro migration assays analyzing the origin neurons mouse embryos (E13.5–E16.5). compared immunofluorescence/immunohistochemistry calbindin radial glial fibers mRNA expression several genetic markers distinct...
Abstract We compared the combinatorial expression patterns of several LIM domain‐containing regulatory genes in ventrolateral pallium mouse and chicken, order to identify homologues ventral pallial amygdala other olfactory structures birds. Lmo3 , Lmo4 Lhx2 Lhx9 showed comparable telencephalon which allowed distinction and, particularly, entorhinal cortex. was expressed most both species, including, piriform cortex dorsal ventricular ridge (mesopallium, nidopallium, arcopallium) mouse,...
Background: Chronic wounds, such as diabetic ulcers, often fail to progress through healing due persistent inflammation, infections, and extracellular matrix (ECM) imbalances. Cathepsin D, an aspartate protease active in acidic environments, plays a pivotal role wound by mediating inflammatory responses, ECM remodeling, macrophage phenotype transitions. Its dysregulation, however, can impair healing, highlighting the need for targeted modulation of its activity. The aim this study was...
Abstract Background Aging implies a higher prevalence of chronic pathologies and corresponding increase in medication. The correct adherence use the medication are prerequisites for reducing risks disease progression, comorbidity, mortality. Medication literacy (ML) is specific ability to safely access understand information available concerning medication, act accordingly. Currently, there few instruments that ascertain extent ML general population. aim this work was analyse large cohort...
In Brief Background Killer immunoglobulin-like receptors (KIRs) bind human leukocyte antigen (HLA) class-I (HLA-I) ligands and regulate functions of natural killer cells subsets T cells. KIR/HLA-I interactions allow predicting cell alloreactivity in hematopoietic stem transplantation HLA-compatible kidney transplants, but its meaning liver remains controversial. Methods KIR HLA genotypes were studied 402 using sequence-specific oligonucleotides primer methods. Recipients donor KIRs, HLA-C...
Abstract Natural killer cell (NKc)-based therapies offer promising outcomes in patients with tumors, but they could improve appropriate selection of donors and optimization methods to expand NKcs vitro. Education through licensing interactions inhibitory immunoglobulin-like receptors (iKIR) NKG2A their cognate HLA class-I ligands optimizes NKc functional competence. This work has evaluated the role differentiation survival cancer patients. We have analyzed KIR KIR-ligand genes, expression...
Background Alcoholic cirrhosis ( AC ) is a common cause of death among individuals abusing alcohol. In the last resort, liver transplantation LT considered only solution to save patient's life, generating socioeconomic and public health problems. Clinical sociodemographic characteristics, rejection frequency, short‐ long‐term graft survival are not well known in end‐term patients undergoing . The aim was determine clinical their incidence , main pre‐ posttransplant complications,...
Hepatitis C virus (HCV) is enveloped RNA virus, encoding for a polyprotein that processed by cellular proteases. The responsible liver cirrhosis, allograft rejection, and human hepatocellular carcinoma. Based on studies including compositional analysis, odds ratio parity skew relative synonymous codon usage, bias, protein properties, it was evident usage bias in HCV dependent upon the nucleotide composition. Codon context analysis revealed CTC-CTG as preferred pair. While CGA CGT codons were...
We analyzed the development of immunoreactive expression patterns for neurotransmitter gamma-aminobutyric acid (GABA) and calcium-binding proteins calbindin, calretinin, parvalbumin in embryonic postnatal mouse claustral complex. Each protein shows a different temporal spatial pattern development. Calbindin-positive cells start to be seen very early during embryogenesis increase dramatically until birth, thus becoming most abundant cell type development, especially ventral pallial part...
Abstract We studied the development of neurons and fibers containing calbindin, calretinin, parvalbumin in mouse pallial amygdala, with special emphasis on those basolateral amygdalar complex. Numerous calbindin‐immunoreactive (CB+) cells were observed incipient complex cortical area from E13.5. At E16.5, CB+ became more abundant lateral nuclei than basomedial nucleus, showing a pattern very similar to that γ‐aminobutyric acid (GABA)ergic neurons. Many amygdala appeared originate anterior...
Abstract Ascertaining the vital origin of skin wounds is one most challenging problems in forensic pathology. The literature describes biomarkers and methods for differentiating postmortem wounds, although no clear conclusions have been reached. aim this study was to characterize human by analyzing concentrations metallic ions expression P-selectin cathepsin D ligature marks a cohort suicidal hangings which vitality previously demonstrated. A total 71 were analyzed within interval 19 36...
The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. aim this study was to analyze the presence DSAs a large cohort 810 recipients undergoing transplant determine influence on acute (AR) or chronic rejection (CR), graft loss allograft survival. were identified using complement dependent cytotoxicity crossmatch (CDC-CM) multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that...