A5042972139- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Peroxisome Proliferator-Activated Receptors
- ATP Synthase and ATPases Research
- Cardiac Ischemia and Reperfusion
- Non-Invasive Vital Sign Monitoring
- Diabetes Management and Research
- Transcranial Magnetic Stimulation Studies
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Neuroscience and Neural Engineering
- Diet and metabolism studies
- Optical Imaging and Spectroscopy Techniques
- GABA and Rice Research
- Neuroendocrine regulation and behavior
- Spinal Cord Injury Research
- Cardiovascular and exercise physiology
Hospital Zambrano Hellion
2024-2025
Tecnológico de Monterrey
2020-2025
Benemérita Universidad Autónoma de Puebla
2017-2020
Hospital de Sant Pau
2017
The role of the mitochondrial calcium uniporter (MCU) in energy dysfunction and hypertrophy heart failure (HF) remains unknown. In angiotensin II (ANGII)–induced hypertrophic cardiac cells we have shown that overexpress MCU present bioenergetic dysfunction. However, by silencing MCU, cell are prevented blocking overload, increase reactive oxygen species, activation nuclear factor kappa B–dependent proinflammatory signaling. Moreover, identified a calcium/calmodulin–independent protein kinase...
Heart failure (HF) is a heterogeneous condition that can be categorized according to the left ventricular ejection fraction (EF) into HF with reduced (HFrEF) or preserved (HFpEF) EF. Although HFrEF and HFpEF share some common clinical manifestations, mechanisms underlying each phenotype are often found distinct. Identifying shared divergent pathophysiological features might expand our insights on pathophysiology assist search for therapies subtype. In this study, we evaluated contrasted two...
Macrophages chronically exposed to saturated fatty acids, such as those encountered in adipose tissue, present a pro-inflammatory phenotype with characteristic foamy morphology. This feature is caused by the excess uptake of circulating lipids, yielding large cytoplasmic lipid bodies formed triacylglycerols and cholesteryl derivatives. Palmitic acid (PA) potent inflammatory inducer macrophages after chronic exposure this acid. However, acute unable activate phenotype, although it sufficient...
Stochastic resonance (SR) is an inherent and counter-intuitive mechanism of signal-to-noise ratio (SNR) facilitation in biological systems associated with the application intermediate level noise. As a first step to investigate detail this phenomenon somatosensory system, here we examined whether direct noisy light on pyramidal neurons from mouse-barrel cortex expressing light-gated channel channelrhodopsin-2 (ChR2) can produce evoked field potentials. Using anesthetized Thy1-ChR2-YFP...
Spinal motoneurons exhibit sustained afterdischarges and plateau potentials following a brief high-frequency stimulation of Ia afferents. Also, there is evidence that spinal cord interneurons potentials. However, to our knowledge, are not reports about the possible afterdischarge behavior lumbar activated by Given receiving monosynaptic inputs from afferents, then these cells could be in parallel motoneurones after repetitive muscle stretch. We explored this possibility cats with...
Abstract There is evidence that a variety of central and afferent stimuli, including swallowing, can produce phase resetting in the respiratory rhythmicity. Also, there are reports about intrinsic linkage between locomotion respiration. However, little known interaction pattern generators (CPGs) for scratching The present study aims to examine whether activation CPG produces rhythm. We employed decerebrate cats apply brief tactile stimuli pinna during inspiratory-expiratory transition....
The hemodynamic response is a neurovascular and metabolic process in which there rapid delivery of blood flow to neuronal tissue activation. functional magnetic resonance imaging (fMRI) the near-infrared spectroscopy (fNIRS), for instance, are based on physiological principles such responses. Both techniques allow mapping active regions events occurring. However, although both have revolutionized neurosciences, they mostly employed neuroimaging human brain but not spinal cord during tasks....
Heart failure with reduced ejection fraction (HFrEF) is accompanied by disregulation of cardiovascular function. rate variability (HRV) commonly used to assess autonomic dysfunction in HFrEF. However, analysis stroke volume (SVV) may provide additional insights. We examined HRV and SVV a mouse model HFrEF mice exhibited versus controls, confirming cardiac contractile dysfunction. was preserved mice. markedly diminished, indicating dissociation between regulation. Using mathematical model, we...