A5049707703- Childhood Cancer Survivors' Quality of Life
- COVID-19 and healthcare impacts
- Neutropenia and Cancer Infections
- Cardiac Ischemia and Reperfusion
- Educational theories and practices
- Spanish Linguistics and Language Studies
- Linguistics and Discourse Analysis
- Sepsis Diagnosis and Treatment
- Literacy and Educational Practices
- Literary and Cultural Studies
- Acute Lymphoblastic Leukemia research
- COVID-19 and Mental Health
- Health and Medical Education
- Public Health and Environmental Issues
- Urinary Tract Infections Management
- Glioma Diagnosis and Treatment
- Language, Metaphor, and Cognition
- Economic and Social Development
- Public Policy and Governance
- E-Learning and Knowledge Management
- Pediatric Pain Management Techniques
- Advances in Oncology and Radiotherapy
- Global Health and Surgery
- Adolescent and Pediatric Healthcare
- Parkinson's Disease and Spinal Disorders
St. Jude Children's Research Hospital
2021-2024
Universidad Autónoma de Guadalajara
2024
The Spine Institute
2024
Tecnológico de Monterrey
2014-2018
Fundación Universitaria Sanitas
2018
Universidad de Oriente
2006
Stress-induced cardiomyopathy, triggered by acute catecholamine discharge, is a syndrome characterized transient, apical ballooning linked to heart failure and ventricular arrhythmias. Rats receiving an isoproterenol (ISO) overdose (OV) suffer cardiac apex ischemia-reperfusion damage arrhythmia, then undergo remodeling dysfunction. Nevertheless, the subcellular mechanisms underlying dysfunction after subsides are not thoroughly understood. To address this question, Wistar rats received...
Despite the importance of mitochondrial Ca(2+) to metabolic regulation and cell physiology, little is known about mechanisms that regulate entry into mitochondria. Accordingly, we established a system determine role uniporter in an isolated heart model, at baseline during increased workload following β-adrenoceptor stimulation.Cardiac contractility, oxygen consumption intracellular transients were measured ex vivo perfused murine hearts. Ru360 spermine used modify activity. Changes content...
Paediatric Early Warning Systems (PEWSs) improve identification of deterioration, however, their sustainability has not been studied. Sustainability is critical to maximise impact interventions like PEWS, particularly in low-resource settings. This study establishes the reliability and validity a Spanish-language Clinical Assessment Tool (CSAT) assess clinical capacity sustain resource-limited hospitals.Participants included PEWS implementation leadership teams 29 paediatric cancer centres...
In the face of unprecedented challenges because coronavirus disease 2019, interdisciplinary pediatric oncology teams have developed strategies to continue providing high-quality cancer care. This study explored factors contributing health care resilience as perceived by childhood providers in all resource level settings. qualitative consisted 19 focus groups conducted 16 countries 8 languages. Seven been previously defined important for resilient including: 1) situ practical experience, 2)...
Casiopeinas are a group of copper-based antineoplastic molecules designed as less toxic and more therapeutic alternative to cisplatin or Doxorubicin; however, there is scarce evidence about their effects on the whole heart cardiomyocytes. Given this, rat hearts were perfused with Doxorubicin mechanical performance, energetics, mitochondrial function measured. As well, Casiopeinas-triggered cell death explored in isolated III-Ea, II-gly, III-ia induced progressive sustained inhibition...
Background and aims Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- middle-income countries are lower due to deficiencies multilevel factors, including access timely diagnosis, risk-stratified therapy, comprehensive supportive care. This retrospective study aimed analyze outcomes for pediatric ALL at 16 centers Mexico. Methods Patients <18 years of age with newly diagnosed B- T-cell treated between January 2011 December 2019 were included. Clinical biological...
Historically, qualitative research has complemented quantitative biologic and epidemiologic studies to provide a more complete understanding of pandemics. The COVID-19 pandemic generated unique novel challenges for researchers, who have embraced creative solutions including virtual focus groups rapid analyses continue their work. We present our experience conducting multilingual global study healthcare resilience among teams pediatric oncology professionals during the pandemic. an in-depth...
A 75-year-old male with a history of medically controlled arterial hypertension (AH) and Parkinson disease (PD), reporting degenerative lumbar scoliosis stenosis.Underwent for coronal deformity correction stenosis decompression.An immediate successful radiological clinical outcome, but six weeks after surgical intervention, patient thoracic pain, X-rays showed fracture the upper instrumented vertebra.Due to multimorbidity we decided conservative treatment, expecting...
Abstract BACKGROUND AND AIMS Reports from low-and middle-income countries (LMICs) indicate lower survival in medulloblastoma (MB), though these studies are mainly single institutions. This multi-institutional, retrospective study aimed to analyze the outcomes for MB 9 centers 8 LMICs. METHODS Patients <18 years old with newly diagnosed MB, treated January 2014 December 2018 Egypt, El Salvador, Malaysia, Mexico, Pakistan, Peru, Philippines, and Uruguay were included. Data on...
Abstract Background Bacteremia is a common infectious complication among pediatric oncology patients, yet management practices are not standardized. Antibiotic treatment courses as short seven days supported by literature and could improve patient quality of life resource use. However, it known if associated with greater failure in immunocompromised patients. Methods We conducted retrospective study at St. Jude Children’s Research Hospital, including patients laboratory confirmed bloodstream...
Introducción. El tratamiento oncológico adicional a la cirugía en los pacientes con cáncer gástrico, sigue siendo un tema de debate. Se compararon el pronóstico y las complicaciones quimioterapia perioperatoria adyuvante, para identificar mejor esquema tratamiento.Materiales métodos. llevó cabo estudio longitudinal, retrospectivo cohorte histórica, que incluía todos recibieron alguno dos esquemas tratamiento. Los principales objetivos fueron evaluar supervivencia perioperatorias...
Abstract Background The COVID‐19 pandemic altered healthcare systems globally, causing delays in care delivery and increased anxiety among patients families. This study examined how hospital stakeholders clinicians perceived the global impact of on children with cancer their Methods secondary analysis data from a qualitative consisting 19 focus groups conducted 8 languages throughout 16 countries. A codebook was developed novel codes derived inductively transcript review. In‐depth focused...
Buscamos interpretar la noción de desarrollo educativo en el liceo venezolano dos documentos oficiales del gobierno inicial Chávez, a fin develar su trasfondo ideológico. Para ello, revisamos información sobre las bases ideológicas y principios educativos ONU UNESCO para ese momento, con intención determinar orientación que seguían (Guillén, 2007; ONU, 2000 UNESCO, 2000): orientaciones socialistas o derivadas por consenso entre naciones región. Desde punto vista teórico, nos orientamos...
Infections in Sursery, the Intensive Care Unit, inc[udin8 Patients with Burns $75In cumutative dose 60g of IVIG number ptatetets increased to 30G/L and breeding disappeared.We decided finish treatment increasing 50 G/L. Conclusion:The use intravenous immunogtobutins immunosuppressive doses is indicated patients thrombocytopenia associated ptatetet autoantibodies resistant conventionat treatment.Severat mechanisms action have been suggested for therapeutic IVIG.
Abstract Background The care of children with cancer requires systematic and standardized management to avoid complications associated treatment, one which is infection. Fever an important sign infection in a neutropenic patient early unfavorable outcomes. Many factors contribute delays recommended steps fever management. objective this project was measure the delay times key identify challenges opportunities improve process. Methods A prospective quality improvement initiated between June...