A5064548227- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- SARS-CoV-2 and COVID-19 Research
- Infectious Encephalopathies and Encephalitis
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
Universidad de Sevilla
2018-2023
Hospital Universitario Virgen del Rocío
2018-2023
Instituto de Biomedicina de Sevilla
2018-2023
Abstract Background The use of long‐term immunosuppressive treatments on neural transplantation has been controversial during the last decades. Although nowadays there is a consensus about necessity maintaining permanent state immunosuppression to preserve survival cerebral grafts, little known effects that chronic produces both neurodegenerative process and transplants function. Methods Here, we establish new protocol, based discontinuous administration CsA (15 mg/kg; s.c.) prednisone (20...
The development and survival of dopaminergic neurons are influenced by the fibroblast growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a major regulator this signaling pathway, controlling FGF diffusion, receptor interaction shuttling. In particular, previous work showed A1 overexpression results in more olfactory bulb. Prompted those intriguing results, study, we investigated effects on different populations catecholaminergic central (CNS)...
Abstract The protective efficacy of vaccines against SARS-CoV-2 infection in the brain is yet unclear. Here, susceptible transgenic K18-hACE2 mouse model severe COVID-19 disease, we report a detailed spatiotemporal description and replication different areas brain. Remarkably, occurs primarily neurons, producing important neuropathological alterations such as neuronal loss, incipient signs neuroinflammation, vascular damage infected mice. Notably, one or two doses modified vaccinia virus...
Abstract The development and survival of dopaminergic neurons are influenced by the fibroblast growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a major regulator this signaling pathway, controlling FGF diffusion, receptor interaction shuttling. Furthermore, overexpression A1 in vivo gives rise to higher number olfactory bulb. Here, using overexpressing mice (A1-mice), we studied effects on different populations catecholaminergic central (CNS)...