A5009516872- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Pulmonary Hypertension Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Cardiac Ischemia and Reperfusion
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Metal complexes synthesis and properties
- Diet, Metabolism, and Disease
- GABA and Rice Research
- Biochemical effects in animals
- Graphene and Nanomaterials Applications
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Carbon Nanotubes in Composites
- Cannabis and Cannabinoid Research
- CAR-T cell therapy research
- Molecular Biology Techniques and Applications
- Bacterial biofilms and quorum sensing
- Metabolism and Genetic Disorders
- Orthopedic Infections and Treatments
- Diet and metabolism studies
- Fuel Cells and Related Materials
- Muscle Physiology and Disorders
Tecnológico de Monterrey
2017-2024
University of Minnesota Medical Center
2023
Centro de Investigación en Materiales Avanzados
2016
Instituto Politécnico Nacional
2016
Cyclophilin D (CypD) mediates the mitochondrial permeability transition pore (mPTP) opening that contributes to dysfunction. CypD is regulated by its acetylation/deacetylation state depends on Sirtuin-3 (SIRT3) deacetylase. Since obesity and metabolic syndrome decrease SIRT3 activity expression, we tested hypothesis hyperacetylation promotes dysfunction under this pathophysiological state, which associated with ventricular heart failure.Myocardial tissue samples from patients left failure,...
Abstract Bacterial species are able to colonize and establish communities in biotic abiotic surfaces. Moreover, within the past five decades, incidence of bacterial strains resistant currently used antibiotics has increased dramatically. This led diverse health issues economical losses for different industries. Therefore, there is a latent need develop new more efficient antimicrobials. work reports an production exopolysaccharide native yeast strain isolated from Mexican Northeast,...
Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related abnormal calcium handling and energetic failure cardiomyocytes. Moreover, precise mechanisms underlying this debacle remain unclear. In order elucidate these mechanisms, article explores ex vivo function mitochondria after exposure nanoSiO2.The cumulative...
Intracellular Ca2+ mishandling is an underlying mechanism in hypoxia/reoxygenation (H/R) injury that results mitochondrial dysfunction and cardiomyocytes death. These events are mediated by (mCa2+) overload facilitated the calcium uniporter (MCU) channel. Along this line, we evaluated effect of siRNA-targeting MCU subjected to H/R injury. First, treated with siRNA demonstrated a reduction expression 67%, which resulted significant decrease transport. showed decreased permeability pore...
Pulmonary arterial hypertension (PAH) is a life-threatening disease that characterized by an increase in pulmonary vascular pressure, leading to ventricular failure and high morbidity mortality. Resveratrol, phenolic compound sirtuin 1 pathway activator, has known dietary benefits used as treatment for anti-inflammatory cardiovascular diseases. Its therapeutic effects have been published the scientific literature; however, its PAH are yet be precisely elucidated. Using murine model of...
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vessel remodeling; however, its severity and impact on survival depend right ventricular (RV) failure. Resveratrol (RES), a polyphenol found in red wine, exhibits cardioprotective effects RV dysfunction PAH. However, most literature has focused RES protective effect lung vasculature; recent finding indicates that independent of pressure dysfunction, although the underlying mechanism not been determined. Therefore, this study...
Background: Thyroid hormone status in hypothyroidism (HT) downregulates key elements Ca2+ handling within the heart, reducing contractility, impairing basal energetic balance, and increasing risk of cardiovascular disease. Mitochondrial transport is reduced HT, tolerance to reperfusion damage has been documented, but precise mechanism not well understood. Therefore, we aimed determine stoichiometry activity mitochondrial uniporter or uniplex an HT model relevance opening permeability...
Casiopeinas are a group of copper-based antineoplastic molecules designed as less toxic and more therapeutic alternative to cisplatin or Doxorubicin; however, there is scarce evidence about their effects on the whole heart cardiomyocytes. Given this, rat hearts were perfused with Doxorubicin mechanical performance, energetics, mitochondrial function measured. As well, Casiopeinas-triggered cell death explored in isolated III-Ea, II-gly, III-ia induced progressive sustained inhibition...
Dystrophic hearts have poor contractile reserve that is associated with a reduction in myocardial energetics. We demonstrate oxygen delivery does not contribute to the limited energy production of dystrophic heart even increased workloads. Cytochrome optical spectroscopy contracting reveals alterations complex IV and evidence depolarized mitochondrial membranes. show specific electron transport chain may
Disulfiram (DSF) reduces insulin resistance and weight gain in obese mice. However, the effect on adipose tissue is unexplored due to their high instability under physiological conditions, limiting clinical applications. Thus, it meaningful develop a DSF carrier for sustained release tissue. We optimized synthesis of poly-ε-caprolactone (PCL) nanoparticles (NPs) loaded with analyzed cells vitro.
During recent years the role of immune system in progression heart failure (HF) has become an area interest to better understand physiopathological mechanisms its progression. Some immunomodulators have been tested for efficacy reducing inflammatory mediators patients with HF. However, one greatest limitations encountered when trying bring those treatments is side effect these drugs. Keeping this mind, nanotechnology advancing rapidly during past few years. Nanoparticles can carry...
Heart failure (HF), a cardiovascular (CV) end-stage clinical syndrome, is known to progress as continuum of maladaptive changes with an underlying pro-inflammatory state. With increasing prevalence and high 5-year mortality rate despite optimal treatment, HF demands novel therapies. In this pursuit, strategies for the modulation adaptive immunity show promising results, among them use methotrexate (MTX). While anti-inflammatory effects MTX are partially understood, mechanisms that explain...