A5007744700- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Infectious Encephalopathies and Encephalitis
- Barrier Structure and Function Studies
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Coronary Interventions and Diagnostics
Instituto de Biomedicina de Sevilla
2019-2024
Universidad de Sevilla
2019-2024
Hospital Universitario Virgen del Rocío
2021-2024
University Hospital Bonn
2023
University of Bonn
2023
Heidelberg University
2023
University Hospital Heidelberg
2023
Abstract The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis started near plaques in both AD mouse models and samples. However, endothelial cells express molecular signature of non-productive (NPA) accumulate, plaques, a tip cell marker IB4 reactive vascular anomalies with NOTCH activity. Notably, NPA induction by loss presenilin, whose mutations cause...
Microglial cells are key contributors to Alzheimer’s disease (AD), constituting the first cellular line against Aß plaques. Local hypoxia and hypoperfusion, which typically present in peripheral inflammatory foci, also common AD brain. We describe here that deposits hypoxic hypoperfused plaque-associated microglia (AßAM) characterized by expression of hypoxia-inducible factor 1 (HIF1)-regulated genes. Notably, AßAM simultaneously upregulate genes involved anaerobic glycolysis oxidative...
Abstract The protective efficacy of vaccines against SARS-CoV-2 infection in the brain is yet unclear. Here, susceptible transgenic K18-hACE2 mouse model severe COVID-19 disease, we report a detailed spatiotemporal description and replication different areas brain. Remarkably, occurs primarily neurons, producing important neuropathological alterations such as neuronal loss, incipient signs neuroinflammation, vascular damage infected mice. Notably, one or two doses modified vaccinia virus...