A5016014851- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Neurology and Historical Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- MicroRNA in disease regulation
- Neuroscience, Education and Cognitive Function
- Immune cells in cancer
- History of Medicine Studies
- Multiple Sclerosis Research Studies
- Neurobiology and Insect Physiology Research
- Spanish Philosophy and Literature
- Organ Donation and Transplantation
- Fibroblast Growth Factor Research
- History of Education in Spain
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Biochemical Analysis and Sensing Techniques
- Photochromic and Fluorescence Chemistry
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- Neuroscience and Neuropharmacology Research
- Renal and Vascular Pathologies
Instituto Cajal
2016-2025
Consejo Superior de Investigaciones Científicas
2007-2024
Hospital Nacional de Parapléjicos
2012-2023
Universidad Complutense de Madrid
2023
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2003-2023
Universidad Pablo de Olavide
2023
National University of San Marcos
2022
Rafael Advanced Defense Systems (Israel)
2022
Goethe Institute
2022
National Academies of Sciences, Engineering, and Medicine
2021
The word “glia” was coined in the mid‐19th century and defined as “the nerve glue”. For decades, it assumed to be a uniform matrix, until cell theorists raised “neuron doctrine” which stipulated that nervous tissue composed of individual cells. term “astrocytes” introduced late 19th synonym for glial cells, but Santiago Ramón y Cajal who “third element” distinct from cells (astrocytes) neurons. It not 1919 when Pío del Río‐Hortega, an alumnus School, modern terms we use today, thoroughly...
Oligodendrocytes, the myelin-forming cells of CNS, are generated from multiple foci distributed along developing neural tube. Little is known about endogenous guidance cues controlling migration oligodendrocyte precursor (OPCs) their site emergence toward final destination, mainly future white matter tracts. During embryonic development, optic nerve populated by OPCs originating in diencephalon that migrate chiasm retina. Here we show migrating into express semaphorin receptors neuropilin-1...
Abstract We studied the lateral and ventral pallial divisions of claustroamygdaloid complex by means analysis expression patterns developmental regulatory genes Tbr1 , Dbx1 Neurogenin 2 Emx1 Cadherin 8 Semaphorin 5A in mouse developing telencephalon, from embryonic day 12.5 until birth. Our results indicate that these help to distinguish distinct histogenetic telencephalon. is broadly expressed both (the lateroventral migratory stream plus mantle) during early intermediate development; its...
ABSTRACT Netrin 1 is a long-range diffusible factor that exerts chemoattractive or chemorepulsive effects on developing axons growing to away from the neural midline. Here we used tissue explants study action of netrin in migration several cerebellar and precerebellar cell progenitors. We show strong effect migrating neurons embryonic lower rhombic lip at E12-E14, which give rise nuclei. promotes exit postmitotic upregulates expression TAG-1 these neurons. In addition, presence 1, are not...
ABSTRACT The semaphorins are the largest family of repulsive axon guidance molecules. Secreted bind neuropilin receptors and repel sensory, sympathetic motor axons. Here we show that CA1, CA3 dentate gyrus axons from E15-E17 mouse embryo explants selectively repelled by entorhinal cortex neocortex. secreted Sema III IV their Neuropilin-1 -2 expressed in hippocampal formation during appropriate stages. strongly axons; only III. An antibody against blocks action cortex, but has no effect on...
Multiple sclerosis is a demyelinating disease that affects ∼2,000,000 people worldwide. In the advanced stages of disease, endogenous oligodendrocyte precursors cannot colonize lesions or differentiate into myelinating oligodendrocytes. During development, both FGF-2 and Anosmin-1 participate in precursor cell migration, acting via FGF receptor 1 (FGFR1). Hence, we performed histopathological molecular analysis these developmental modulators postmortem tissue blocks from multiple patients....
Abstract Multiple Sclerosis (MS) is a demyelinating/inflammatory disease of the central nervous system. Relapsing‐remitting MS characterized by relapsing phase with clinical symptoms and production inflammatory cell infiltrates, period remission during which patients recover partially. Myeloid‐derived suppressor cells (MDSCs) are immature capable suppressing response through Arginase‐I (Arg‐I) activity, among other mechanisms. Here, we have identified Arg‐I + ‐MDSCs in spinal cord...
During development, growth cones can be guided at a distance by diffusible factors, which are attractants and/or repellents. The semaphorins the largest family of repulsive axon guidance molecules. Secreted bind neuropilin receptors and repel sensory, sympathetic, motor, forebrain axons. We found that in rat embryos, olfactory epithelium releases factor repels bulb In addition, Sema A IV, but not III, E, or H, able to orient vitro axons; IV has strong action, whereas appears attract those...
COVID-19 is an ongoing viral pandemic that emerged from East Asia and quickly spread to the rest of world. SARS-CoV-2 virus causing COVID-19. Acute respiratory distress syndrome (ARDS) definitely one main clinically relevant consequences in patients with Starting earliest reports pandemic, two peculiar neurological manifestations (namely, hyposmia/anosmia dysgeusia) were reported a proportion infected by SARS-CoV-2. At present, physiopathologic mechanisms accounting for onset these symptoms...
(1951). Rapport N° 1 Aspects Anatomiques de la Transmission Synaptique Ganglionnaire chez les Mammiferes. Archives Internationales Physiologie: Vol. 59, No. 4, pp. 479-513.
ApTOLL is an aptamer selected to antagonize toll-like receptor 4 (TLR4), a relevant actor for innate immunity involved in inflammatory responses multiple sclerosis (MS) and other diseases. The currently available therapeutic arsenal treat MS composed of immunomodulators but, date, there are no (re)myelinating drugs clinics. In our present study, we studied the effect on different animal models MS.
Myelination is the terminal step in a complex and precisely timed program that orchestrates proliferation, migration differentiation of oligodendroglial cells. It thought Sonic Hedgehog (Shh) acting on Smoothened (Smo) participates regulating this process, but these effects are highly context dependent. Here, we investigate development remyelination from three specific transgenic lines: NG2-Cre
Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show PC widely expressed neurons during development. interacts with ERM family, NHERF1/2 RhoA/G. Experiments vitro phenotypic analyses podxl-deficient mice indicate involved neurite growth, branching axonal fasciculation,...
Within the central nervous system, olfactory system fascinates by its developmental and physiological particularities, is one of most studied models to understand mechanisms underlying guidance growing axons their appropriate targets. A constellation contact-mediated (laminins, CAMs, ephrins, etc.) secreted (semaphorins, slits, growth factors, are known play different roles in establishment synaptic interactions between epithelium, bulb (OB) cortex. Specific this (including amazing family...
Abstract The innate immune response is mediated by primary modulators such as cytokines and chemokines that together with cells resident glia orchestrate CNS immunity inflammation. Growing evidence supports the endocannabinoid 2‐arachidonoylglycerol (2‐AG) exerts protective actions in injury models. Here, we used acute phase of Theiler's virus induced demyelination disease (TMEV‐IDD) a model neuroinflammation to investigate whether 2‐AG modifies brain responses TMEV leukocyte trafficking. or...
Multiple Sclerosis (MS) is the second cause of paraplegia among young adults, after all types CNS traumatic lesions. In its most frequent relapsing-remitting form, severity disease course very heterogeneous, and reliable evaluation remains a key issue for clinicians. Myeloid-Derived sSuppressor Cells (MDSCs) are immature myeloid cells that suppress inflammatory response, phenomenon related to resolution or recovery clinical symptoms associated with experimental autoimmune encephalomyelitis...
Abstract The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis started near plaques in both AD mouse models and samples. However, endothelial cells express molecular signature of non-productive (NPA) accumulate, plaques, a tip cell marker IB4 reactive vascular anomalies with NOTCH activity. Notably, NPA induction by loss presenilin, whose mutations cause...
Multiple sclerosis (MS) is a chronic neurological disease that currently lacks effective curative treatments. There need to find therapies, especially reverse the progressive demyelination and neuronal damage. Oligodendrocytes form myelin sheath around axons in central nervous system (CNS) oligodendrocyte precursor cells (OPCs) undergo mechanisms enable spontaneously partial repair of damaged lesions. The aim this study was discover small molecules with potential effects demyelinating...